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Non-enzymatic antioxidative defence mechanism in plasma of pigs during periparturient period: vitamin C and glutathione

100%

Szczubial M.

Bulletin of the Veterinary Institute in Puławy

2010

tom 54

nr 3

The aim of the study was to determine plasma levels of vitamin C and reduced glutathione (GSH) in sows between the day 14 prepartum and day 14 postpartum. The study involved twenty-four sows of three breeds - Polish Large White (PLW), Polish Landrace (PL) and PLWxPL aged 1-3 years. All the animals were from one closed-cycle production farm. The mean vitamin C level on days 13-14 prepartum reached 0.49 ±0.19 mmol/g of protein and decreased significantly (P<05) at 24-48 h postpartum to 0.33 ±0.19 mmol/g of protein. On days 6-7 and 13-14 postpartum, the vitamin C level further decreased to 0.17 ±0.006 and 0.15 ±0.007 mmol/g of protein, respectively. The mean GSH level on days 13-14 before delivery was 0.071 ±0.009 mmol/g of protein and decreased significantly (P0.05) at 24-48 h before delivery to 0.062 ±0.018 mmol/g of protein. In this period, the mean GSH level was similar to that observed during the first 24-48 h postpartum. On day 6-7 after delivery, the level of GSH reached the values observed on days 13-14 and 6-7 prepartum. On days 13-14 postpartum, the level of GSH was found to be 0.115 ±0.029 mmol/g of protein and was significantly higher (P<0.001) compared to that on days 13-14 prepartum. The findings suggest that porcine levels of vitamin C and glutathione decrease during the periparturient period, which may lead to a decreased antioxidant defence system and an imbalance in redox homeostasis.

Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise

100%

Zembron-Lacny A., Slowinska-Lisowska M., Szygula Z., Witkowski K., Stefaniak T., Dziubek W.

Journal of Physiology and Pharmacology

2009

tom 60

nr 2

139-143

The aim of this study was to compare the indices of glutathione antioxidant system and oxidative damage level in resistance trained and untrained subjects and to assess the antioxidant action of -lipoic acid in trained men exposed to muscle-damaging exercise. Thirteen trained and twenty untrained men (NT) participated in the comparative study. Then trained men were randomly assigned to TCON group (control) or TALA group (-lipoic acid, 600 mg . day-1, for 8 days) and performed isometric/isokinetic effort of quadriceps muscles. The study has shown the significantly higher erythrocyte levels of glutathione (GSH), glutathione reductase (GR) and glutathione peroxidase (GPx) in TCON than NT but no differences in plasma lipid peroxidation (TBARS) and protein carbonylation (PC). However, total thiol (TT) concentration was two-fold lower in TCON than NT group. -Lipoic acid variously influenced the post-exercise levels of GSH (+40%), GR (-24%) and GPx (+29%), but markedly reduced by over 30% the resting and post-exercise TBARS and PC in TALA compared with TCON. TT concentration significantly increased in TALA but it did not reach the high level which was found in untrained group. It is concluded that -lipoic acid supplementation diminishes oxidative damage. It does not abolish differences in glutathione antioxidant system between untrained and trained subjects but modulates a pro-antioxidant response to the muscle-damaging exercise.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Journal of Physiology and Pharmacology

1 Dziubek W.

1 Slowinska-Lisowska M.

1 Stefaniak T.

1 Szczubial M.

1 Szygula Z.

1 Witkowski K.

1 Zembron-Lacny A.

1 2010

1 2009

Wyniki wyszukiwania

Non-enzymatic antioxidative defence mechanism in plasma of pigs during periparturient period: vitamin C and glutathione

Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise