Wyniki wyszukiwania

1

The pinocytosis in amoeba proteus induced by subthreshold concentration of heparin

100%

Grebecka L., Klopocka W.

Postępy Biologii Komórki

|

1989

|

tom 16

|

nr 1

2

Heparin enhances generation of natural killer activity in vitro

100%

Wasik M., Gorski A.

Archivum Immunologiae et Therapiae Experimentalis

|

1994

|

tom 42

|

nr 1

3

Phosphorylation of yeast ribosomal proteins by CKI and CHII in the presence of heparin

100%

Wojda I., Cytrynska M., Frajnt M., Jakubowicz T.

Cellular and Molecular Biology Letters

|

1998

|

tom 03

|

nr 3

4

Protective and therapeutic effect of heparin in acute pancreatitis

86%

Ceranowicz P., Dembinski A., Warzecha Z., Dembinski M., Cieszkowski J., Rembiasz K., Konturek S. J., Kusnierz-Cabala B., Tomaszewska R., Pawlik W. W.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 4

103-125

5

Pharmacogenetic considerations of anticoagulant medication

86%

Miklosz J., Kalaska B., Mogielnicki A.

Journal of Physiology and Pharmacology

|

2018

|

tom 69

|

nr 4

6

Effect of heparin on the course of sulphur dioxide induced bronchitis in rats

86%

Krasnowska M., Kwasniewski A., Rabczynski J., Fal A., Kuryszko J.

Archivum Immunologiae et Therapiae Experimentalis

|

1998

|

tom 46

|

nr 1

7

Functions of human complement inhibitor C4b-binding protein in relation to its structure

86%

Blom A. M., Villoutreix B. O., Dahlback B.

Archivum Immunologiae et Therapiae Experimentalis

|

2004

|

tom 52

|

nr 2

8

Glycosaminoglycans of human serum and their alterations in diabetes mellitus

86%

Kozma E. M., Olczyk K., Glowacki A., Komosinska K., Sonecki P., Najmiec T., Jazwiec M.

Acta Biochimica Polonica

|

1996

|

tom 43

|

nr 3

Human serum contains several glycosaminoglycans (GAGs), mainly chondroitin sulphates and significantly less of heparan sulphate + heparin and dermatan sulphate. The non-insulin-dependent diabetes mellitus (with vascular complications) was associated with a significant increase in total serum GAG concentration, mainly of chondroitin sulphates and dermatan sulphate, with a simultaneous decrease in heparan sulphate + heparin level. These alterations were much more evident in patients with poor metabolic control. Hyaluronic acid (undetectable in healthy subjects and in patients with good metabolic control) appeared only in trace amounts in poorly controlled diabetic individuals. The obtained data allow to conclude that the diabetes mellitus-associated disturbances in tissue GAG metabolism lead to significant alterations in serum GAG composition.

9

Effect of unfractionated heparin, enoxaparin and sulodexide on the relations between secretion and expression of OPG, RANKL and vWF in HUVEC

72%

Lekesiz K., Naumnik B., Borysewicz-Sanczyk H., Koc-Zorawska E., Mysliwiec M.

Folia Histochemica et Cytobiologica

|

2013

|

tom 51

|

nr 2

10

The current view on biological potency of cationically modified chitosan

72%

Stefan J., Lorkowska-Zawicka B., Kaminski K., Szczubialka K., Nowakowska M., Korbut R.

Journal of Physiology and Pharmacology

|

2014

|

tom 65

|

nr 3

11

Mechanisms for the formation of membranous nanostructures in cell-to-cell communication

72%

Schara K., Jansa V., Sustar V., Dolinar D., Pavlic J. I., Lokar M., Kralj-Iglic V., Veranic P., Iglic A.

Cellular and Molecular Biology Letters

|

2009

|

tom 14

|

nr 4

636-656

Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we describe two physical mechanisms involved in the formation of microvesicles and nanotubes: curvature-mediated lateral redistribution of membrane components with the formation of membrane nanodomains; and plasmamediated attractive forces between membranes. These mechanisms are clinically relevant since they can be affected by drugs. In particular, the underlying mechanism of heparin’s role as an anticoagulant and tumor suppressor is the suppression of microvesicluation due to plasma-mediated attractive interaction between membranes.

12

The influence of unfractionated and low-molecular weight heparins on the properties of human umbilical vein endothelial cells [HUVEC]

72%

Gasowska K., Naumnik B., Klejna K., Mysliwiec M.

Folia Histochemica et Cytobiologica

|

2009

|

tom 47

|

nr 1

17-23

13

Catalytic activity of mutants of yeast protein kinase CK2alpha

72%

Sajnaga E., Kubinski K., Szyszka R.

