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1
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The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats

100%
Kapica M., Laubitz D., Puzio I., Jankowska A., Zabielski R.
Journal of Physiology and Pharmacology
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2006
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tom 57
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nr 4
Ghrelin, a 28 amino acids polypeptide was recognized as an endogenous ligand for the growth hormone secretagogue receptor. It turned out that the entire sequence of ghrelin is not necessary for performing the above-mentioned functions. It was suggested that 5 residues (Gly-Ser-Ser(n-octanoyl)-Phe, pentaghrelin) constituted functionally active part of the full-length polypeptide. Ghrelin-28 was found to inhibit pancreatic enzyme output in rats, though the effect of pentaghrelin was not studied so far. The study aimed to determine the involvement of pentaghrelin in pancreatic juice secretion in anaesthetized rats. Male Wistar rats (220 ± 20 g body weight, b. wt.) were anesthetized, the external jugular vein and common biliary-pancreatic duct were cannulated. Pentaghrelin boluses (iv, 1.2, 12, and 50 nmol kg-1 b. wt.) were injected every 30 min with or without CCK-8 infusion, duodenal mucosal CCK1 receptor blockade with tarazepide, vagotomy and capsaicin pretreatment. Pentaghrelin boluses reduced the volume of pancreatic-biliary juice, protein and trypsin outputs both under basal and CCK-8-stimulated conditions in a dose-dependent manner. However, exogenous pentaghrelin failed to affect the pancreatic secretion in rats subjected to vagotomy, capsaicin deactivation of afferents or pretreatment with Tarazepide. In conclusion, pentaghrelin may control exocrine pancreas secretion by affecting duodenal neurohormonal mechanism(s) involving CCK and vagal nerves in rats.
2
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Exocrine pancreas; molecular basis for intracellular signaling, damage and protection - Polish experience

84%
Dabrowski A.
Journal of Physiology and Pharmacology. Supplement
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2003
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tom 54
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nr 3
167-181
Polish experience in molecular pancreatology mostly involves experimental work on intracellular signal transduction mechanisms in pancreatic acinar cells. It was found that stimulation with cholecystokinin (CCK) or exposure of pancreatic acini to reactive oxygen species induces three separate signaling cascades leading to activation of ERKs, JNK/SAPKs and p38 MAPK. In pancreatic acini, ERK cascade is also activated by epidermal growth factor (EGF). However, CCK and EGF activate this cascade by different mechanisms. EGF activates the cascade in a classical Ras-dependent manner, while CCK-induced activation of the ERK cascade is Ras-independent. Furthermore, stimulation with CCK leads to a rapid activation of PKC, which in turn may directly activate Raf family of kinases. Freshly isolated pancreatic acini contain pancreatic stellate cells which respond to EGF by activation of ERK cascade. It is possible that stimulation with CCK and EGF induces a cross-talk between acinar and stellate cells. Isolated pancreatic acinar cells irradiated with UV-B die predominantly by apoptosis while necrosis predominates among the cells subjected to supraphysiological concentrations of CCK. In pancreatic acini subjected to stressful stimuli the regulation of apoptosis may involve interaction between ERK and p38 MAPK signaling pathways. Acute pancreatitis in rats and in humans is associated with a marked increase in the plasma level of leptin which is caused by increased production of this peptide in the inflamed pancreas. It is possible that exogenous leptin protects the pancreas against development of acute pancreatitis by the activation of nitric oxide pathway.
3

Morphobiochemical studies on alpha-amylase secretion by pancreatic follicles of guinea pigs after the application of exogenous histamine

84%
Kmiec B. L., Andrysiak P. K.
Folia Histochemica et Cytobiologica
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1997
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tom 35
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nr 2
4
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Antagonism of receptors for gastrin, cholecystokinin and GRP-bombesin in postprandial stimulation of exocrine pancreas in dogs

84%
Konturek S. J., Tasler J., Bilski J., Cieszkowski M., Cai R-Z., Schally A. V.
Journal of Physiology and Pharmacology
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1993
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tom 44
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nr 1
5

Central and peripheral control of pancreatic integrity by leptin and melatonin

67%
Jaworek J.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
6

Epidermal growth factor signalling in rat pancreatic acinar cells

59%
Stryjek-Kaminska D.
Journal of Physiology and Pharmacology. Supplement
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1998
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tom 49
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nr 1
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