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  1. 4 Acta Scientiarum Polonorum. Administratio Locorum

  2. 2 Cellular and Molecular Biology Letters

  3. 1 Acta Biochimica Polonica

  4. 1 Acta Ichthyologica et Piscatoria

  5. 1 Acta Neurobiologiae Experimentalis

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  1. 2 Jaszczak A.

  2. 1 Abdullah H.

  3. 1 Broczek K. M.

  4. 1 Camejo D.

  5. 1 Chang M. S.

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  1. 1 2020

  2. 1 2018

  3. 1 2016

  4. 1 2015

  5. 3 2013

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1

The age-dependent induction of apoptosis-inducing factor [AIF] in the human semitendinosus skeletal muscle

100%
Park S. Y., Kim H. Y., Lee J. H., Yoon K. H., Chang M. S., Park S. K.
Cellular and Molecular Biology Letters
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2010
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tom 15
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nr 1
1-12
To assess the dependence on age of the expression of apoptosis regulatory proteins in the human semitendinosus muscle, we measured the expression levels of several apoptosis-related genes, including apoptosis-inducing factor (AIF), Bax, Bcl-2, caspase-3 and heat shock protein 70 (HSP70), using RT-PCR, immunohistochemistry and TUNEL assays. We found that the DNA fragmentation was proportional to the age of the tissues sample donors. The expression levels of AIF were significantly elevated (by 10 to 25%) in semitendinosus tissue samples from older individuals, but the Bax, Bcl-2, caspase-3 and HSP 70 levels remained almost constant. This data suggests that the morphological and functional changes observed in aged human semitendinosus muscle correlates with the apoptosis of muscle cells through the induction of AIF.
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

S-nitrosylation promotes functional and structural changes in the mitochondrial psPrxII F protein

100%
Camejo D., Lazaro J., Romero-Puertas M., Lazaro-Payo A., Sevilla F., Jimenez A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2013
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tom 94
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nr 2
3
Content available remote

Asthma, allergy, and respiratory symptoms in centenarians living in Poland

100%
Mossakowska M., Pawlinska-Chmara R., Broczek K. M.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 6
483-489
4

Landscape values and functional changes of suburban areas: a case study of Gottingen (Germany)

100%
Szucs L., Jaszczak A.
Acta Scientiarum Polonorum. Administratio Locorum
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2013
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tom 12
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nr 2
5

Ultrastructure of chloride cells in the starred sturgeon Acipenser stellatus Pallas and its functional changes during adaptation to sea water

100%
Semenova O. G., Krayushkina L. S., Ogorzalek A.
Zoologica Poloniae
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2000
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tom 45
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nr 1-4
6

Thermotolerance in erythrocytes - damage to proteins

100%
Rogozinska M., Koter M.
Cellular and Molecular Biology Letters
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2002
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tom 07
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nr Suppl.
7

Structural and functional changes of bovine carbonic anhydrase as a consequence of temperature

100%
Sarraf N. S., Saboury A. A., Ranjbar B., Moosavi-Movahedi A. A.
Acta Biochimica Polonica
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2004
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tom 51
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nr 3
The temperature dependence of the activity and structure of the enzyme carbonic anhydrase was studied. The Arrhenius plot shows a jump which is seen usually in proteins with more than one subunit or with one subunit but more than one domain. Since carbonic anhydrase has only one subunit with one domain, the fine conformational changes of the protein motifs could only be detected through circular dichroism polarimetry. It seems that the jump in Arrhenius plot is a result of some slight structural changes in the secondary and tertiary structures of the enzyme.
8

Age-associated functional morphology of thyroid and its impact on the expression of vimentin, cytokeratins and VEGF. The role of nigella in refinement

80%
Mohamed Zaki S., Mohamed E. A., Fattah S. A., Abdullah H., Kaszubowska L.
Folia Histochemica et Cytobiologica
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2018
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tom 56
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nr 3
9

Anatomical and functional effects of the parasitic copepod Lernaeocera branchialis (L.) on Pollachius pollachius (L.) (Pisces: Gadidae)

80%
Rokicki J.
Acta Ichthyologica et Piscatoria
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1988
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tom 18
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nr 2
10

Adjuvant stem cell-based therapy in acute retinal injury after sodium iodate administration in mice: Morphological and functional study

