Wyniki wyszukiwania

1

Is there a rescue - scheme for the chemotherapy with gemcitabine ?

100%

Wosegien F., Graeve T.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

2

The knowledge of food science female students of diet supplementation with folic acid

86%

Czarnowska M., Nowotka A., Jakubowska D., Gujska E., Michalak J.

Towaroznawcze Problemy Jakości. Polskie Towarzystwo Towaroznawcze

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2015

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nr 4

3

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Intakes of folic acid from dietary supplements and fortified products in students

86%

Sicinska E., Bojarska K.

Roczniki Państwowego Zakładu Higieny

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2013

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tom 64

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nr 1

Background. A great variety of dietary supplements and fortified products, containing folic acid, are widely available to satisfy the market demand for supplementing the diet with this vitamin. Objective. To assess folic acid intake from dietary supplements and fortified products in students. Materials and methods. The study was performed between October 2010-April 2011 on 314 university students aged 19- 34 years, excluding pregnant or lactating women. Self-administered questionnaire was used to collect information about health, lifestyle and use of dietary supplements during previous month (frequency and doses) and frequency and portion of the fortified products consumed. Results. Diets were supplemented by folic acid by almost 13% of respondents; the average intake was 148 ± 99.7 μg/person/ day, (range 10-400 μg). Products fortified with this vitamin were used by 89% students with an average intake of folic acid 83.7 ± 101 μg/person/day, (range 0.3-660 μg); about a quarter of these subjects were however unaware that they were consuming fortified products. Both product types were used together by 11% students. Among these subjects the average folic acid intake was the highest (233 ± 151 μg/person/day, range 12.3–678 μg); with 66% originating from supplements and 34% from fortified products. There were no instances of folic acid being consumed above the tolerable upper intake level (UL), of 1000 μg/day. Conclusions. It is necessary to warn the public that overconsumption of folic acid, (through dietary supplements, enriched food), may be hazardous to health, since many people combine such multiple products.

4

Birth defects surveillance in Ukraine: a process

86%

Wertelecki W.

Journal of Applied Genetics

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2006

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tom 47

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nr 2

Birth defects (BD) surveillance using international standards was introduced in Ukraine by a network of five BD centers located in northwestern, central and southern regions. BD centers provide resources to access current and comprehensive information and to nurture partnerships with physicians, administrators, parental support groups, educators, and humanitarian assistance organizations. One outcome was the vigorous and popular website International BD Information Systems (IBIS). The network is now incorporated as OMNI-Net Ukraine. The program has documented high prevalence rates of neural tube defects (NTD); fetal alcohol effects (FAE); and idiopathic developmental retardation among orphans that prompted prevention and amelioration initiatives. Further program objectives include: universal folic acid flour fortification, as recommended by the Ukrainian Academy of Medicine; continued research on methods to reduce FAE in collaboration with partners from California; opening other early infant stimulation centers funded by local authorities, modeled on those in Rivne and Lutsk; and linking BD prevention with bioethical considerations, which is a topic of interest in Ukraine in part enhanced by the effects of Chornobyl.

5

Factors affecting radical-scavenging activity of folic acid and biopterin

86%

Gliszczynska-Swiglo A., Szymusiak H.

Acta Toxicologica

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2007

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tom 15

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nr 1

6

Some difficulties in research into cell motile activity under isotropic conditions

86%

Waligorska A., Wianecka-Skoczen M., Nowak P., Korohoda W.

Folia Biologica

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2007

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tom 55

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nr 1-2

7

Concentration of folic acid and natural folates in fruit, fruit-vegetable juices and nectars fortified with folic acid

72%

Gujska E., Czarnowska M., Michalak J.

Towaroznawcze Problemy Jakości. Polskie Towarzystwo Towaroznawcze

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2014

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nr 1

8

Different bone sensitivity to malformations induced by procarbazine in fetal rats

72%

Weingartner J., Proff P., Fanghanel J., Kundt G., Gedrange T., Kubein-Meesenburg D., Gredes T.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 5

17-25

9

Reversible inhibition of movement in the amoebae Dictyostelium discoideum and its effect on chemoattractant recognition

72%

Waligorska A., Wianecka-Skoczen M., Korohoda W.

Folia Biologica

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2008

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tom 56

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nr 3-4

123-131

10

Knowledge among young people about folic acid and its importance during pregnancy: a survey in the Federal State of Saxony-Anhalt [Germany]

72%

Potzsch S., Hoyer-Schuschke J., Seelig M., Steinbicker V.

Journal of Applied Genetics

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2006

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tom 47

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nr 2

Periconceptional folic acid supplementation is recommended to prevent congenital malformations, mainly neural tube defects, but only 7% of pregnant women in Saxony-Anhalt (Germany) take folic acid at least 4 weeks before conception and in the first 3 months of pregnancy. From March to June 2004, we sent standardized questionnaires about folic acid and its importance during pregnancy to 33 schools in the Federal State of Saxony-Anhalt. A total of 4332 young people aged 1521 years completed the questionnaire, of which 2632 were girls (61%) and 1685 were boys (39%). The majority of them (61%) had heard about folic acid, but only 5% knew that it is a vitamin and 0.7% were aware of the physiological functions of folic acid. Only 22% of the young people answered that folic acid should be taken before and during pregnancy, whereas almost all respondents knew other precautions during pregnancy, e.g. “no smoking” and “no alcohol”. Our survey shows that the level of awareness of the importance of folic acid at schools is very low. We suggest that the problem of folic acid should be included in the curricula of biology classes at schools to spread the knowledge of this subject among young people.

