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Fiber osteodystrophy (nutritional secondary hyperthyroidism) is an uncommon and poorly investigated disease of horses, connected with diet mistakes and secondary hormonal disturbances. The aim of this study was to asses selected biochemical parameters before and after the treatment of advanced forms of this illness. Horses from the control (healthy) and experimental groups were at the same age and originated from the same area. The affected horses were fed with fodder rich in phosphorus (oats). The horses of the control group were fed with corn mix, carrots, and sugar beets, and had free access to a saline lick. The clinical signs were big head symptoms, painfulness of cranial bones (especially the jaw bone), breathing problems, and joint pain in the extremities. P concentration in blood was statistically significantly lower, Ca and Mg concentrations were within the lowest physiological norms, and there was a significant increase in AST, AP and GGTP activity. After treatment, P concentration in blood increased statistically significantly, and hepatic indicators were slightly improved. The clinical symptoms remained unchanged.
The studies were carried out on 90 male guinea pigs ot which 75 were infected per os with a dose of ca. 5000 invasive eggs of Ascaris lumbricoides suis. At the 1st, 2nd, 4th, 7th and 20th day ot intection blood was taken from experimental and control animals. The activity of LDH and its liver traction (spectrophotometric method), GGTP (circle test method) was determined. The level of glucose (orthotoluidin methhod) and alpha amino nitrogen (ninhydrin method was determined. In the course of larval ascariasis an increase in the values of the studied parameters was noted, especially at the 4th and 7th day of infection. The changes in the activity of the studied enzymes evidence disturbances of the structure and function of the liver of infected animals. The increased level of glucose and alpha amino nitrogen is probably associated with a disturbance of basic energy metabolism of the host organism.
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