Wyniki wyszukiwania

1

Thrombin activatable fibrinolysis inhibitor [TAFI] in cord blood

100%

Uszynski W., Uszynski M., Zekanowska E., Goralczyk K.

Folia Histochemica et Cytobiologica

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2007

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tom 45

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nr 1

2

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Effect of fibrinogen degradation products on various stages of the fibrinolytic process

88%

Yatsenko T., Rybachuk V. N., Kharchenko S. M., Grinenko T. V., Yusova E. I.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 1

Over-activation of the fibrinolytic system may result in proteolytic destruction of fibrinogen. However, the effect of the degradation products formed during fibrinogenolysis on fibrinolytic process and plasminogen/plasmin properties remains unclear. To investigate this effect and its mechanism, the ability of fibrinogen fragments E and D to act on plasminogen and tPA binding, proenzyme activation, fibrin clot lysis and plasmin inhibition by plasma α2-antiplasmin, were studied. It was found that early product fragment EE binds to plasminogen and tissue-type plasminogen activator and enhances plasminogen conversion into plasmin. C-terminal lysine residues of all 3 chains pair and 16 or 23 amino acid residues of Aα- chain are essential for this process. C-terminal lysines of fragment E Aα- and γ-chains and lysine-binding site of tPA kringle 2 are responsible for the interaction between these proteins. Binding of fragment E to plasminogen is provided by N-terminal Aα1–19 and C-terminal Bβ120–122 regions. Late plasmic fibrinogen degradation product fragment EL loses the ability to potentiate plasmin generation but can bind proenzyme and its activator. Fragment D has no binding properties towards plasminogen and tPA. None of fibrinogen fragments protects plasmin from α2-antiplasmin inhibition. It is concluded that at over-activation of the fibrinolytic system and subsequent fibrinogenolysis, the products of fibrinogen degradation, can bind plasminogen and tPA and potentiate generation of plasmin, which will be neutralized under the normal level of the plasmin inhibitor.

3

Pericardium: structure and function in health and disease

75%

Jaworska-Wilczynska M., Trzaskoma P., Szczepankiewicz A. A., Hryniewiecki T.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 3

4

Haemostatic factors and intraluminal thrombus thickness in abdominal aortic aneurysm. Is secondary fibrinolysis relevant?

63%

Siennicka A., Drozdzynska M., Chelstowski K., Cnotliwy M., Jastrzebska M.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 3

5

Effect of the BVD-MD virus on coagulation and fibrinolytic systems in dairy cows

63%

Radwinska J.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 3

The experiment was performed on 30 cows, including 10 animals infected with the BVD-MD virus. The following parameters were determined: prothrombin time, thrombin time, activated partial thromboplastin time, fibrinogen and D-dimer concentrations, antithrombin III activity, and blood platelet counts. The obtained results indicated that the BVD-MD virus lowered blood platelet counts and led to dysfunctions in plasma coagulation and fibrinolytic systems. The observed changes in the examined haemostatic indicators suggest that BVD-MD infections could lead to the development of disseminated intravascular coagulopathy that has adverse consequences for the animals' health.

6

Antithrombotic medications and their impact on fibrin clot structure and function

63%

Undas A., Zabczyk M.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 4

7

Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats

63%

Gromotowicz-Poplawska A., Nazarko-Sadowska J., Chabielska E.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 3

8

N-methylnicotinamide inhibits arterial thrombosis in hypertensive rats

63%

Mogielnicki A., Kramkowski K., Pietrzak L., Buczko W.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 3

There are few findings indicating that nicotinamide may potentially influence intravascular thrombosis. Interestingly, N-methylnicotinamide, one of the metabolites of nicotinamide - could be more potent than its parent compound. In the present study we have investigated the influence of N-methylnicotinamide on arterial thrombosis in normotensive and renovascular hypertensive rats. The contribution of platelets, coagulation and fibrinolytic systems in the mode of N-methylnicotinamide action was also determined. Furthermore, we examined the role of nitric oxide/prostacyclin in the mechanisms of N-methylnicotinamide action. N-methylnicotinamide, but not nicotinamide, administered intravenously into renovascular hypertensive rats developing electrically induced arterial thrombosis caused dose-dependent decrease of thrombus weight, collagen-induced platelet aggregation and plasma antigen/activity of plasminogen activator inhibitor - 1, without changing of occlusion time, routine coagulation parameters and plasma activity of tissue plasminogen activator. Indomethacin - an inhibitor of prostacyclin synthesis, completely abolished the antithrombotic and antiplatelet effect of N-methylnicotinamide, and the plasma level of 6-keto-PGF1alpha, prostacyclin metabolite, increased simultaneously with the inhibition of thrombus formation. Our study shows that N-methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. The antithrombotic effect of N-methylnicotinamide is accompanied by platelet inhibition and enhanced fibrinolysis, due to the decrease production of plasminogen activator inhibitor - 1.

