Wyniki wyszukiwania

1

Cystic fibrosis is a risk factor for celiac disease

100%

Walkowiak J., Blask-Osipa A., Lisowska A., Oralewska B., Pogorzelski A., Cichy W., Sapiejka E., Kowalska M., Korzon M., Szaflarska-Poplawska A.

Acta Biochimica Polonica

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2010

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tom 57

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nr 1

115-118

Background: The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence of CD in CF patients to that in the general population at the same time. There is no published data on genetic predisposition to CD in CF patients either. Therefore, in the present study we aimed to assess the genetic predisposition to CD and its incidence in CF patients comparing it to data from the general population. Patients and methods: Two hundred eighty-two CF patients were enrolled in the study. In 230 CF patients the genetic predisposition to CD (the presence of HLA-DQ2/ DQ8) was assessed. In all CF patients, serological screening for CD was conducted. In patients with positive antiendomysial antibodies (EMA) gastroduenoscopy was offered. Intestinal histology was classified according to modified Marsh criteria. The results of serological CD screening in 3235 Polish schoolchildren and HLA-DQ typing in 200 healthy subjects (HS) were used for comparison. Results: Positive EMA was found in 2.84 % of the studied CF patients. The incidence of proven CD was 2.13 %. The incidence of CD as well as positive serological screening were significantly more frequent in the CF group than in the general population. The frequency of CD-related HLA-DQ alleles in CF and HS did not differ. Conclusions: Genetic predisposition to celiac disease in cystic fibrosis patients is similar to that of the general population. However, our results suggest that cystic fibrosis is a risk factor for celiac disease development.

2

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Genetic predisposition to breast and/or ovarian cancer – focus on the candidate BARD1 gene

86%

Klonowska K., Ratajska M., Wojciechowska M., Kozlowski P.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2014

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tom 95

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nr 3

3

Correction of the antebrachial deformity using circular external skeletal fixator in 7 dogs

86%

Captug O., Bilgili H.

Polish Journal of Veterinary Sciences

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2009

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tom 12

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nr 1

This study was carried out on 7 dogs with antebrachial deformity caused by malunion on radius-ulna fracture, treated with the Ilizarov method. The 1st, 3rd and 5th case were progressive correction group, in which the fixation consisted of a two-ring frame hinged with a ring in 100 mm diameter. The 2nd, 4th, 6th and 7th case were acute correction group, applied on a plain three-ring, non-hinged apparatus with the ring diameter of 80 mm. In the progressive correction group, the hinged fixator was placed in such a position that two rings would be localized on the proximal fragment and third on the distal fragment, whilst the site of osteotomy would be between the 2nd and 3rd rings after a bone segment removed. In the acute correction group, two rings were located on the proximal fragment with the third on the distal fragment, and the osteotomy was in the same position. The cases started using their extremities in postoperative days 1-8 (mean 2.5 days), and the initial weight bearing was observed on the postoperative days 18-28 (mean 18.5 days). The radiographic examinations revealed that antebrachial deformity and shortness of the extremity was corrected, and the consolidation was completed in postoperative days 35-50 (mean 40.7 days). In conclusion, using the Ilizarov apparatus for the acute correction of antebrachial deformities can provide faster, better and more practical treatment than more progressive correction with the hinged-apparatus. Provided that enough attention is paid during this acute treatment, flexion contracture can be avoided.

4

Association between alpha-adducin gene polymorphism [Gly460Trp] and genetic predisposition to salt sensitivity: a meta-analysis

72%

Wang R., Zhong B., Liu Y., Wang C.

Journal of Applied Genetics

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2010

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tom 51

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nr 1

87-94

Linkage and association studies suggested the relationship between α-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and α-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96,2.04), P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI): 1.33 (1.06, 1.69), P = 0.02] but not in Caucasian people [OR (95%CI): 1.98 (0.57, 6.92), P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of α-adducin Gly460Trp polymorphism in salt-sensitive hypertension.

5

The impact of sex and age on the prevalence of clinically relevant sensitization and asymptomatic sensitization in the general population

72%

Dor-Wojnarowska A., Liebhart J., Miecielica J., Rabski M., Fal A., Samolinski B., Nittner-Marszalska M.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 3

6

Polymorphisms in the genes encoding TGF-beta1, TNF-alpha, and IL-6 show association with type 1 diabetes mellitus in the Slovak population

72%

Javor J., Ferencik S., Bucova M., Stuchlikova M., Martinka E., Barak L., Strbova L., Grosse-Wilde H., Buc M.

Archivum Immunologiae et Therapiae Experimentalis

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2010

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tom 58

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nr 5

385-393

7

The angiotensin converting enzyme gene I/D polymorphism in Polish rowers

72%

Jastrzebski Z., Leonska-Duniec A., Kolbowicz M., Tomiak T.

