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1

Role of penicillin binding proteins in penicillin allergy

100%
Zdziarski P.
Polish Journal of Microbiology
|
2004
|
tom 53
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nr 4
All (β-lactam sensitive bacteria contain enzymatic penicillin binding proteins (PBPs), which are membrane-bound enzymes and targets of β-lactam antibiotics. In this work evaluation of the significance of PBPs in immune response to benzylpenicillin was presented. 35 patients with allergic reactions to penicillin and 17 subjects without penicillin allergy, but exposed, were studied. Proliferative T-cell responses to benzylpenicillin, penicillin and PBPs conjugates (Pc-PBPs) from E. coli, K. oxytoca, S. aureus, S. epidermidis or serum protein (Pc-S) were measured. Although each allergic individual responds to Pc-PBPs in several different ways, specific proliferation of T lymphocytes with Pc-PBPs from bacterial membranes was significant higher than with Pc or Pc-S. This observation gives us a real insight into the causes of the drug allergy: individual allergic reaction and susceptibility to the drug is in strict correlation with bacterial infection. It seems likely that acylation of PBPs could be the trigger for primary immune response to the hapten benzylpenicillin.
2
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Databases and associated bioinformatic tools in studies of food allergens, epitopes and haptens - a review

72%
Bucholska J., Minkiewicz P., Darewicz M., Iwaniak A.
Polish Journal of Food and Nutrition Sciences
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2018
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tom 68
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nr 2
Allergies and/or food intolerances are a growing problem of the modern world. Diffi culties associated with the correct diagnosis of food allergies result in the need to classify the factors causing allergies and allergens themselves. Therefore, internet databases and other bioinformatic tools play a special role in deepening knowledge of biologically-important compounds. Internet repositories, as a source of information on different chemical compounds, including those related to allergy and intolerance, are increasingly being used by scientists. Bioinformatic methods play a signifi cant role in biological and medical sciences, and their importance in food science is increasing. This study aimed at presenting selected databases and tools of bioinformatic analysis useful in research on food allergies, allergens (11 databases), epitopes (7 databases), and haptens (2 databases). It also presents examples of the application of computer methods in studies related to allergies.
3

Involvement of haptens in allergic and non-allergic hypersensitivity

58%
Kucharska E., Bober J., Jedrychowski L.
Polish Journal of Environmental Studies
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2009
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tom 18
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nr 3
325-330
The environment is used as a broad umbrella term for all sources of allergens which may cause allergic hypersensitive reaction of the immune system of humans. Westernization of life leads to increased average consumption of food additives (natural and xenobiotics) – starting from over 5kg (10lbs) annually with a strong tendency to intensify. Modern technologies of food production often employ substances improving quality, texture, colour, taste, acidity or alkalinity. Haptens present in food or drugs, penetrating organism via gastrointestinal tract, may be responsible for symptoms not only in the gastrointestinal tract itself, but also in peripheral organs. Mechanisms of hapten action within human body are different – they include reactions when the immune system is involved (allergic hypersensitivity) and not involved (food intolerance also known as non-allergic hypersensitivity). Food intolerance is a more frequent phenomenon diagnosed in 20-50% of cases; food allergy affecting 6-8% children and 1-2% adults. Our work elucidates mechanisms of hypersensitivity responses to haptens, and characterizes major haptens applied as food additives.
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