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Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion

100%

Rempola B., Kaniak A., Di Rago J. P., Rytka J.

Acta Biochimica Polonica

2001

tom 48

nr 4

Saccharomyces cerevisiae homologues of phosphotyrosyl phosphatase activator (PTPA) are encoded by RRD1 and RRD2, genes whose combined deletion is synthetic lethal. Previously we have shown that the lethality of rrd 1,2Δ can be suppressed by increasing the osmolarity of the medium. Here we show that the lethality of rrd1,2Δ is also suppressed under oxygen-limited conditions. The absence of respiration perse is not responsible for the suppression since elimination of the mitochondrial genome or a block in heme biosynthesis fail to rescue the rrd1,2Δ double mutation.

Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer

80%

Palmirotta R., Savonarola A., Ludovici G., De Marchis M. L., Covello R., Ettorre G. M., Ialongo C., Guadagni F.

Folia Histochemica et Cytobiologica

2011

tom 49

nr 4

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Folia Histochemica et Cytobiologica

1 Covello R.

1 De Marchis M. L.

1 Di Rago J. P.

1 Ettorre G. M.

1 Guadagni F.

1 Ialongo C.

1 Kaniak A.

1 Ludovici G.

1 Palmirotta R.

1 Rempola B.

1 Rytka J.

1 Savonarola A.

1 2011

1 2001

Wyniki wyszukiwania

Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion

Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer