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  1. 10 Archivum Immunologiae et Therapiae Experimentalis

  2. 3 Annals of Animal Science

  3. 3 BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

  4. 2 Acta Parasitologica

  5. 2 Polish Journal of Food and Nutrition Sciences

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  1. 4 Skiba E.

  2. 4 Wegrzyn J.

  3. 3 Krzyscin P.

  4. 3 Sidorczyk Z.

  5. 2 Darewicz M.

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  1. 1 2023

  2. 1 2021

  3. 1 2020

  4. 1 2019

  5. 1 2018

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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Identification of CD4plus T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking

100%
Francis D., Kumar A., Chittalakkottu S.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2021
|
tom 102
|
nr 1
2

Repeat region of Brugia malayi sheath protein (Shp-1) carries Dominant B epitopes recognized in filarial endemic population

100%
Jawaharlal J. P. P., Madhumathi J., Prince R. P., Kaliraj P.
Acta Parasitologica
|
2014
|
tom 59
|
nr 3
Transmission of lymphatic filariasis is mediated through microfilariae (L1 stage of the parasite) which is encased in an eggshell called sheath. The sheath protein Shp-1 stabilizes the structure due to the unique repeat region with Met-Pro-Pro-Gln-Gly sequences. Microfilarial proteins could be used as transmission blocking vaccines. Since the repeat region of Shp-1 was predicted to carry putative B epitopes, this region was used to analyze its reactivity with clinical samples towards construction of peptide vaccine. In silico analysis of Shp-1 showed the presence of B epitopes in the region 49–107. The polypeptide epitopic region Shp-149–107 was cloned and expressed in Escherichia coli. Antibody reactivity of the Shp-149–107 construct was evaluated in filarial endemic population by ELISA. Putatively immune endemic normals (EN) showed significantly high reactivity (P < 0.05) when compared to all the other categories. Antibody reactivity of Shp-1 repeat region was similar to that of whole protein proving that this region carries B epitopes responsible for its humoral response in humans. Thus this can be employed for inducing anti-microfilarial immunity in the infected population that may lead to reduction in transmission intensity and also it could be used along with other epitopes from different stages of the parasite in order to manage the disease effectively.
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Epitope prediction, modeling, and docking studies for H3L protein as an agent of smallpox

100%
Mohammadi E., Dashty S.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2019
|
tom 100
|
nr 1
4

Ig[l-k]A1 - antigenic marker of light-chain immunoglobulins in pigs

100%
Wegrzyn J., Skiba E.
Roczniki Naukowe Zootechniki
|
2000
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tom 27
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nr 2
5

Epitopes of blood proteins in sheep and the nomenclature

100%
Skiba E., Wegrzyn J., Koscielny M.
Roczniki Naukowe Zootechniki
|
2000
|
tom 27
|
nr 2
6

Serological classification and epitope specificity of Proteus vulgaris TG 251 from Proteus serogroup 065

100%
Zych K., Kolodziejska K., Drzewiecka D., Perepelov A. V., Knirel Y. A., Sidorczyk Z.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
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tom 55
|
nr 3
7

Synthesis of alpha2- and beta-macroglobulins [carriers of A2mA1 and BmgB1 epitopes] and expression of genes determining them in sheep

100%
Wegrzyn J., Skiba E., Kaczor U.
Animal Science Papers and Reports
|
2002
|
tom 20
|
nr 3
8

Quantification of the CD8plus T cell response against a mucin epitope in patients with breast cancer

100%
Kokowski K., Harnack U., Dorn D. C., Pecher G.
Archivum Immunologiae et Therapiae Experimentalis
|
2008
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tom 56
|
nr 2
9
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The occurrence of sequences identical with epitopes from the allergen pen a 1.0102 among food and non-food proteins

84%
Minkiewicz P., Sokolowska J., Darewicz M.
Polish Journal of Food and Nutrition Sciences
|
2015
|
tom 65
|
nr 1
The presence of common epitopes among tropomyosins of invertebrates, including arthropods, e.g. edible ones, may help to explain the molecular basis of cross-reactivity between allergens. The work presented is the fi rst survey concerning global distribution of epitopes from Pen a 1.0102 in universal proteome. In the group of known tropomyosin epitopes, the fragment with the sequence ESKIVELEEEL was found in the sequence of channel catfish (Ictalurus punctatus) tropomyosin. To date, this is the fi rst result suggesting the presence of a complete sequential epitope interacting with IgE in vertebrate tropomyosin. Another fragment with the sequence VAALNRRIQL, a major part of the epitope, was found in 11 fi sh, 8 amphibians, 3 birds, 19 mammalians and 4 human tropomyosin sequences. Identical epitopes are common in sequences of invertebrate tropomyosins, including food and non-food allergens annotated in the Allergome database. The rare pentapeptide with the DEERM sequence occurs in proteins not sharing homology with tropomyosins. Pathogenic microorganisms are the most abundant category of organisms synthesizing such proteins.
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Databases and associated bioinformatic tools in studies of food allergens, epitopes and haptens - a review

