Wyniki wyszukiwania

1

Targeted drug delivery for anthracyclins using peptidoliposomal constructs

100%

Kaukinen S., Kuosmanen S., Valtanen H., Zhu Y., Simpura I., Haikola M., Tahtinen M., Reinman M., Medina O. P., Kairemo K.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.

2

The macromolecular aggregate as a drug carrier

75%

Langer M., Ugorski M.

Cellular and Molecular Biology Letters

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2000

|

tom 05

|

nr 4

433-440

Traditionally, a drug is expected to be biologically active and at the same time be able to ensure some sort of tissue or organ specificity. The latter property is necessary to avoid undesirable side effects when toxic drugs are being used. Such requirements are difficult to achieve only by changing the chemical formula of the drug. For these reasons, within the last few years a new pharmacological concept has been developed regarding delivery of biologically active compounds by the use of macromolecular aggregates. The purpose-specific design of macromolecular aggregates, able to deliver drugs to a desired location, is based on the assumption that different functions can be assigned to the separate chemical entities forming the aggregate. With the help of such an aggregate, the biologically active compound can be designed with solely its pharmacological potency in mind and without considering any limitations imposed by inaccurate delivery, such as undesired side effects. Specific molecules of the aggregate would ensure desired compound distribution within the organism. Furthermore, other molecules forming the aggregate should fulfill additional functions, e.g. protecting the drug from degradation. Additionally, aggregates formed from amphiphilic molecules should be capable of carrying drugs that are difficult to use as therapeutic agents due to low solubility in biological fluids (e.g. Taxol) or degradation (e.g. peptides, DNA). Such aggregates can be constructed from natural or/and synthetic compounds. Taken together, this creates possibilities of extending the spectrum of drug application and allows for the introduction of new technological modifications.

3

Targeted multimodal liposomes for imaging and radionuclide therapy

75%

Koning G. A., Mulder W., Strijkers G. J., Nicolay K., Zielhuis S., Nijsen F., Fretz M. M., Storm G., Krijger G. C.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.

4

Plarosomes, novel efficient phospholipid-amphiphile vesicles for drug delivery

75%

Kozubek A., Gubernator J., Przeworska E., Stasiuk M.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 2

5

Electrically assisted transdermal drug delivery of liposomal formulations

75%

Betageri G. V.

Cellular and Molecular Biology Letters

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1999

|

tom 04

|

nr 2

6

Development of new controlled release formulations for the delivery of a curcumin derivative using liposomes and dendrimers

75%

Markatou E., Hatziantoniou S., Pantazis P., Demetzos C.

Cellular and Molecular Biology Letters

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2005

|

tom 10

|

nr Suppl.

7

Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier

63%

Grabacka M., Waligorski P., Zapata A., Blake D. A., Wyczechowska D., Wilk A., Rutkowska M., Vashistha H., Ayyala R., Ponnusamy T., John V. T., Culicchia F., Wisniewska-Becker A., Reiss K.

Journal of Physiology and Pharmacology

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2015

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tom 66

|

nr 2

8

Application of aptamers for targeted therapeutics

63%

Ray P., Viles K. D., Soule E. E., Woodruff R. S.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

|

nr 4

9

Nanostructure-based therapies for liver fibrosis

63%

Zugravu Pop D. D., Mitrea D. R., Suciu S., Clichici S. V.

Journal of Physiology and Pharmacology

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2020

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tom 71

|

nr 6

10

Biodegradable polymeric micelles based on thermosensitive poly[[methacrylamido]alkyl oligolactate] for delayed drug delivery

63%

Van Nostrum C. F., Soga O., Rijcken C. J. F., Ramzi A., Veldhuis T. F. J., Hennink W. E.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.

11

Novel approaches to enhance pulmonary delivery of proteins and peptides

51%

Scheuch G., Siekmeier R.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

Ograniczanie wyników

Targeted drug delivery for anthracyclins using peptidoliposomal constructs

The macromolecular aggregate as a drug carrier

Targeted multimodal liposomes for imaging and radionuclide therapy

Plarosomes, novel efficient phospholipid-amphiphile vesicles for drug delivery

Electrically assisted transdermal drug delivery of liposomal formulations

Development of new controlled release formulations for the delivery of a curcumin derivative using liposomes and dendrimers

Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier

Application of aptamers for targeted therapeutics

Nanostructure-based therapies for liver fibrosis

Biodegradable polymeric micelles based on thermosensitive poly[[methacrylamido]alkyl oligolactate] for delayed drug delivery

Novel approaches to enhance pulmonary delivery of proteins and peptides