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High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)

100%

Ilic S., Drmic D., Zarkovic K., Kolenc D., Coric M., Brcic L., Klicek R., Radic B., Sever M., Djuzel V., Ivica M., Boban Blagaic A., Zoricic Z., Anic T., Zoricic I., Djidic S., Romic Z., Seiwerth S., Sikiric P.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 2

We focused on stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, an anti-ulcer peptide efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported) because of its hepatoprotective effects. We investigate a particular aspect of the sudden onset of encephalopathy with extreme paracetamol overdose (5 g/kg intraperitoneally) so far not reported: rapidly induced progressive hepatic encephalopathy with generalized convulsions in rats. BPC 157 therapy (10 µg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (µg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically). At 25 min post-paracetamol increased ALT, AST and ammonium serum values precede liver lesion while in several brain areas, significant damage became apparent, accompanied by generalized convulsions. Through the next 5 hour seizure period and thereafter, the brain damage, liver damage enzyme values and hyperammonemia increased, particularly throughout the 3-24 h post-paracetamol period. BPC 157 demonstrated clinical (no convulsions (prophylactic application) or convulsions rapidly disappeared (therapeutic effect within 25 min)), microscopical (markedly less liver and brain lesions) and biochemical (enzyme and ammonium serum levels decreased) counteraction. Both, the prophylactic and therapeutic benefits (intraperitoneally and intragastrically) clearly imply BPC 157 (µg-ng range) as a highly effective paracetamol antidote even against highly advanced damaging processes induced by an extreme paracetamol over-dose.

2

Rearing and fattening performance of variously fed crossbreeds of Muscovy drakes and Pekin-type ducks

100%

Mazanowski A., Bernacki Z.

Roczniki Naukowe Zootechniki

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2000

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tom 27

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nr 4

3

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Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver

80%

Tharwat M.

Polish Journal of Veterinary Sciences

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2012

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tom 15

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nr 1

The aim of the present study was to determine whether ultrasonographic evaluation of the hepatic parenchyma could be used as a diagnostic and prognostic approach in cows and buffaloes with hepatic lipidosis. For this purpose, cows (n=16) and buffaloes (n=10) with fatty infiltration of the liver were examined by ultrasonography. Treated cows and buffaloes were monitored for hepatic changes ultrasonographically, biochemically and histologically. Clinical findings were non-specific and included anorexia, recumbency, muzzle necrosis, and icteric mucosal membranes. Laboratory data revealed neutrophilia, hyper γ-globulinemia, elevated activities of aspartate aminotransferase, γ-glutamyl transpeptidase, creatine kinase and lactate dehydrogenase, and high concentrations of insulin, total bilirubin, non-esterified fatty acids and β-hydroxyl butyric acid. Laboratory results 7, and 21 days after treatment showed progressive improvement in the chemistry profile. On admission, ultrasonographic examination of the hepatic parenchyma in cows and buffaloes revealed either increased or decreased hepatic echogenicity; histologic examination revealed marked fatty infiltration of the hepatocytes. One week after treatment, the hepatic parenchyma was visualized easily, liver boundaries were clearly imaged, and histologic examination of hepatic specimen showed a moderate degree of fatty infiltration. Three weeks after treatment, the hepatic parenchyma was almost similar to normal, the hepatic and portal blood vessels could be easily imaged, and the histologic picture had greatly improved where the liver resembled the normal organ. Six cows and seven buffaloes made a full recovery while the remaining ten cows and three buffaloes were slaughtered and thoroughly examined postmortem. Ultrasonography showed a good correlation with histologic and laboratory findings.

4

Zastosowanie rozdrobnionej i natluszczonej kukurydzy w tuczu gesi i kaczek na stluszczone watroby

80%

Niewiarowicz A., Baszczynski J.

Biuletyn Informacyjny Drobiarstwa

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1992

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tom 30

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nr 5

5-10

5

Is fatty liver always benign and should not consequently be treated?

80%

Fierbinteanu-Braticevici C., Negreanu L., Tarantino G.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 1

6

Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats

71%

Ilic S., Brcic I., Mester M., Filipovic M., Sever M., Klicek R., Barisic I., Radic B., Zoricic Z., Bilic V., Berkopic L., Brcic L., Kolenc D., Romic Z., Pazanin L., Seiwerth S., Sikiric P., Seiwerth S., Sikiric P.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 7

7

Depression of interferon production in leukocytes of cows with fat mobilization syndrome

70%

Szuster-Ciesielska A., Filar J., Kandefer-Szerszen M.

Archivum Immunologiae et Therapiae Experimentalis

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1995

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tom 43

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nr 1

8

Zachowanie sie wybranych wskaznikow hematologicznych i biochemicznych u kaczek mieszancow przygotowywanych do tuczu na stluszczone watroby

61%

Krasnodebska-Depta A., Koncicki A., Wawro K.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1997

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tom 25

77-84

Badania przeprowadzono na 200 kaczkach mieszańcach (kaczor piżmowy x kaczka Pekin z rodu A-44), które podzielono na dwie grupy po 50 samic i 50 samców każda. Doświadczenie obejmowało 12-tygodniowy okres odchowu. Ptaki były żywione do woli. Kaczki z grupy doświadczalnej od 4. do 12. tygodnia życia otrzymywały paszę o zmniejszającej się zawartości białka, a od 7. do 12. tyg. - o zwiększającej się zawartości energii metabolicznej, co uzyskiwano przez stosowanie w mieszance 20-procentowego udziału śruty owsianej (7-11 tydz.), 10- i 25-procentowego udziału kukurydzy, odpowiednio w 10. 11. tyg., a w 12. tyg. - żywienia samą kukurydzą. Stosowana dieta nie wywarła wpływu na badane wskaźniki hematologiczne (Ht, Hb, RBC, WBC), nie zmieniła aktywności enzymów (AST, ALT, AP), w surowicy natomiast spowodowała wzrost zawartości w surowicy cholesterolu całkowitego i lipidów całkowitych oraz obniżenie zawartości białka całkowitego, glukozy i wapnia.

Ograniczanie wyników

High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)

Rearing and fattening performance of variously fed crossbreeds of Muscovy drakes and Pekin-type ducks

Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver

Zastosowanie rozdrobnionej i natluszczonej kukurydzy w tuczu gesi i kaczek na stluszczone watroby

Is fatty liver always benign and should not consequently be treated?

Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats

Depression of interferon production in leukocytes of cows with fat mobilization syndrome

Zachowanie sie wybranych wskaznikow hematologicznych i biochemicznych u kaczek mieszancow przygotowywanych do tuczu na stluszczone watroby