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Influence of diazepam on the escape reaction and rabbits' behaviour under stress

100%

Czabak-Garbacz R., Chomicki M., Cygan B., Khonicheva N. M.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 4

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Influence of the new benzodiazepine derivative BD-1158 on the behaviour of rabbits under stress conditions

100%

Cygan B., Wojcik G., Czabak-Garbacz R., Teter M., Kozlovsky I.

Bulletin of the Veterinary Institute in Puławy

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2001

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tom 45

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nr 2

BD-1158 is a new 1,4 benzodiazepine derivative. The purpose of the present experiments was to test the influence of this substance on the behaviour of rabbits under stress conditions, induced by electrical stimulation of ventromedial nucleus of the hypothalamus (VMH). The experiments were performed for 4 subsequent days in a group of 10 rabbits. On the first day the electrode was implanted into VMH. On the second day the spontaneous behaviour in stress conditions was tested. On the third day 1 ml of 1 % starch solution was administered intraperitoneally. On the fourth day BD-1158 was administered intraperitoneally at a dose 10mg/kg diluted in starch solution up to 1 ml, 35 minutes before the beginning of the experiment. Six phases of behaviour were estimated. It was concluded that in extreme conditons BD-1158 has a strong anxiolytic and sedative effect. lts influence concerns a considerable extension of the comfort phase and decrease of the tension phase. BD-1158 does not influence the animals' activity and attention (the orientation-searching phase and grooming). It decreases eating and drinking.

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Influence of short peptides on the escape reaction induced by stimulation of nucleus ventromedialis of hypothalamus in rabbits

84%

Dec-Szlichtyng M., Teter M., Borowicz B.

Bulletin of the Veterinary Institute in Puławy

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2001

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tom 45

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nr 2

The aim of the study was to test the influence of tuftsin analogue TP- 1, its terminal fragment- tetrapeptide Arg-Pro-Gly-Pro and L-arginine on the escape reaction induced by electric stimulation of nucleus ventromedialis of the hypothalamus (Vmh). The experiments were carried out on 29 male rabbits of the Chinchilla breed (2900-3500g). The studied substances were administered in doses of 0.5 μmol/kg of body weight into lateral cerebral ventricle (icv). The period of experiment (3h) was divided into 10-min intervals. Vmh stimulation was performed every 10 min (18 stimulations). The latency time (LT) of escape reaction was considered to be the period between the beginning of Vmh stimulation and the escape reaction. Each of tested substances caused a significant increase of LT of the escape reaction. The increase of LT after icv administration of L-arginine was statistically smaller than the increase of LT after icv administration of tetrapeptide and TP-1.

Ograniczanie wyników

3 Bulletin of the Veterinary Institute in Puławy

2 Cygan B.

2 Czabak-Garbacz R.

2 Teter M.

1 Borowicz B.

1 Chomicki M.

1 Dec-Szlichtyng M.

1 Khonicheva N. M.

1 Kozlovsky I.

1 Wojcik G.

1 2004

2 2001

Influence of diazepam on the escape reaction and rabbits' behaviour under stress

Influence of the new benzodiazepine derivative BD-1158 on the behaviour of rabbits under stress conditions

Influence of short peptides on the escape reaction induced by stimulation of nucleus ventromedialis of hypothalamus in rabbits