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1
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Liver X receptor agonist T0901317 enhanced peroxisome proliferator-activated receptor-delta expression and fatty acid oxidation in rat skeletal muscle

100%
Baranowski M., Blachnio-Zabielska A. U., Zabielski P., Harasim E., Harasiuk D., Chabowski A., Gorski J.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 3
2

Effects of genistein on insulin pathway-related genes in mouse differentiated myoblast C2C12 cell line: evidence for two independent modes of action

100%
Lewicki S., Lewicka A., Kalicki B., Sobolewska-Ruta A., Debski B., Zdanowski R., Syrylo T., Kloc M., Kubiak J. Z.
Folia Histochemica et Cytobiologica
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2018
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tom 56
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nr 3
3
Content available remote

Several statins increase body and liver fat accumulation in a model of metabolic syndrome

80%
Aguirre L., Hijona E., Macarulla M. T., Gracia A., Larrechi I., Bujanda L., Hijona L., Portillo M. P.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 3
4
Content available remote

Effects of hyperthyroidism on lipid content and composition in oxidative and glycolytic muscles in rats

80%
Miklosz A., Chabowski A., Zendzian-Piotrowska M., Gorski J.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 4
5

Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine

80%
Skierczynska A., Beresewicz A.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 2
6
Content available remote

Role of adiponectin in the regulation of carbohydrate and lipid metabolism

80%
Karbowska J., Kochan Z.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 6
103-113
Adiponectin, an adipocyte-derived plasma protein, has been shown to play an important role in the regulation of fatty acid and glucose metabolism. Adiponectin enhances fatty acid oxidation both in skeletal and cardiac muscle as well as in the liver, thus reducing triglyceride content in these tissues. Moreover, it stimulates glucose uptake by skeletal and cardiac muscle, and inhibits glucose production by the liver; consequently decreasing blood glucose levels. This review focuses on the molecular mechanisms underlying adiponectin effects on carbohydrate and lipid metabolism in skeletal muscle, cardiac muscle and liver.
7
Content available remote

Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation

80%
Dobrzyn A., Dobrzyn P.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 10
31-42
Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are a major component of tissue lipids. SCD1 deficient mice reveal increased energy expenditure and decreased body adiposity due to the upregulation of genes of fatty acid oxidation and the downregulation of genes of lipid synthesis in liver. In this review, we examine data showing that SCD is an important component in the regulation of skeletal muscle metabolism, which affects insulin sensitivity, mitochondrial fatty acid oxidation and ceramide de novo synthesis in oxidative myofibers. The lack of SCD1 gene increases the rate of fatty acid ß-oxidation through activation of the AMP-activated protein kinase (AMPK) pathway and by upregulating genes of fatty acid oxidation in soleus and red gastrocnemius muscles. Consistent with increased ß-oxidation, the contents of free fatty acids and long-chain acyl-CoAs are significantly decreased, which together with reduced mRNA level and activity of serine palmitoyltransferase led to reduced ceramide synthesis in oxidative muscles of SCD1-/- mice. Thus, reduced contents of free fatty acids, acyl-CoAs and ceramides as well as increased AMPK phosphorylation, might contribute to increased insulin sensitivity observed in muscle of SCD1-/- mice. SCD1 deficiency also results in downregulation of the expression of the protein-tyrosine phosphatase 1B, which is responsible for the sustained insulin receptor autophosphorylation despite reduced levels of plasma insulin in the SCD1-/- mice. SCD1 deficiency reduced ceramide synthesis, increased AMPK phosphorylation and carnitine palmitoyltransferase 1 activity also in soleus and red gastrocnemius muscles of leptin deficient ob/ob mice. These findings raise the possibility that SCD1 may be a downstream component of the leptin signaling pathway in skeletal muscle.
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