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Effects of extremely low frequency magnetic field on the parameters of oxidative stress in heart

100%

Goraca A., Ciejka E., Piechota A.

Journal of Physiology and Pharmacology

2010

tom 61

nr 3

333-338

Increasing production of free radicals in organisms is one of the putative mechanisms by which a extremely low frequency magnetic field (ELF-MF) may affect biological systems. The present study was designated to assess if ELF-MF applied in the magnetotherapy, affects generation of reactive oxygen species (ROS) in heart tissue and antioxidant capacity of plasma according to its working time. The experiments were performed on 3 groups of animals: group I - control; group II - exposed to 40 Hz, 7 mT, 30 min/day for 14 days (this field is commonly applied in magnetotherapy); group III - exposed to 40 Hz, 7 mT, 60 min/day for 14 days. Control rats were housed in a separate room without exposure to ELF-MF. Immediately after the last exposure, blood was taken from the tail vein and hearts were removed under anesthesia. The effect of the exposure to ELF-MF on oxidative stress was assessed on the basis of the measurements of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H2O2), total free sulphydryl groups (-SH groups) and reduced glutathione (GSH) concentrations in heart homogenates. The total antioxidant capacity of plasma was measured using ferric reducing ability method (FRAP). Exposure to ELF-MF (40 Hz, 7 mT, 30 min/day for 2 weeks) did not significantly alter tissue TBARS, H2O2, total free -SH groups, reduced glutathione (GSH) and total antioxidant capacity of plasma. By contrast, ELF-MF with the same frequency and induction but used for 60 min/day for 14 days caused significant increase in TBARS and H2O2 concentration (P<0.01) and decrease in the concentration of GSH (P<0.05) and total free -SH groups in heart homogenates. Moreover, exposure of rats to ELF-MF (40 Hz, 7 mT, 60 min/day for 2 weeks) resulted in the decrease of plasma antioxidant capacity. Our results indicate that effects of ELF-MF on ROS generation in the heart tissue and antioxidant capacity of plasma depend on its working time.

Effects of extremely low frequency magnetic field on oxidative balance in brain of rats

80%

Ciejka E., Kleniewska P., Skibska B., Goraca A.

Journal of Physiology and Pharmacology

2011

tom 62

nr 6

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

2 Ciejka E.

2 Goraca A.

1 Kleniewska P.

1 Piechota A.

1 Skibska B.

1 2011

1 2010

Wyniki wyszukiwania

Effects of extremely low frequency magnetic field on the parameters of oxidative stress in heart

Effects of extremely low frequency magnetic field on oxidative balance in brain of rats