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1

Immunology of viral co-infections with HIV

100%
Northfield J. W., Harcourt G., Lucas M., Klenerman P.
Archivum Immunologiae et Therapiae Experimentalis
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2005
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tom 53
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nr 1
2

Hepatitis C - new developments in the studies of the viral life cycle

84%
Rychlowska M., Bienkowska-Szewczyk K.
Acta Biochimica Polonica
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2007
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tom 54
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nr 4
703-715
Hepatitis C virus (HCV) is a causative agent of chronic liver disease leading tocirrhosis, liver failure and hepatocellular carcinoma. The prevalence of HCV is estimated as 3% of the world population and the virus is a major public health problem all over the world. For over 16 years, since HCV had been discovered, studies of the mechanisms of the viral life cycle and virus-host interactions have been hampered by the lack of a cell culture system allowing the virus to be grown in laboratory conditions. However, in recent years some new model systems to study HCV have been developed. The major breakthrough of the last two years was the cell culture system for maintaining the virus in an adapted hepatocyte-derived cell line. This review describes the techniques and applications of most of the in vitrosystems and animal models currently used for working with hepatitis C virus
3
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Markers of infectious hepatitis A, B, C in biopreparations

84%
Bucholc B., Kalinowska B.
Bulletin of the Veterinary Institute in Puławy
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1998
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tom 42
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nr 1
4

Does hepatitis B virus or hepatitis C virus infection influence CD4 count in HIV-positive individuals?

84%
Smiatacz T., Zielinska W.
Archivum Immunologiae et Therapiae Experimentalis
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1996
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tom 44
|
nr 5-6
5

Hepatotropic viruses seen by clinicians

84%
Zielinska W., Smiatacz T.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
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tom 44
|
nr 5-6
6

ATP-binding domain of NTPase-helicase as a target for hepatitis C antiviral therapy

84%
Borowski P., Mueller O., Niebuhr A., Kalitzky M., Hwang L. H., Schmitz H., Siwecka M. A., Kulikowski T.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 1
To enhance the inhibitory potential of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) vs hepatitis C virus (HCV) NTPase/helicase, ribavirin-5'-triphosphate (ribavirin-TP) was synthesized and investigated. Ribavirin-TP was prepared with the use of modified Yoshikawa-Ludwig-Mishra-Broom procedure (cf. Mishra & Broom, 1991, J. Chem. Soc., Chem. Commun, 1276-1277) involving phosphorylation of unprotected nucleoside. Kinetic analysis revealed enhanced inhibitory potential of ribavirin-TP (IC50=40 µM) as compared to ribavirin (IC50 > 500 µM). Analysis of the inhibition type by means of graphical methods showed a competitive type of inhibition with respect to ATP. In view of the relatively low specificity towards nucleoside-5'-triphosphates (NTP) of the viral NTPase/helicases, it could not be ruled out that the investigated enzyme hydrolyzed the ribavirin-TP to less potent products. Investigations on non- hydrolysable analogs of ribavirin-TP or ribavirin-5'-diphosphate (ribavirin-DP) are currently under way.
7

Comparison of the long-term effects of treatment with oral and parenteral interferon alpha in chronic viral hepatitis patients

67%
Zielinska W., Korczak-Rogon A., Paszkiewicz J., Kowalik M., Cummins J. M., Georgiades J. A.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
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tom 44
|
nr 5-6
8

Assessment of food consumption pattern of patients suffering from chronic hepatitis C virus

67%
El-Shobaki F. A., El-Banna N. H., Mokhtar H. M., Mahmoud M. H., Farag M. H.
Polish Journal of Food and Nutrition Sciences
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2001
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tom 10
|
nr 3
Nutritional status of patients infected with hepatitis was studied. Twenty four male patients suffering from chronic hepatitis C virus infection were selected from those attending the outpatients clinic in El-Harm Hospital. Also 21 male healthy volunteers were taken as controls. Clinical and dietary status of all individuals was examined. There were 4 cases with cirrhosis associated with ascites, 8 cases with splenomegaly, 2 cases had liver cirrhosis and one case had hematuria. Significantly higher values for the activity of AST, ALT and bilirubin were reported for patients suffering from chronic hepatitis. Patients consumed significantly less calories, proteins and fats compared to controls. Patients also consumed less fiber but the differences were not significant. The intake of phosphorus, zinc and magnesium of hepatitis patients was significantly lower than that of controls. No significant change in the intake of iron, potassium or calcium was reported. Significant drop in the intake of vitamins B1, B2, niacin, B6, B12, folate and vitamin E was reported for patients suffering from hepatitis. Intake of essential amino acids of hepatitis patients was significantly lower as compared with controls. The present study indicates that those patients need special dietary management. Improvement of patients appetites to increase their food intake from carbohydrates and protein but not fat must be considered. Also, the diets must be supplemented with calcium, phosphorus and B-vitamins but not iron. Reducing the intake of iron is essential to prevent iron overdose with its clinical complications. Those patients need special programme of nutrition education to help them to select the most beneficial food they need to escape the complication of the disease.
9

Treatment of six patients with chronic active HCV hepatitis, with low dose natural human interferon alpha administered orally

67%
Zielinska W., Paszkiewicz J., Korczak A., Wlasiuk M., Zoltowska A., Szutowicz A., Cummins J. M., Georgiades J. A.
Archivum Immunologiae et Therapiae Experimentalis
|
1993
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tom 41
|
nr 3-4
10

Hepatitis C virus [HCV] serotype in the asymptomatic HCV-infected patients from selected groups

67%
Pawlowska M., Halota W., Bulik F., Topczewska-Staubach E.
Archivum Immunologiae et Therapiae Experimentalis
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1997
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tom 45
|
nr 5-6
11

The incidence and significance of pattern-recognition receptors in chronic viral hepatitis types B and C in man

59%
Mozer-Lisewska I., Sikora J., Kowala-Piaskowska A., Kaczmarek M., Dworacki G., Zeromski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
|
tom 58
|
nr 4
295-302
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