Acta Biochimica Polonica

|

2008

|

tom 55

|

nr 4

767-776

Yeast CK2 is a highly conserved member of the protein kinase CGMC subfamily composed of two catalytic (α and α′) and two regulatory (β and β′) subunits. The amino-acid sequences of both catalytic subunits are only 60% homologous. Modelling of the tertiary structure of the CK2α displays additional α-helical structures not present in the CK2α′ subunit, connecting the ATP-binding loop with the catalytic and activation loops. Deletion of this part causes drastic structural and enzymatic changes of the protein (CK2α∆91–128) with characteristics similar to yeast CK2α′ (low sensitivity to salt, heparin and spermine). Additionally, the deletion causes an over 5-fold decrease of the binding affinity for ATP and ATP-competitive inhibitors (TBBt and TBBz). The structural basis for TBBt and TBBz selectivity is provided by the hydrophobic pocket adjacent to the ATP/GTP binding site, which is smaller in CK2 than in the majority of other protein kinases. The importance of hydrophobic interactions in the binding of specific inhibitors was investigated here by mutational analysis of CK2α residues whose side chains contribute to reducing the size of the hydrophobic pocket. Site-directed mutagenesis was used to replace Val67 and Ile213 by Ala. The kinetic properties of the single mutants CK2αVal67Ala and CK2αIle213Ala, and the double mutant CK2Val67Ala Ile213Ala were studied with respect to ATP, and both inhibitors TBBt and TBBz. The Km values for ATP did not change or were very close to those of the parental kinase. In contrast, all CK2α mutants analysed displayed higher Kivalues towards the inhibitors (10 to 12-fold higher with TBBt and 3 to 6-fold with TBBt) comparing to recombinant wild-type CK2α.

14

Heparin inhibits protective effect of ischemic preconditioning in ischemia/reperfusion-induced acute pancreatitis

72%

Warzecha Z., Dembinski A., Ceranowicz P., Dembinski M., Sendur R., Cieszkowski J., Sendur P., Tomaszewska R.

Journal of Physiology and Pharmacology

|

2012

|

tom 63

|

nr 4

15

Heparin- and Zn2plus -binding proteins from boar seminal plasma

72%

Holody D., Strzezek J.

Acta Biochimica Polonica

|

1999

|

tom 46

|

nr 4

Low molecular mass, heparin-binding proteins from seminal plasma play an important role in gametes interaction whereas plasmatic Zn2+-binding proteins stabilize chromatin and plasmalemma structures and protect spermatozoa in the female reproductive tract. By means of affinity chromatography the heparin- and Zn2+-binding proteins were isolated from boar seminal plasma and both preparations were analyzed by reverse HPLC. Most of the proteins bound to heparine and Zn2+-ions were classified as spermadhesins. Three fractions binding exclusively Zn2+ were isolated. They differ in amino-acid composition, content of glucosamine and content of protein components revealed by SDS/PAGE.

16

Microcirculatory disturbances in caerulein-induced acute pancreatitis in rats with reference to nitric oxide, heparin and procaine treatment

72%

Dobosz M., Hac S., Wajda Z., Rzepko R., Roszkiewicz A., Zawrocka-Wrzolek T.

Journal of Physiology and Pharmacology. Supplement

|

1998

|

tom 49

|

nr 2

17

Oral heparin in the treatment of rheumatoid arthritis

72%

Imiela J., Nosarzewski J., Gorski A.

Archivum Immunologiae et Therapiae Experimentalis

|

1995

|

tom 43

|

nr 5-6

18

Low dose heparin: efficacious treatment for chronic renal allograft rejection

72%

Gradowska L., Lao M., Morzycka-Michalik M., Gorski A.

Archivum Immunologiae et Therapiae Experimentalis

|

1993

|

tom 41

|

nr 2

19

Nitric oxide, heparin and procaine treatment in experimental ceruleine-induced acute pancreatitis in rats

72%

Dobosz M., Wajda Z., Hac S., Mysliwska J., Bryl E., Mionskowska L., Roszkiewicz A., Mysliwski A.

Archivum Immunologiae et Therapiae Experimentalis

|

1999

|

tom 47

|

nr 3

20

Heparin modulates migration of human peripheral blood mononuclear cells and neutrophils

72%

Zak-Nejmark T., Krasnowska M., Jankowska R., Jutel M.

Archivum Immunologiae et Therapiae Experimentalis

|

1999

|

tom 47

|

nr 4

Ograniczanie wyników

The pinocytosis in amoeba proteus induced by subthreshold concentration of heparin

Heparin enhances generation of natural killer activity in vitro

Phosphorylation of yeast ribosomal proteins by CKI and CHII in the presence of heparin

Protective and therapeutic effect of heparin in acute pancreatitis

Pharmacogenetic considerations of anticoagulant medication

Effect of heparin on the course of sulphur dioxide induced bronchitis in rats

Functions of human complement inhibitor C4b-binding protein in relation to its structure

Glycosaminoglycans of human serum and their alterations in diabetes mellitus

Effect of unfractionated heparin, enoxaparin and sulodexide on the relations between secretion and expression of OPG, RANKL and vWF in HUVEC

The current view on biological potency of cationically modified chitosan

Mechanisms for the formation of membranous nanostructures in cell-to-cell communication

The influence of unfractionated and low-molecular weight heparins on the properties of human umbilical vein endothelial cells [HUVEC]

Catalytic activity of mutants of yeast protein kinase CK2alpha

Heparin inhibits protective effect of ischemic preconditioning in ischemia/reperfusion-induced acute pancreatitis

Heparin- and Zn2plus -binding proteins from boar seminal plasma

Microcirculatory disturbances in caerulein-induced acute pancreatitis in rats with reference to nitric oxide, heparin and procaine treatment

Oral heparin in the treatment of rheumatoid arthritis

Low dose heparin: efficacious treatment for chronic renal allograft rejection

Nitric oxide, heparin and procaine treatment in experimental ceruleine-induced acute pancreatitis in rats

Heparin modulates migration of human peripheral blood mononuclear cells and neutrophils