Wyniki wyszukiwania

1

Solute-free water retention in preascitic cirrhotic rats following intravenous water loading

100%

Sansoe G., Aragno M., Smedile A., Rizzetto M., Rosina F.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

111-117

Increased extracellular fluid volume (ECF) characterizes compensated cirrhosis. To identify the mechanisms of fluid retention in cirrhosis through clearance methods, 10 control and 10 preascitic rats with CCl4-induced cirrhosis were studied following i.v. loading with 1 ml 5% glucose solution. Glomerular filtration rate and renal plasma flow were evaluated through inulin and para-aminohippurate clearances; water and electrolyte handling was assessed measuring urine and plasma osmolarity, electrolyte excretions, and tubular solute-free water reabsorption (TFWR = osmolar clearance minus urinary output); ECF was assessed through hormonal status determination. After water loading, cirrhotic rats had increased ECF (lower plasma renin activity and aldosterone and higher atrial natriuretic peptide levels, all P<0.03), solute-free water retention (increased TFWR and decreased plasma osmolarity, all P<0.05), reduced absolute and fractional sodium excretions (P<0.05). Cirrhotic rats showed sodium retention in the medullary thick ascending limb of Henle’s loop (i.e. increased values of TFWR for any given value of osmolar clearance). Trans-tubular potassium gradient in medullary collecting duct was similar in the two groups (P=0.55), ruling out aldosterone-dependent sodium retention and potassium hyper-secretion. In experimental preascitic cirrhosis NaCl retention in the ascending limb of Henle’s loop increases medullary interstitial tonicity leading to vasopressin-independent water back-diffusion in thin descending limb of Henle’s loop and collecting duct.

2

Effect of K accumulation removal and high extracellular osmolarity on K current in insect axonal membrane

67%

Stankiewicz M., Pelhate M., Pancerzynska I., Zienkiewicz A., Kadziela W.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 1

3

ATP-regulated potassium channel

67%

Szewczyk A., Wojtczak L.

Biophysics of Membrane Transport

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1994

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tom 12

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nr 2

4

Effects of caffeine on NMDA-evoked 45 Ca2 release in the rat dentate gyrus in vivo

59%

Alaraj M., Kosinska I., Lazarewicz J. W.

Acta Neurobiologiae Experimentalis

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1998

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tom 58

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nr 4

Ograniczanie wyników

2 Acta Neurobiologiae Experimentalis

1 Biophysics of Membrane Transport

1 Journal of Physiology and Pharmacology

1 Alaraj M.

1 Aragno M.

1 Kadziela W.

1 Kosinska I.

1 Lazarewicz J. W.

1 Pancerzynska I.

1 Pelhate M.

1 Rizzetto M.

1 Rosina F.

1 Sansoe G.

1 Smedile A.

1 Stankiewicz M.

1 Szewczyk A.

1 Wojtczak L.

1 Zienkiewicz A.

1 2009

1 1998

1 1996

1 1994

Solute-free water retention in preascitic cirrhotic rats following intravenous water loading

Effect of K accumulation removal and high extracellular osmolarity on K current in insect axonal membrane

ATP-regulated potassium channel

Effects of caffeine on NMDA-evoked 45 Ca2 release in the rat dentate gyrus in vivo