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The effect of transcutaneous nerve stimulation (TENS) on gastric electrical activity

100%

Furgala A., Thor P. J., Kolasinska-Kloch W., Krygowska-Wajs A., Kopp B., Laskiewicz J.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 4,1

TENS became widely accepted method of treatment pain syndromes in clinical practice. Lately has been shown that its affects also gastrointestinal tract by releasing NANC neurotransmitter VIP. The aim of this study was to evaluate the effects of TENS on gastric myoelectric activities measured by electrogastrography (EGG). Eighteen healthy men (mean age 23 1.7) were included in the study. Healthy volunteers were divided on 3 groups each 6 persons: with normogastria occurring at 94.5 7% of recording time — group A, with predominant bradygastria (36.6 ± 14%) — group B and with tachygastria (33 14%) — group C. In fasted condition EGG (Synectics, Sweden) was recorded with skin electrodes. TENS 15 min was performed with use of Sinus 5 stimulator (6 Hz, 0.1ms duration, intensities 10 — 20mA, Zimmer, Germany). Stimulating electrodes were placed on non-dominant hand. Results: None of the subjects during TENS reported any side effects or symptoms, during the all studies. In group A in the fasting recordings, after TENS, an decrease of the normal values in the range 2 — 4cpm down to 78.5 ± 21% of recording time (p = 0.03) occurred. The dominant frequency in the bradygastric region increased up to 17.7 7% of the total recording. In group B TENS decreased bradygastria level from 36.6 14% to 20.6 15% (p = 0.02). TENS did not significantly affect tachygastria in group C. Amplitude of the EGG signal after TENS in group B and C increased by 40 and 150% respectively (p < 0.05). Significant decrease of the amplitude was observed in group A (13%). We conclude that TENS by activating centrally mediated somato-visceral reflexes affects gastric electrical activity. Our results suggest that TENS may be useful in treatment of the gastric dysrhythmia.

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The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication - an electrogastrographic study

86%

Budzynski A., Dobrzynski A., Lorens K., Konturek P. C., Thor P., Konturek S. J.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 2

Cholecystokinin (CCK) plays an important role in the regulation of postprandial gastric motor activity which was found to be abnormal in duodenal ulcer patients. This study was designed to compare the influence of CCK on gastric myoelectrical function in duodenal ulcer patients and healthy controls. Fifteen patients with active duodenal ulcer and Helicobacter pylori (H. pylori) infection and 15 healthy controls were included into this study. Electrogastrography (EGG) was performed before and 4 weeks after the eradication of H. pylori in ulcer patients and in healthy controls. We compared EGG parameters in the fasting and postprandial period and during intravenous infusion of caerulein, an analog of CCK with or without addition of loxiglumide, a specific CCK-1 receptor antagonist. The amplitude of fasting EGG in duodenal ulcer patients was similar to that in control subjects and was not affected by H. pylori eradication. In contrast, the amplitude of postprandial EGG was markedly increased in duodenal ulcer patients when compared to that in healthy controls and it was significantly reduced following the eradication of H. pylori. The blockade of CCK-1 receptors with loxiglumide in healthy controls or H. pylori eradicated ulcer patients significantly enhanced postprandial EGG amplitude almost to the level observed in the infected duodenal ulcer patients, but failed to affect this amplitude in ulcer patients. Exogenous caerulein, an analog of CCK, failed to affect EGG amplitude in duodenal ulcer patients with H. pylori infection, but it reduced significantly EGG amplitude in these patients after H. pylori eradication and in control subjects. This inhibitory effect of caerulein in H. pylori negative ulcer patients and healthy controls was abolished by the addition of loxiglumide. Ulcer patients showed significant dysrhythmia with tachygastria up to 20% of the recording time both under basal conditions and postprandially and H. pylori eradication was followed by a significant decrease in tachygastria to about 5%, the value being similar to that in healthy controls. We conclude that the amplitude and frequency of gastric myoelectrical activity are enhanced in duodenal ulcer patients and impaired in response to CCK but these changes can be normalized by successful H. pylori eradication.

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Sluggish gallbladder emptying and gastrointestinal transit after intake of common alcoholic beverages

72%

Kasicka-Jonderko A., Jonderko K., Gajek E., Piekielniak A., Zawislan R.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 1

4

Dysfunction of the autonomic nervous system activity is responsible for gastric myoelectric disturbances in the irritable bowel syndrome patients

72%

Mazur M., Furgala A., Jablonski K., Madroszkiewicz D., Ciecko-Michalska I., Bugajski A., Thor P. J.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 3

131-139

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Autonomic regulation of gastric myoelectrical activity in postmenopausal women supplemented with ovarian hormones

58%

Banach T., Thor P. J., Milewicz T., Krzysiek J.

Journal of Physiology and Pharmacology. Supplement

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2001

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tom 52

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nr 2

6

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Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspepsia

58%

Thor P., Lorens K., Tabor S., Herman R., Konturek J. W., Konturek S. J.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 3

Ograniczanie wyników

The effect of transcutaneous nerve stimulation (TENS) on gastric electrical activity

The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication - an electrogastrographic study

Sluggish gallbladder emptying and gastrointestinal transit after intake of common alcoholic beverages

Dysfunction of the autonomic nervous system activity is responsible for gastric myoelectric disturbances in the irritable bowel syndrome patients

Autonomic regulation of gastric myoelectrical activity in postmenopausal women supplemented with ovarian hormones

Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspepsia