Wyniki wyszukiwania

1

The expression of GST isoenzymes and p53 in non-small cell lung cancer

100%

Oguztuzun S., Aydin M., Demirag F., Yazici U., Ozhavzali M., Kilic M., Iscan M.

Folia Histochemica et Cytobiologica

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2010

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tom 48

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nr 1

122-127

2

Role of glutathione in chalcone derivative induced apoptosis of Brugia malayi and its possible therapeutic implication

100%

Bhoj P. S., Bahekar S., Khatri V., Singh N., Togre N. S., Goswami K., Chandak H. S., Dash D.

Acta Parasitologica

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2021

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tom 66

|

nr 2

3

Certain protein transducing agents convert translocated proteins into cell killers

84%

Tcherniuk S., Fiser A.-L., Derouazi M., Toussaint B., Wang Y., Wojtal I., Kondo E., Szolajska E., Chroboczek J.

Acta Biochimica Polonica

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2012

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tom 59

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nr 3

The majority of proteins are unable to translocate into the cell interior. Hence for peptide- and protein-based therapeutics a direct intracytoplasmic delivery with the aid of transducing agents is an attractive approach. We wanted to deliver to the cell interior a putatively cytotoxic protein VPg. Protein transduction was achieved in vitro with three different commercial products. However, in our hands, delivery of various control proteins without known deleterious effects, as well as of protein VPg, always induced cell death. Finally, we used a novel transducing peptide Wr-T, which was not toxic to cultured cells, even in a quite large range of concentrations. Most importantly, control protein delivered to cells in culture did not display any toxicity while VPg protein exerted a strong cytotoxic effect. These data show that results obtained with cell-penetrating agents should be interpreted with caution.

4

Comparative effect of pioglitazone, quercetin and hydroxy citric acid on the status of lipid peroxidation and antioxidants in experimental non-alcoholic steatohepatitis

67%

Surapaneni K. M., Jainu M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 1

5

Sesbania grandiflora diminishes oxidative stress and ameliorates antioxidant capacity in liver and kidney of rats exposed to cigarette smoke

59%

Ramesh T., Sureka C., Bhuvana S., Hazeena Begum V.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 4

467-476

Cigarette smoke is a major risk factor for many chronic diseases. However, it may be possible to relieve the smoke-induced damage by increasing the defensive system. In this study, we planned to evaluate the protective mechanism of Sesbania grandiflora (S. grandiflora) leaves against cigarette smoke-induced oxidative damage in liver and kidney of rats. Adult male Wistar-Kyoto rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with S. grandiflora aqueous suspension (SGAS, 1000 mg/kg body weight per day by oral gavage) for a period of 3 weeks. Hepatic marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), as well as renal markers such as urea and creatinine were analysed in serum. Lipid peroxidation marker mainly thiobarbituric acid reactive substances (TBARS) and antioxidant enzymes namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) activities and non-enzymatic antioxidants such as reduced glutathione, ascorbic acid and a-tocopherol levels were studied. In addition, micronutrients mainly copper (Cu), zinc (Zn), manganese (Mn) and selenium (Se) levels were analyzed in liver and kidney of rats exposed to cigarette smoke. The results indicated that SGAS significantly decreased the elevated hepatic, renal and lipid peroxidation markers and ameliorated the diminished antioxidant levels while restored the hepatic and renal architecture in cigarette smoke-exposed rats. This study concludes that S. grandiflora leaves restrain cigarette smoke-induced oxidative damage in liver and kidney of rats.

Ograniczanie wyników

The expression of GST isoenzymes and p53 in non-small cell lung cancer

Role of glutathione in chalcone derivative induced apoptosis of Brugia malayi and its possible therapeutic implication

Certain protein transducing agents convert translocated proteins into cell killers

Comparative effect of pioglitazone, quercetin and hydroxy citric acid on the status of lipid peroxidation and antioxidants in experimental non-alcoholic steatohepatitis

Sesbania grandiflora diminishes oxidative stress and ameliorates antioxidant capacity in liver and kidney of rats exposed to cigarette smoke