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Fibrin D-dimer impairs the accumulation and anticoagulant properties of heparan sulphate and stimulates secretion of plasminogen activator inhibitor-1 by rabbit coronary endothelial cells

100%

Yevdokimova N. Y., Veselovska L. D., Gogolinska G. K., Buchanevich O. M., Kosyakova G. V., Gritsenko P. G., Lugovskoj E. V., Komisarenko S. V.

Acta Biochimica Polonica

2003

tom 50

nr 1

Fibrin split product D-dimer (DD) is most probably involved in the development of vascular disorders. At 1.5 uM concentration DD inhibited the incorporation of D-[1-3H]glucosamine hydrochloride and [2-14C]acetate • Na into pericellular heparan sulphate (HS) of rabbit coronary endothelial cells without affecting other groups of glycosaminoglycans (GAGs). At the same time, DD reduced HS ability to bind antithrombin (AT) and suppressed NO production. The effect of DD on pericellular GAGs was similar to that of Nω-methyl-L-arginine, the competitive inhibitor of endothelial NO synthase (eNOS). L-Ascorbic acid, eNOS activator, increased the level of endogenous NO in the DD-treated cells, and restored HS accumulation and antithrombin binding. It is suggested that DD influence on endothelial HS may be mediated by NO production. Another effect of DD, namely, stimulation of plasminogen activator inhibitor-1 (PAI-1) secretion did not depend on the NO level. The decreased HS content, reduced anticoagulant properties of HS, and increased PAI-1 secretion disorganized the endothelial matrix, and promoted fibrin formation and vascular damage. This points to DD as an important factor in the development of vascular disorders.

Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid

84%

Wade D., Silveira A., Rollins-Smith L., Bergman T., Silberring J., Lankinen H.

Acta Biochimica Polonica

2001

tom 48

nr 4

Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthesized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biological activities of CATA.

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Thrombolytic activity of beta-adrenolytic drug, sotalol

59%

Korbut R., Swies J., Marcinkiewicz E., Gryglewski R. J.

Journal of Physiology and Pharmacology

1998

tom 49

nr 1

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

1 Bergman T.

1 Buchanevich O. M.

1 Gogolinska G. K.

1 Gritsenko P. G.

1 Gryglewski R. J.

1 Komisarenko S. V.

1 Korbut R.

1 Kosyakova G. V.

1 Lankinen H.

1 Lugovskoj E. V.

1 Marcinkiewicz E.

1 Rollins-Smith L.

1 Silberring J.

1 Silveira A.

1 Swies J.

1 Veselovska L. D.

1 Wade D.

1 Yevdokimova N. Y.

1 2003

1 2001

1 1998

Wyniki wyszukiwania

Fibrin D-dimer impairs the accumulation and anticoagulant properties of heparan sulphate and stimulates secretion of plasminogen activator inhibitor-1 by rabbit coronary endothelial cells

Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid

Thrombolytic activity of beta-adrenolytic drug, sotalol