11

Effect of various amounts of folic acid added to rat food on food intake and some parameters of carbohydrate metabolism

72%

Prusiewicz-Witaszek U., Maciejewska M.

Archivum Veterinarium Polonicum

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1994

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tom 34

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nr 3-4

12

The influence of synergistic action of folic acid, beta-carotene and vitamin A on embryo mortality in primiparous and multiparous sows

72%

Pres J., Orda J., Wiliczkiewicz A., Fuchs B.

Polish Journal of Veterinary Sciences

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1999

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tom 02

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nr 2

The experiments were carried out to estimate the possibilities of stimulation of the fecundity of sows by administering Vitamin A, ß-carotene and folic acid as basic feed supplement. It has been expected that the synthetic ß-carotene and Vitamin A will increase inhibits embryo mortality. In the first experiment animals were primiparous and in the second multiparous sows. All animals were slaughtered on 30th day of gestation. The reproductive tracts were recovered and dead, partially resorbed and viable embryos were counted. Also weight of ovaries and number of corpora lutea evaluated and on this basis were estimated ovulation rate. In the blood samples concentration of folates, A1AT and AspAT activity, Ca, P and urea quantity were estimated. Addition 5 mg/kg folic acid to basal diet for primiparous sows decrease number of dead fetuses and simultaneously administering 200 mg ß-carotene/animal/day significantly increase number of presumably living fetuses (from 8.3 to 10.8). Addition 60000 IU of Vitamin A haven't had significant influence for the number of dead or living fetuses, while increased level of it was noted in liver. Under the synthetic ß-carotene treatment multiparous sows, the higher number of viable fetuses, number of corpora lutea and weight of ovaries than in the control group were also observed. Extra addition of folic acid decreases significantly (P < 0.05) number of dead fetuses. Similar effects are obtained by replacing ß-carotene+folic acid with Vitamin A+folic acid for multiparous sows. The obtained result indicates that the addition of the synthetic ß-carotene to the diet for sows before and after mating increases ovulation rate. The simultaneous folic acid supplement from the time of mating inhibits embryo mortality.

13

The impact of prenatal diagnosis on neural tube defect [NTD] pregnancy versus birth incidence in British Columbia

72%

Van A. M. I., Boyle E., Thiessen P., McFadden D., Cochrane D., Chambers G. K., Langlois S., Stathers P., Irwin B., Cairns E., MacLeod P., Delisle M. F., Uh S. H.

Journal of Applied Genetics

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2006

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tom 47

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nr 2

The birth incidence of neural tube defect (NTD) cases in British Columbia (B.C.), and elsewhere in North America, is reported to be declining. This decline is being attributed to folic acid (FA) supplementation and food fortification, but 2nd trimester prenatal screening of pregnancies for NTDs and other congenital anomalies has increased during this timeframe, as well. This descriptive, population-based study evaluates the impact of prenatal screening of NTD-affected pregnancies on (1) pregnancy outcome and (2) reporting of NTD births to the provincial Health Status Registry (B.C.H.S.R.); and it assesses (3) the use of periconceptional FA supplementation. NTD cases were ascertained from medical records of health centres providing care to families with NTD-affected pregnancies and newborns; and from NTD cases reported to the B.C.H.S.R. In 1997-1999, the B.C.H.S.R. published a NTD incidence of 0.77/1000. In this study, 151 NTD-affected pregnancies were identified, with an incidence of 1.16/1000. Partial Reporting of induced abortions in a NTD incidence 45.5% low than the actual incidence. Medical records were available for review on 144/151 pregnancies. Prenatal screening identified 86.1% (124/144) of NTD-affected pregnancies, with 72.6% (90/124) resulting in pregnancy termination, and 27.4% (34/124) continuing to term. Use of FA supplementation in the periconceptional period was recorded in 36.4% of pregnancies (39/107). Thus in B.C. the decline in the NTD incidence is due predominantly to pregnancy terminations following prenatal diagnosis, which reduces the NTD incidence by 60%, from 1.16/1000 to 0.47/1000. Continued efforts for primary and the option of secondary prevention of NTDs are recommended in order to improve newborn health in B.C. and elsewhere. These interventions need to be monitored, however, for optimal health care planning.

14

Effects of stage of lactation on protein metabolism in dairy cows

72%

Lapierre H., Girard C. L., Matte J. J., Lobley G. E.

Journal of Animal and Feed Sciences

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2005

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tom 14

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nr 1

15

Folic acid supplementation practice in Europe - plenary lecture

72%

Pietruszka B., Brzozowska A.

