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Litogenolitic and solubility properties of products obtained from common ivy extract (Hederae helicis e folium) and medium of diversified polarity (ԐM)

100%

Nowak E., Marczynski Z., Skibska B., Nachajski M. J., Jambor J., Zgoda M. M.

Herba Polonica

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2019

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tom 65

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nr 1

Introduction: Common ivy (Hedera helix) is a plant used successfully in the treatment of various ailments. This is possible owing to the unique set of substances contained in it such as large amount of saponins, flavonoids, phenolic acids and phytosterols as well as polyacetylenes and coumarins. All these substances have been used in the production of cosmetic and medicinal preparations. Clinical trials on the efficacy and safety of dry ivy leaf extract have shown its high efficacy, comparable to synthetic medications, and better tolerance of herbal drugs. Objective: Investigations were performed on model ivy leaf (Hedera helix) extracts which were created using a medium of diversified polarity (ԐM). Measurements of viscosity and surface activity on phase boundary were performed. During preformulation studies attention was drawn to the possibility of micellar solubilization of cholesterol and selected structures of nonsteroidal anti-inflammatory drugs (NSAIDs) – ketoprofen. Methods: Viscosity measurements of Extractum Hederae helicis e folium aqueous solutions and in 0.1 mol HCl were performed according to the Polish Standard with Ubbelohde dilution viscometer. The surface tension of aqueous solutions – Δγ25 of Hederae helicis e folium extracts was determined according to the Polish Standard with stalagmometric method . Critical micellar concentration (cmc) was calculated. This enabled to evaluate the dependence ΔG0 =2.303 RT× log cmc of the thermodynamic potential of micelle formation (ΔG0 ). Results: It has been confirmed in the conducted comparative studies that aqueous solutions of Extr. Hederae helicis e folium created with maltodextrin as well as with SiO2 – maltodextrin result in micellar solubilization. The increase of granulometric size of cholesterol particle to Ø 1.60 mm decreased the amount of solubilized cholesterol but solubility preferences of the extracts were maintained. Conclusions: Model extracts produced from Hederae helicis e folium with diversified polarity of the extraction medium (water – ethanol) are characterized by appropriate solubility of the components which results not only from the presence of chlorophyll and its derivatives in the extract but also from the technique used for spray drying of the extract.

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Permeation-enhancing properties of Nepeta cataria var. citriodora dry extract

100%

Winnicki A. M., Smieszek J. M., Partyka D., Modnicki D.

Herba Polonica

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2013

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tom 59

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nr 3

This paper presents the research on permeation enhancing properties of Nepeta cataria var. citriodora (catnip) dry extract in comparison to oleanolic acid and ursolic acid. Progesterone was chosen as a model substance for permeation test. The hydrogels made of hydroxypropylmethylcellulose with progesterone, enhancers and ethanol were applied in the study. The in vitro progesterone penetration test was based on the method proposed by Fürst, using artificial lipophilic membranes which were made of colloxylin and dodecanol. Statistical analyses showed an increase in penetration of progesterone caused by catnip dry extract in comparison to ursolic acid and blank sample. HPLC assay was applied to study the effect of enhancers on progesterone physicochemical properties. The solubility of progesterone was tested in solvent systems corresponding to liquid phases of gels. The statistical increase in progesterone solubility was observed in the presence of dry extract in comparison to the result from ursolic acid-containing sample. The partition coefficient of progesterone was evaluated by standard procedures. The statistically significant reduction of log P values for progesterone was determined in the presence of catnip dry extract.

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A new herbal remedy of anabolic activity on the basis of hydrophilic compounds of Eucalyptus leaves

100%

Koshoviy O. M., Kyslichenko V. S., Velma V. V., Komisarenko A. M.

Herba Polonica

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2009

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tom 55

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nr 1

72-77

Arnica sp. infusions and tinctures play a great role in the traditional and contemporary medicine. Seeds of plantation-grown Arnica montana L. (AM) and Arnica chamissonis var. foliosa Less. (AC ) are a good source of bioactive compounds such as phenolic acids and flavonoids. In both studied genera higher levels of phenolic acids and flavonoids were detected in water extracts. Regardless of plant genus, predominant fractions of phenolics were determined in seeds, comprising chlorogenic, caffeic acid, quercetin and kaempferol. All samples show high antioxidant activity, however, their levels depend on the extraction procedure and used material. The free radicals were scavenged most effectively by extracts of AC seeds (30.3% – SASA, 31.3% – DPPH and 39.8% – ABTS, respectively). It should be noted that lipid peroxidation was strongly inhibited by both studied tinctures. It is noteworthy that studied samples show positive correlations between inhibition of lipid peroxidation ability and total flavonoids and phenolic acids content (r=0.89 and r=0.83, respectively). Results obtained from this study show that Arnica seeds extract, either alone or in combination with other active principles, can be used in cosmetic, nutraceutical and pharmaceutical applications.

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The effect of auxiliary substances on pharmaceutical availability of medicinal substances contained in dry extract from small-flowered willow herb [Epilobium parviflorum Schreb.]

100%

Marczynski Z., Zgoda M.

Herba Polonica

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2005

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tom 51

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nr 1-2

Therapeutic agents of natural origin, administered in prostatic disorders, have wider experimental and clinical documentation than the synthetic medicines, fashionable, butrela- t/ve/y new on the market. Their superiority is based first of all on versatile points of effect, almost total lack of side effects and a significantly low cost of therapy. Bearing in mind the above mentioned, an attempt was made to produce an oral solid form of a drug from dry aqueous extract of small-flowered willow herbs (E. parviflorum), using some formulating components of variable adsorptive properties. Taking into account the composition and granulometric properties of the extract, two alternative technological processes have been suggested to produce oral solid model pharmaceutical agents. These model forms were subjected to the following morphological tests determining: the appearance of tablets, their mass, friability and effective disintegration time. Furthermore, pharmaceutical availability of the model form of the drug was investigated. The effect of formulating components on the course of quantitative determination of active agents was assessed in the tablets.

Ograniczanie wyników

4 Herba Polonica

2 Marczynski Z.

1 Jambor J.

1 Komisarenko A. M.

1 Koshoviy O. M.

1 Kyslichenko V. S.

1 Modnicki D.

1 Nachajski M. J.

1 Nowak E.

1 Partyka D.

1 Skibska B.

1 Smieszek J. M.

1 Velma V. V.

1 Winnicki A. M.

1 Zgoda M.

1 Zgoda M. M.

1 2019

1 2013

1 2009

1 2005

Litogenolitic and solubility properties of products obtained from common ivy extract (Hederae helicis e folium) and medium of diversified polarity (ԐM)

Permeation-enhancing properties of Nepeta cataria var. citriodora dry extract

A new herbal remedy of anabolic activity on the basis of hydrophilic compounds of Eucalyptus leaves

The effect of auxiliary substances on pharmaceutical availability of medicinal substances contained in dry extract from small-flowered willow herb [Epilobium parviflorum Schreb.]