9

The effect of denatured alcohol on hemostatic system

63%

Dabrowski L., Gacko M., Samson J., Tomasiak M.

Acta Poloniae Toxicologica

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2001

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tom 09

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nr 2

10

Effects of anaerobic exercise in the morning and evening sessions on some coagulation factors in non-athletes female students of Islamic Azad University of Sanandaj

51%

Tabatabai E. F., Hematfar A., Saeidian S.

International Letters of Natural Sciences

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2014

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tom 05

The purpose of the present research is compare the effects of coagulation factors in non-athletes gilrs after exhaustive anaerobic activity sessions in the morning and evening. Present study was semi-emprical that was done on 12 non-athlete female students in range of 18-24 years. Exercise protocol was RAST test, that in which each person passed amain 35 meters of distance for 6 times and rest 10 seconds between each stage. Blood sampling was performed Once in the morning (8 am) and a later week in evening (5 pm) in two stages (before and after). Datas were analyzed with Kolmogorov Smirnov test, Levine's test and two-way ANOVA level (p < 0/05 ). The results showed that there was not significative difference between the effects of an anaerobic activity in the morning and in the evening on hematocrit, platelet, partial time Thromboplastin (PTT), Prothrombin time (PT) and fibrinogen in non-athletic subjects. Findings showed that training for normal persons, non-athletes and patients, especially patients with clotting problems, and cardiovascular disease will be suggeste, each activity to be act with caution at morning and during the day.

11

Effects of anaerobic exercise on some coagulation factors in non-athletes female students of islamic Azad University of Sanandaj

51%

Foroughi M., Tabatabai E. F.

International Letters of Natural Sciences

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2015

|

tom 39

The purpose of the present research is compare the effects of coagulation factors in nonathletes gilrs after exhaustive anaerobic activity .Present study was semi-emprical that was done on 12 non-athlete female students in range of 18-24 years. Exercise protocol was RAST test, that in which each person passed amain 35 meters of distance for 6 times and rest 10 seconds between each stage.Blood sampling was performed in two stages (before and after).Datas were analyzed with Kolmogorov Smirnov test, Levine's test and two-way ANOVA level (p < 0/05 ). The results showed that anaerobic exercise had a significant influence on partial time Thromboplastin (PTT), and fibrinogen in non-athletic subjects.But there was not significative difference on Prothrombin time (PT), platelet and hematocrit.Findings suggested that a meeting of anaerobic exercise on blood coagulation factor, effectiveness and changes in some of the invoices for training program Drafradghyrfal is important.

12

Platelets in fibrinolytic system

51%

Korbut R., Gryglewski R. J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 4

13

The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade

51%

Buczko W., Matys T., Kucharewicz I., Chabielska E.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 4

14

The effect of nitric oxide donors on the release of plasminogen activator inhibitor [PAI] from rabbit platelets in vitro

51%

Korbut R., Marcinkiewicz E., Cieslik K., Gryglewski R. J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 1

Ograniczanie wyników

Thrombin activatable fibrinolysis inhibitor [TAFI] in cord blood

Effect of fibrinogen degradation products on various stages of the fibrinolytic process

Pericardium: structure and function in health and disease

Haemostatic factors and intraluminal thrombus thickness in abdominal aortic aneurysm. Is secondary fibrinolysis relevant?

Effect of the BVD-MD virus on coagulation and fibrinolytic systems in dairy cows

Antithrombotic medications and their impact on fibrin clot structure and function

Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats

N-methylnicotinamide inhibits arterial thrombosis in hypertensive rats

The effect of denatured alcohol on hemostatic system

Effects of anaerobic exercise in the morning and evening sessions on some coagulation factors in non-athletes female students of Islamic Azad University of Sanandaj

Effects of anaerobic exercise on some coagulation factors in non-athletes female students of islamic Azad University of Sanandaj

Platelets in fibrinolytic system

The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade

The effect of nitric oxide donors on the release of plasminogen activator inhibitor [PAI] from rabbit platelets in vitro