Polish Journal of Food and Nutrition Sciences

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2006

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tom 15/56

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nr Spec.Issue 2

There are sparse data on supplementation practice related to folic acid (FAS). The prevalence of FAS usage in different European countries/areas varied from 10% to 43% among women before pregnancy, from 9% to 80% during pregnancy and from 0% to 53% in other population groups. With respect to public health, the results of this study indicate that there is a need to consider which strategy of increasing folates intake could be effective in demographic, cultural, economic etc. situation in each country. Because of the increased intake of folic acid there is a need for monitoring supplements and fortified food as the sources of this nutrient to determine exposure at the individual and population levels as well as some measurable health outcomes. It was found that a high intake of folic acid resulted in an increased level of this unmetabolized form in plasma, hence the use of [6S-]-5-methyltetrahydrofolic acid, the natural circulating folate form, should be considered as a supplement and fortificant.

16

Folic acid restores the motility of Dictyostelium discoideum inhibited by triethyllead

72%

Sroka J., Madeja Z., Michalik M., Przestalski S., Korohoda W.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

17

Niedokrwistosc - podstepny wrog

58%

Krzyzanowska M.

Żywność, Żywienie, Życie. Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

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2002

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nr 3

33-35

18

Influence of dendrimers on red blood cells

58%

Ziemba B., Matuszko G., Bryszewska M., Klajnert B.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 1

The emerging fields of tissue engineering and biomaterials have begun to provide potential treatment options for liver failure. The goal of the present study is to investigate the ability of a poly L-lactic acid (PLLA) nanofiber scaffold to support and enhance hepatic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs). A scaffold composed of poly L-lactic acid and collagen was fabricated by the electrospinning technique. After characterizing isolated hMSCs, they were seeded onto PLLA nanofiber scaffolds and induced to differentiate into a hepatocyte lineage. The mRNA levels and protein expression of several important hepatic genes were determined using RT-PCR, immunocytochemistry and ELISA. Flow cytometry revealed that the isolated bone marrow-derived stem cells were positive for hMSC-specific markers CD73, CD44, CD105 and CD166 and negative for hematopoietic markers CD34 and CD45. The differentiation of these stem cells into adipocytes and osteoblasts demonstrated their multipotency. Scanning electron microscopy showed adherence of cells in the nanofiber scaffold during differentiation towards hepatocytes. Our results showed that expression levels of liver-specific markers such as albumin, α-fetoprotein, and cytokeratins 8 and 18 were higher in differentiated cells on the nanofibers than when cultured on plates. Importantly, liver functioning serum proteins, albumin and α-1 antitrypsin were secreted into the culture medium at higher levels by the differentiated cells on the nanofibers than on the plates, demonstrating that our nanofibrous scaffolds promoted and enhanced hepatic differentiation under our culture conditions. Our results show that the engineered PLLA nanofibrous scaffold is a conducive matrix for the differentiation of MSCs into functional hepatocyte-like cells. This represents the first step for the use of this nanofibrous scaffold for culture and differentiation of stem cells that may be employed for tissue engineering and cell-based therapy applications.

19

Homocysteine level in urine of autistic and healthy children

58%

Kaluzna-Czaplinska J., Michalska M., Rynkowski J.

Acta Biochimica Polonica

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2011

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tom 58

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nr 1

Homocysteine is an amino acid which plays several important roles in human physiology and is an important biomarker for possible deficiencies of various vitamins (vitamin B6 and B12, folic acid). In this work GC-MS method was used to determine the levels of homocysteine in the urine of autistic and healthy children. The levels of homocysteine in urine samples from 34 autistic and 21 healthy children were 2.36 ± 1.24 and 0.76 ± 0.31 (mmol∙mol-1 creatinine), respectively. The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B6 and B12 in nutrition of these children. The results of this work were taken into consideration in the nutrition of autistic children treated in the Navicula Centre of Diagnosis and Therapy of Autism in Łódź (Poland).

20

Wpływ kwasu askorbinowego na wyniki oznaczeń „kwasu foliowego” w produktach spożywczych

58%

Suckewer A.

Roczniki Państwowego Zakładu Higieny

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1970

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tom 21

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nr 1

Ograniczanie wyników

Is there a rescue - scheme for the chemotherapy with gemcitabine ?

The knowledge of food science female students of diet supplementation with folic acid

Intakes of folic acid from dietary supplements and fortified products in students

Birth defects surveillance in Ukraine: a process

Factors affecting radical-scavenging activity of folic acid and biopterin

Some difficulties in research into cell motile activity under isotropic conditions

Concentration of folic acid and natural folates in fruit, fruit-vegetable juices and nectars fortified with folic acid

Different bone sensitivity to malformations induced by procarbazine in fetal rats

Reversible inhibition of movement in the amoebae Dictyostelium discoideum and its effect on chemoattractant recognition

Knowledge among young people about folic acid and its importance during pregnancy: a survey in the Federal State of Saxony-Anhalt [Germany]

Effect of various amounts of folic acid added to rat food on food intake and some parameters of carbohydrate metabolism

The influence of synergistic action of folic acid, beta-carotene and vitamin A on embryo mortality in primiparous and multiparous sows