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Age dependence of plasma endothelin levels in glaucoma patients

100%
Konieczka K., Terelak-Borys B., Skonieczna K., Schoetzau A., Grabska-Liberek I.
Journal of Physiology and Pharmacology
|
2020
|
tom 71
|
nr 6
2

HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma

84%
Reszec J., Zalewska R., Bernaczyk P., Chyczewski L.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 3
3

DNA damage and alterations of gene expression in chronic-degenerative diseases

84%
Izzotti A.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 1
Chronic-degenerative diseases (CDD) recognise a variety of exogenous and endoge­nous risk factors interacting with the organism for many years before disease onset. We applied genomic and postgenomic molecular analyses in experimental models characterised by different contribution of exogenous and endogenous CDD risk fac­tors. Exposure of mice to halogen light for 28 days resulted in induction of cyclobutane dimers and oxidative DNA damage in the skin. Evaluation of postgenomic alterations by cDNA arrays revealed upregulation of DNA repair pathways, increased cell divi­sion rate and protooncogenes transcription, resulting in skin tumors, 1 year later. Exposure of p53-/+ mutant mice to cigarette smoke (CS) for 28 days induced DNA adducts formation in the lung. Postgenomic alterations included decreased apoptosis and increased cell division, as compared to CS-exposed wild type mice. These phenom­ena resulted in lung tumors, 9 months later. Transplacental exposure of mouse foetuses to cigarette smoke induced DNA adduct formation in the liver. cDNA arrays analyses demonstrated decreased cell division, apoptosis increase, and tissue hypoxia. These phenomena resulted in growth retarda­tion of the whole organism. Molecular alterations were investigated in human trabecular meshwork, the non-replicating ocular epithelia involved in the pathogenesis of chronic degenerative glaucoma. Results indicate increased oxidative DNA damage in glaucoma patients as compared to unaffected controls.
4

Short-term results of Ahmed glaucoma valve implantation in the surgical treatment of angle-recession glaucoma in dog

67%
Lew M., Lew S., Brzeski W.
Polish Journal of Veterinary Sciences
|
2008
|
tom 11
|
nr 4
377-383
Angle-recession glaucoma, being a consequence of blunt injury of an eyeball, is likely to develop in both a short or very distant period. The likelihood of the incidence of that condition in the clinical form is determined by the extent of injuries of ciliary cleft structures, especially of a trabecular meshwork. The manuscript reports a case of an early glaucoma secondary to a blunt injury of an eyeball with symptoms of angle recession to 300° of periphery and intraocular pressure (IOP) at a level of 62 mmHg. The basic diagnostic examination that enables the evaluation of an angle, iris root and an opening to the ciliary cleft is gonioscopy. In case of a lack of response to the pharmacological reduction of IOP, a method of choice still remains a surgical procedure. In the reported case, a drainage procedure was applied in the form of implantation of the Ahmed valve prosthesis. Control tonometric examinations of the operated eye, performed over a 20-week period of postoperative management, demonstrated IOP at a level of 19 mmHg.
5

Cyclodialysis in the treatment of nonhealing secondary glaucoma

67%
Lew M., Lew S.
Polish Journal of Veterinary Sciences
|
2008
|
tom 11
|
nr 4
371-375
In cases of glaucoma with elevated intra ocular pressure, the first objective of treatment is its reduction and normalization. In cases when excessive pressure has resulted in a loss of vision, the aim of treatment is to attenuate the pain and to improve the comfort of the patient. This paper presents a case of glaucoma secondary to anterior uveitis, resistant to pharmacological treatment. A gonioscopic examination in both eyes revealed a narrowed filtration angle. An ophthalmoscopic examination of the fundus showed partial retinal detachment. The cyclodialysis procedure was performed in both eyes. In the post-surgery period, intraocular pressure (IOP) in both eyes showed a downward tendency. The treatment of glaucoma secondary to anterior uveitis, particularly in its advanced state, often requires the combination of pharmacological treatment with a surgical procedure. Positive results in maintaining the patency of the fistula were observed after the application of a steroid therapy and a regular massage of filtration bleb, which significantly contributed to maintaining IOP at a desired level.
6

Serotonin and melatonin in the iris-ciliary processes and their involvement in intraocular pressure

67%
Osborne N. N.
Acta Neurobiologiae Experimentalis
|
1994
|
tom 54
|
nr S
7

Rozpoznawanie nagłej ślepoty u psów

34%
Plummer C. E.
Weterynaria po Dyplomie
|
2018
|
tom 19
|
nr 1
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