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The influence of sevoflurane on the reactivity of astrocytes in the course of the experimental intracerebral haemorrhage in rat

100%

Karwacki Z., Kowianski P., Dziewiatkowski J., Domaradzka-Pytel B., Ludkiewicz B., Wojcik S., Narkiewicz O., Morys J.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 3

40 adult Wistar rats were divided into two groups depending on the applied anaesthesia. In both groups animals were generally anaesthetized with fentanyl, dehydrobenzperidol administered intraperitoneally and midazolam given intramuscularly. In the second group (SEVO) animals received sevoflurane of 2.2 vol% end-tidal concentration. Intracerebral haematoma was produced through infusion of 100 µl of autologous blood into the striatum. Each group was divided into five subgroups depending on the length of survival period: 1, 3, 7, 14, 21 days. The astrocytic population was studied by means of anti-GFAP staining. Stereological analysis was applied to estimate the numerical density of immunoreactive cells and the distribution of their types. On 7th day of observation the density of GFAP-immunoreactive astrocytes in SEVO was lower (p<0,05) than that in the control group. In the control group, the increase (p<0.05) of per cent of activated astrocytes between the 1st and 3rd survival day was noted, which remained at this level till the end of observation. In SEVO group, the increase (p<0.05) of per cent of activated astrocytes between the 3rd and 7th day and the decrease (p<0.05) between the 14th and 21st survival day were observed. During days of observation the per cent of activated astrocytes was lower (p<0.05) in the SEVO group than that in the control group. Administration of sevoflurane during anaesthesia to animals with intracerebral haemorrhage has evoked not only the delay of the activation of astrocytes but also decrease in its level.

2

Centrally applied vasopressin intensifies hypotension and bradycardia after hemorrhage in SHR rats

86%

Dobruch J., Paczwa P., Lon S., Szczepanska-Sadowska E.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 2

Spontaneuosly hypertensive rats (SHR) have been shown to exhibit several alterations in function of the intrabrain vasopressinergic system. The present study was designed to find out whether centrally administered vasopressin (AVP) may influence the cardiovascular adaptation to hypotensive hypovolemia in SHR rats. Two series of experiments were performed on conscious 17 SHR rats chronically implanted with lateral cerebral ventricle (LCV) cannulas and with femoral artery catheters. Mean arterial pressure (MAP) and heart rate (HR) were monitored before and after arterial bleeding (1,3% body weight) performed during LCV infusion of 1) artificial cerebrospinal fluid 5µl/hour (aCSF); and 2) arginine vasopressin, 100ng/hour/5µl of aCSF (AVP). Central administration of aCSF and AVP had no effect on MAP and HR under resting conditions. Hemorrhage evoked significant hypotension (p<0.001) and bradycardia (p<0.001). During central infusion of AVP hemorrhage resulted in significantly greater hypotension than during central infusion of aCSF alone (p<0,05). The results provide evidence that centrally applied vasopressin significantly modulates cardivascular adjustments to hypotensive hemorrhage in SHR.

3

Leptospirosis in West Pomeranian district in Poland

86%

Niscigorska J., Moranska I., Kruszewski T., Boron-Kaczmarska A.

Advances in Agricultural Sciences

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2004

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tom 09

4

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Insulin-like immunoreactivity [IRI] the rat hypothalamo-neurohypophysial system: effect of dehydration and haemorrhage

86%

Stempniak B., Guzek J. W.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 2

5

An observational cohort study of 3 units versus 5 units slow intravenous bolus oxytocin in women undergoing elective caesarean delivery

72%

Terblanche N., Otahal P., Messmer A., Wright P., Patel S., Nathan K., Sharman J. E.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 4

6

Galanin affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in haemorrhaged rats

72%

Ciosek J., Cisowska A., Dabrowski R.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 2

The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats. Gal i.c.v. treatment did not alter vasopressin and oxytocin content both in the hypothalamus and neurohypophysis as well as their concentration in blood plasma of not haemorrhaged rats. Haemorrhage decreased the hypothalamic and neurohypophysial vasopressin and oxytocin storage but increased the neurohormones plasma level in animals injected with vehicle solution. During the haemorrhage, the increase in plasma vasopressin and oxytocin was inhibited in rats previously treated i.c.v. with galanin. The hypothalamic and neurohypophysial vasopressin as well as oxytocin content significantly increased in animals treated with galanin and subsequently haemorrhaged. These results suggest that galanin may have a regulatory role in the hypothalamo-neurohypophysial function especially under condition of hypovolemia.

7

Atrial natriuretic peptide inhibits neurohypophysial hormones' release in rat [in vitro and in vivo studies]

72%

Lewandowska A., Szyburska I., Guzek J. W.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 1

Intracerebroventricular hANP (50 nmol) inhibits release of vasopressin and oxytocin following dehydration as well as after haemorrhage. 10 nmol/L hANP markedly inhibits vasopressin arid oxytocin release in vitro from the neurointermediate lobes both under basal condition as well as during stimulation with excess (56 mM) potassium. It is suggested that ANP may serve as a modulator of vasopressin and oxytocin release. The respective processes are localized, at least in part, at the neurohypophysial level.

8

The vasopressin and oxytocin neurohypophysial content as influenced by bleeding or dehydration: effect of cholecystokinin octapeptide

72%

Lewandowska A., Glowacka A., Guzek J. W.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 2

The effect of CCK-8 (50 ng, i. c. v.) on the neurohypophysial vasopressin and oxytocin storage was estimated in haemorrhaged (1 ml per 100 g b. w.) male Wistar rats. In another experimental series rats dehydrated for three days were given CCK-8 in a daily i. c. v. dose of 50 ng. The neurohypophysial vasopressin and oxytocin content was bioassayed by pressor effect following Dekański or milk- ejection activity in vitro following van Dongen and Hays, respectively. The decrease of neurohypophysial vasopressin and oxytocin content, brought about by dehydration, was significantly less marked in animals treated with CCK-8. The depletion of neurohypophysial vasopressin and oxytocin content in haemorrhaged animals could be completely inhibited by earlier i. c. v. administration of CCK-8. It is suggested that hypothalamic cholecystokinin may serve as a modulator of neurohypophysial function.

9

Physiologic, metabolic and mediator responses in posttrauma ards and sepsis; is oxygen debt a critical initiating factor?

58%

Siegel J. H.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 4

10

Regional heterogeneity of myocardial blood flow within the rabbit left ventricle during haemorrhagic hypotension

58%

Standa M., Iversen P. O., Flatebo T., Nicolaysen G.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 3

Several studies have reported an extensive regional heterogeneity in myocardial blood flow. The reported coefficients of variation for regional myocardial perfusion range from about 0.2 to 0.4 in normotensive animals. The spatial distribution of myocardial perfusion during haemorrhagic hypotension seems not to have been assessed. The goal of the present study was to determine the regional heterogeneity in myocardial blood flow within the rabbit left ventricle during normal conditions and after haemorrhagic hypotension. Radioactive microspheres were infused into the left ventricle in barbiturate anaethetized rabbits over either 30 or 120 sec. The haemorrhagic hypotension was induced by bleeding, so that mean arterial blood pressure was reduced to about 50% of control. The left ventricles were divided into samples of about 0.025 g each. Regional heterogeneity in the blood flow was expressed as the coefficient of variation corrected for the Poisspn distribution of microspheres (CVc). The CVc was 0.37 ±0.09 (mean±SD) during control and 0.41+0.11 after bleeding, the CVc obtained after bleeding being somewhat higher than during control (P<0.05). We obtained a high correlation coefficient (τ about 0.68) between regional perfusion values at control and after bleeding which indicates a stable perfusion pattern within the myocardium. We conclude that the regional distribution of coronary blood flow within the left ventricle is markedly heterogenous during control condition and that this pattern is not changed during haemorrhagic hypotension.

11

Zagrożenia podczas znieczulenia ogólnego u koni

37%

Siwinska N., Przewozny M.

Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii

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2015

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tom 10

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nr 2

12

Co zrobić, jeżeli pacjent może nie przeżyć transportu

37%

Stilwell N.

Weterynaria po Dyplomie

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2020

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tom 21

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nr 5

Ograniczanie wyników

The influence of sevoflurane on the reactivity of astrocytes in the course of the experimental intracerebral haemorrhage in rat

Centrally applied vasopressin intensifies hypotension and bradycardia after hemorrhage in SHR rats

Leptospirosis in West Pomeranian district in Poland

Insulin-like immunoreactivity [IRI] the rat hypothalamo-neurohypophysial system: effect of dehydration and haemorrhage

An observational cohort study of 3 units versus 5 units slow intravenous bolus oxytocin in women undergoing elective caesarean delivery

Galanin affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in haemorrhaged rats

Atrial natriuretic peptide inhibits neurohypophysial hormones' release in rat [in vitro and in vivo studies]

The vasopressin and oxytocin neurohypophysial content as influenced by bleeding or dehydration: effect of cholecystokinin octapeptide

Physiologic, metabolic and mediator responses in posttrauma ards and sepsis; is oxygen debt a critical initiating factor?

Regional heterogeneity of myocardial blood flow within the rabbit left ventricle during haemorrhagic hypotension

Zagrożenia podczas znieczulenia ogólnego u koni

Co zrobić, jeżeli pacjent może nie przeżyć transportu