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Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

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Vogt U., Falkiewicz B., Bielawski K., Bosse U., Schlotter C. M.

Acta Biochimica Polonica

2000

tom 47

nr 1

A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Bielawski K.

1 Bosse U.

1 Falkiewicz B.

1 Schlotter C. M.

1 Vogt U.

1 2000

Wyniki wyszukiwania

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay