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Dolichyl sulphate and H-phosphonate: Enzymatic reactions with activated sugars

100%

Sizova O. V., Maltsev S. D., Shibaev V. N., Jankowski W. J., Chojnacki T.

Acta Biochimica Polonica

1998

tom 45

nr 4

Two phosphate-modified analogues of dolichyl phosphate were evaluated as substrates or inhibitors of the reactions catalyzed by mammalian microsomal enzymes. Dolichyl H-phosphonate could serve as an efficient acceptor for mannosyl and glucosyl transfer. The reaction products were chromatographically different from those formed from dolichyl phosphate. Lower activity of the H-phosphonate was observed for the reaction of N-acetylglucosaminyl phosphate transfer from UDP-GlcNAc. Dolichyl sulphate was shown not to serve as a substrate for the transfer of mannosyl (from GDP-Man), glucosyl (from UDP-Glc) or N-acetylglucosaminyl phosphate (from UDP-GlcNAc) residues in the presence of rat liver microsomes. Weak inhibitory properties of this analogue were demonstrated.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Chojnacki T.

1 Jankowski W. J.

1 Maltsev S. D.

1 Shibaev V. N.

1 Sizova O. V.

1 1998

Wyniki wyszukiwania

Dolichyl sulphate and H-phosphonate: Enzymatic reactions with activated sugars