84%
Bucholska J., Minkiewicz P., Darewicz M., Iwaniak A.
Polish Journal of Food and Nutrition Sciences
|
2018
|
tom 68
|
nr 2
Allergies and/or food intolerances are a growing problem of the modern world. Diffi culties associated with the correct diagnosis of food allergies result in the need to classify the factors causing allergies and allergens themselves. Therefore, internet databases and other bioinformatic tools play a special role in deepening knowledge of biologically-important compounds. Internet repositories, as a source of information on different chemical compounds, including those related to allergy and intolerance, are increasingly being used by scientists. Bioinformatic methods play a signifi cant role in biological and medical sciences, and their importance in food science is increasing. This study aimed at presenting selected databases and tools of bioinformatic analysis useful in research on food allergies, allergens (11 databases), epitopes (7 databases), and haptens (2 databases). It also presents examples of the application of computer methods in studies related to allergies.
11

Human plasma and cerebrospinal fibronectins differ in the accessibility of the epitopes on the N-terminal domains

84%
Pupek M., Lemanska-Perek A., Jasonek J., Katnik-Prastowska I.
Acta Biochimica Polonica
|
2010
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tom 57
|
nr 3
 Three monoclonal antibodies specific to the central cell-binding and the C- and N-terminal domains of fibronectin (FN) were used to test antigenic epitope accessibility on human plasma and cerebrospinal fibronectins. In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were nearly equal. In the presence of 0.5-6 M urea N-terminal domain immunoreactivity in the plasma increased 3-6-fold, but it decreased 0.7-3-fold in the cerebrospinal fluid. Analysis of fibronectin domain immunoreactivities of the cell-binding and N-terminal domains by a panel of specific monoclonal antibodies may reveal N-terminal fibronectin domain accessibility for reaction with biological partner ligand(s) and/or processes in which FN could be implicated. Such determinations may have important clinical implications.
12

Antigenic markers of sheep plasma globulins in predicting resistance to mammary gland infections

84%
Krzyscin P.
Annals of Animal Science
|
2006
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tom 06
|
nr 2
13

Prediction and identification of epitopes in the Emy162 antigen of Echinococcus multilocularis

84%
Pang M.-Q., Tang F., Wang H.-J., Zhou Y., Ren L., Li R.-L., Zhou H., Wan C.-F., Liu C.-C., Yangdan C.-R., Fan H.-N.
Acta Parasitologica
|
2020
|
tom 65
|
nr 4
14

CD4plus T cell epitope discovery and rational vaccine design

84%
Rosa D. S., Ribeiro S. P., Cunha-Neto E.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
|
tom 58
|
nr 2
121-130
15

Epitope spreading: a mechanism for progression of autoimmune disease

84%
Tuohy V. K., Kinkel R. P.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 5
16

Advanced glycation end-products prepared in solution under high pressure contain epitopes distinct from those formed in the dry reaction at high temperature

84%
Staniszewska M., Jarosz S., Jon M., Gamian A.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
tom 53
|
nr 1
17

Epitopes in beta-globulin absorption and BGA1 and BMIA1 gene expression studies in lambs

84%
Krzyscin P., Skiba E., Wegrzyn J.
Annals of Animal Science
|
2002
|
tom 02
|
nr 2
18

Application of two different kinds of sera against the Proteus penneri lipopolysaccharide core region in search of epitopes determining cross-reactions with antibodies

84%
Palusiak A., Dzieciatkowska M., Sidorczyk Z.
Archivum Immunologiae et Therapiae Experimentalis
|
2008
|
tom 56
|
nr 2
19

Mycobacterium-specific human CD8 T cell responses

84%
Klein M. R., Fox A.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
|
tom 49
|
nr 5
20

Human antibody production in transgenic animals

67%
Bruggmann M., Osborn M. J., Ma B., Hayre J., Avis S., Lundstrom B., Buelow R.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
|
tom 63
|
nr 2
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