Central European Journal of Sport Sciences and Medicine

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2014

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tom 05

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nr 1

Angiotensin converting enzyme gene (ACE) is the most frequently investigated genetic marker in the context of genetic conditioning of athletic predispositions. The product of the gene is a key component of the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), mainly responsible for the regulation of blood pressure. The main aim of the study was to determine the possible interaction between the ACE l/D polymorphism and endurance athlete status in a group of Polish rowers in comparison with sedentary individuals. 121 male Polish rowers, members of academic sports clubs, and 115 unrelated volunteers, were recruited for the study. The PCR amplification of the insertion (I) or deletion (D) fragment of the ACEgene was performed. Compared with control group, the frequency of the I allele differ significantly from that found in rowers (57.4% vs. 44.3%; P = 0.013) and the ACE genotype frequency amongst the whole cohort of rowers (30.6% II, 53.7% ID, 15.7% DD) was also different from expected values (control group 19.1% II, 50.4% ID, 30.4% DD; P=0.017). Our investigation confirms a positive association of the I allele of the ACE gene with endurance athlete status in a group of Polish rowers.

8

Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review

72%

Slebioda Z., Szponar E., Kowalska A.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 3

9

Vascular function and nitric oxide production in chronic social-stress-exposed rats with various family history of hypertension

72%

Bernatova I., Csizmadiova Z., Kopincova J., Puzserova Z.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 3

The study investigated the effect of chronic crowding stress on vascular function and nitric oxide (NO) production in rats with various family history of hypertension. Wistar (W), wBHR (offspring of W dams and spontaneously hypertensive sires), sBHR (offspring of spontaneously hypertensive dams and W sires) and spontaneously hypertensive rats (SHR) were used. Twelve-week-old males were divided into the control or crowded group for eight weeks. Basal blood pressure (BP, determined by tail-cuff plethysmography) of W, wBHR, sBHR and SHR rats was 112 ± 3, 129 ± 2, 135 ± 2 and 187 ± 3 mmHg, respectively. Crowding increased BP and reduced aortic NO synthase activity only in sBHR and SHR rats, without alterations in hypothalamic NO production. Acetylcholine-induced vasorelaxation of the femoral artery of stress-exposed rats was improved in W, unaltered in wBHR and sBHR and reduced in SHR. Crowding reduced serotonin-induced vasoconstriction in W and wBHR rats but had no effect in sBHR and SHR rats. In conclusion, the results suggest that crowded offspring of normotensive mothers were able to modify their vascular function in order to maintain BP at normal levels. On the other hand, offspring of hypertensive mothers were unable of effective adaptation of vascular function in stressful conditions resulting in gradual development of hypertension.

10

Is decreased renal uric acid excretion in familial hyperuricemia linked to 17q21 ?

72%

Grassler J., Parpart B., Kuhlisch E., Spitzenberger F., Kopprasch S., Schroder H. E.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

11

Simultaneous detection of malignant hyperthermia and genetic predisposition for improved litter size in pigs by multiplex PCR-RFLP

72%

Omelka R., Vasicek D., Martiniakova M., Bulla J., Bauerova M.

Folia Biologica

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2004

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tom 52

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nr 1-2

12

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients

58%

Groblewska M., Mroczko B., Gryko M., Kedra B., Szmitkowski M.

Folia Histochemica et Cytobiologica

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2010

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tom 48

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nr 4

13

Characteristic of morphological changes of the spine in selected mammal species

58%

Jundzill-Bogusiewicz P., Gruszczynska J., Shuvar I., Papis K.

Acta Scientiarum Polonorum. Zootechnica

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2021

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tom 20

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nr 3

14

Koprofagia - zaburzenia behawioralne czy genetyczny imprinting?

44%

Cichon R., Czyzyk R., Modrzyk J.

Weterynaria w Praktyce

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2020

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tom 17

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nr 04

Ograniczanie wyników

Cystic fibrosis is a risk factor for celiac disease

Genetic predisposition to breast and/or ovarian cancer – focus on the candidate BARD1 gene

Correction of the antebrachial deformity using circular external skeletal fixator in 7 dogs

Association between alpha-adducin gene polymorphism [Gly460Trp] and genetic predisposition to salt sensitivity: a meta-analysis

The impact of sex and age on the prevalence of clinically relevant sensitization and asymptomatic sensitization in the general population

Polymorphisms in the genes encoding TGF-beta1, TNF-alpha, and IL-6 show association with type 1 diabetes mellitus in the Slovak population

The angiotensin converting enzyme gene I/D polymorphism in Polish rowers

Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review

Vascular function and nitric oxide production in chronic social-stress-exposed rats with various family history of hypertension

Is decreased renal uric acid excretion in familial hyperuricemia linked to 17q21 ?

Simultaneous detection of malignant hyperthermia and genetic predisposition for improved litter size in pigs by multiplex PCR-RFLP

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients

Characteristic of morphological changes of the spine in selected mammal species

Koprofagia - zaburzenia behawioralne czy genetyczny imprinting?