80%
Machalinska A., Roginska D., Pius E., Stepniewski J., Kawa M., Jozkowicz A., Dulak J., Machalinski B.
Acta Neurobiologiae Experimentalis
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2013
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tom 73
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nr 1
Ophthalmic diseases, especially retinal degeneration belong to prominent causes of disability in developed countries. Thus, special attention has been focused on research aimed on establishing new protocols of efficient stem cell (SC)-based therapy of these disorders. The aim of this study was to determine and optimize a new strategy of SC-based therapy of selectively damaged retina after sodium iodate (NaIO3) administration in C57BL/6J mice. First, we sought to assess the regenerative mechanisms triggered after acute chemical injury of retinal pigment epithelium and neurosensory retina induced by NaIO3, in mice. The intravenous injection of NaIO3 provides a useful model for the study of retinal degeneration since it mimics some retinal degenerative diseases in humans, e.g., gyrate atrophy, retinitis pigmentosa or age-related macular degeneration. We evaluated the kinetics of morphological and functional changes within mice retinas injured with NaIO3 via: (1) morphological study; (2) evaluation of expression of selected neurotrophins (NTs) in injured retina; (3) visualization of proliferating and apoptotic cells; (4) electrophysiology. Our findings revealed that massive destruction of the tissue was associated with irreversible retinal dysfunction, whereas moderate retinal injury triggered regenerative mechanisms that restore bioelectrical function of the damaged retina. Next, we performed intravitreal transplantation of murine GFP+Lin- cells on the 1st day since NaIO3 administration. We analyzed number and localization of intravitreally injected GFP+Lin- cells within recipients’ retinas as well as the retinal functional changes (electroretinography). By employing stem/progenitor cell-based therapy we achieved noticeable improvement in retinal function, particularly in the case of only partial primary destruction of retinal tissue. Furthermore we investigated the neuroprotective effects of different NTs, administered intravitreally via genetically modified SCs into degenerating retinal tissue. The synthetic viral vectors based on lentivirus (LVs) backbone was used to deliver NT genes into mesenchymal stem cells isolated from bone marrow. Then, we conducted multipart analysis based on functional tests, e.g., electroretinography as well as histological, immunohistochemical, morphometric, and molecular biology studies. We found that specific, exogenously administered NTs, such as NT4/5 could effectively stimulate photoreceptor survival in the degenerating retinas. Our findings reveal that the proposed therapeutic strategy could be recommended as adjuvant therapy supporting endogenous regeneration of acute retinal damage. However, further more extensive studies are needed before the introduction of this kind of therapy into patients.
11

The changes of forms and functions of rural private households in socio-economic transition

80%
Eglite A.
Prace Naukowe. Szkoła Główna Gospodarstwa Wiejskiego. Wydział Ekonomiczno-Rolniczy. Katedra Polityki Agrarnej i Marketingu
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2004
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nr 33
12

The role and regulation of mTOR in T-lymphocyte function

80%
O'Brien T. F., Zhong X.-P.
Archivum Immunologiae et Therapiae Experimentalis
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2012
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tom 60
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nr 3
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The role of rural areas in the creation of eco-resilient suburbs of Warsaw

80%
Zdunek-Wielgolaska J., Grabowska A.
Acta Scientiarum Polonorum. Architectura
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2020
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tom 19
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nr 3
14
Content available remote

Pathophysiology of ageing

80%
Knapowski J., Wieczorkowska-Tobis K., Witowski J.
Journal of Physiology and Pharmacology
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2002
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tom 53
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nr 2
Ageing is characterized by a gradual decline in organ functional reserves which reduces the ability to maintain homeostasis under conditions of stress. Introduction of cell culture and molecular biology techniques has provided new experimental tools for the analysis of ageing at the molecular level. During ageing progressive degeneration of cells and loss of regenerative capacity are enhanced and with time the alterations caused by them ultimately lead to death. In this paper the current knowledge of the mechanisms of ageing is summarized.
15

Wpływ funduszy europejskich na zmiany przestrzenno-funkcjonalne na przykładzie miasta Ostródy

71%
Szarek P. K.
Acta Scientiarum Polonorum. Administratio Locorum
|
2016
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tom 15
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nr 3
16

Przemiany struktury funkcjonalno-przestrzennej Pomorza w ujęciu wielofunkcyjnego i zrównoważonego rozwoju

71%
Czapiewska G.
Acta Scientiarum Polonorum. Administratio Locorum
|
2012
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tom 11
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nr 2
17

Rozważania nad wpływem monotonicznej, niskiej dawki zearalenonu na wybrane tkanki układu pokarmowego ssaków monogastrycznych

61%
Gajecki M., Gajecka M., Zielonka L.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
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2015
|
tom 10
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nr 2
18

Zmiany funkcjonalno-przestrzenne wybranych założeń dworsko-parkowych regionu Kociewia

61%
Jaszczak A., Mlynarczyk K., Woznicka A.
Acta Scientiarum Polonorum. Administratio Locorum
|
2010
|
tom 09
|
nr 3
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