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Medycyna Weterynaryjna
|
2010
|
tom 66
|
nr 07
s.489-494,fot.,tab.,bibliogr.
The aim of this work was to evaluate the histopathological changes in dog adrenals with a special attention to cortical-cell lipidosis. The routine histopathological examinations were performed in adrenals, which were obtained post mortem from 50 dogs of both sexes, 1-22 years old. The research revealed the presence of lipidosis in the cells of zona reticulosa, and/or proliferation of cortical cells. The type of proliferation was variable, from simple hyperplasia related to hyperstimulation of the secretion of cortical cells up to benign or malignant neoplasms. A special attention was paid to the lipidosis of cortex cells. This type of degenerative changes results from disturbances in the cell lipid metabolism. The affected cells were observed in dogs older than 1 year, and their number increased with the animal’s age. Lipidosis alone was found in 8% cases, in 16% cases it was combined with hyperplasia of cortex cells, and in 30% cases it was accompanied by a neoplastic growth. Pathological accumulation of cytoplasmic lipids may result from metabolic disturbances due to the exposure to various toxic substances. The pathologic process may lead to the necrobiosis of cell nuclei. In the adrenals examined, lipidosis affected the cells in zona reticularis. Lipidosis did not appear to be related to the sex of the dogs, but the degeneration tended to increase in older dogs. It must be stressed, however, that in about half the cases examined (36%) lipidosis was not observed in adrenals with hyperplastic or neoplastic changes.
The aim of the study was to estimate the prevalence and localization of different type of endocrine tumors in domestic animals in relation to age, sex and the breed of animals. The tissue specimens obtained during surgical procedures and necropsy materials were submitted to the Division of Pathomorphology, Faculty of Veterinary Medicine, Department of Clinical Sciences, Warsaw University of Life Sciences - WULS, from 1996-2007, for histopathological examinations. The tissue samples for histopathology were fixed in 10% buffered formalin, embedded in paraffin, 4 µm-thick sections were stained with haematoxylin and eosin method or others if needed. A total of 97 tumors were evaluated in this retrospective study. Most cases of endocrine tumors were found in dogs (84.5%), less in cats (8.2%), horses, domestic ferrets, goats (2.1% each species) and rats (1.0%). Over 60% of endocrine tumors were localized in the thyroid gland, especially in dogs (91.5% of all thyroid tumors), then in cats, more seldom in horses. They were prevalent in old age and were observed in both sexes. The breed prevalences of canine thyroid tumors were noted in dachshunds (20.4%). Adrenal gland (39.2%) were the second most frequent endocrine tumors predilection site. Adrenal gland tumors often appeared in dogs (34.1% of all canine endocrine tumors), rarely in cats, then in domestic ferrets, goats, rats. Malignant endocrine neoplasms were noted in 62.9% of the cases. More often malignant epithelial neoplasms were found in the thyroid. The majority of nonmalignant epithelial neoplasms (adenomas) were localized in adrenal glands. It is also worth noting rare cases animal tumors: thyroid oncocytoma and medullary thyroid carcinoma.
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