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1

p600 stabilizes microtubules to prevent the aggregation of CaMKIIalpha during photoconductive stimulation

100%
Belzil C., Ramos T., Sanada K., Colicos M. A., Nguyen M. D.
Cellular and Molecular Biology Letters
|
2014
|
tom 19
|
nr 3
The large microtubule-associated/Ca2+-signalling protein p600 (also known as UBR4) is required for hippocampal neuronal survival upon Ca2+ dyshomeostasis induced by glutamate treatment. During this process, p600 prevents aggregation of the Ca2+/calmodulin-dependent kinase IIα (CaMKIIα), a proxy of neuronal death, via direct binding to calmodulin in a microtubuleindependent manner. Using photoconductive stimulation coupled with live imaging of single neurons, we identified a distinct mechanism of prevention of CaMKIIα aggregation by p600. Upon direct depolarization, CaMKIIα translocates to microtubules. In the absence of p600, this translocation is interrupted in favour of a sustained self-aggregation that is prevented by the microtubule-stabilizing drug paclitaxel. Thus, during photoconductive stimulation, p600 prevents the aggregation of CaMKIIα by stabilizing microtubules. The effectiveness of this stabilization for preventing CaMKIIα aggregation during direct depolarization but not during glutamate treatment suggests a model wherein p600 has two modes of action depending on the source of cytosolic Ca2+.
2

Effect of capsaicin and dimethyl sulphoxide [DMSO] on ion transport in isolated skin of frog [Rana esculenta L.]

100%
Kosik- Bogacka D. I., Tyrakowski T.
Folia Biologica
|
2003
|
tom 51
|
nr 1-2
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The effect of abscisic acid and dimethyl sulfoxide and different temperatures on the cryopreservation process of Abies nordmanniana (Steven) Spach embryogenic callus

84%
Nawrot-Chorabik K., Sitko K.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
|
tom 94
|
nr 3
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

A study of pigments associated with cell walls of calli of some Cactaceae species

84%
Lystvan K., Wybraniec S.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
|
tom 94
|
nr 3
5

Apoptosis of HeLa and CaSki cell lines incubated with all-trans retinoid acid

84%
Darmochwal-Kolarz D., Gasowska-Giszczak U., Paduch R., Kolarz B., Wilcinski P., Oleszczuk J., Kwasniewska A.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 4
6

Studies on the nature of genotoxic and cytotoxic effects induced by hydralazine

84%
Marczewska J., Koziorowska J. H.
Acta Biochimica Polonica
|
1997
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tom 44
|
nr 2
The nature of genotoxic and cytotoxic effects induced by hydralazine was analyzed taking into account possible protection of cells by catalase, superoxide dismutase and dimethyl sulfoxide. For the experiments designed to evaluate the influence of scavengers on the genotoxicity expressed as the SOS induction factor the E. coli PQ37 strain was used. The cytotoxic effects were investigated in V3 cells cultured in vitro. The genotoxicity and cytotoxicity of hydralazine were suppressed by catalase in a dose-dependent manner but they were enhanced by superoxide dismutase. No protective effect of dimethyl sulfoxide was observed. Our results indicate that H2O2 plays an essential role in the genotoxicity and cytotoxicity of hydralazine.
7

Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin - new carriers of alkylating elements

84%
Bartulewicz D., Markowska A., Wolczynski S., Dabrowska M., Rozanski A.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 1
A series of netropsin and distamycin analogues was synthesised and investigated by molecular modelling. The lowest-energy conformations of four carbocyclic lexitropsins, potential carriers of alkylating elements, were obtained using the HyperChem 4.0 program, and compared with the DNA-lexitropsin crystal structures from the Brookhaven National Laboratory Protein Data Bank. A method for synthesis of carbocyclic lexitropsins was elaborated, with the use of a nitro group or azobenzene as precursors for the aromatic amino group. The influence of methoxy group in ortho position with respect to amide groups on the activity of the new compounds was investigated. All of the compounds tested showed high antitumour activity in the standard cell line of mammalian tumour MCF-7.
8

Evaluation of effectiveness of the methods for isolation of cell wall polysaccharides during cell elongation in Phaseolus vulgaris seedlings

84%
Chanda S. V.
Acta Physiologiae Plantarum
|
2005
|
tom 27
|
nr 3B
Phaseolus vulgaris seedlings were grown in light with or without chromium. Changes in cell wall components i.e. pectic poly tacchatides and xyloglucan contents were looked into during cell elongation, by two different methods in order to find the most suitable method for isolation of cell wall poly saccharides. The first method was short and easy. It made use of organic solvents for preparation of cell wall components and ammonium oxalate and oxalic acid buffer and high temperature for extracting pectic polysaccharides; 0.7 M and 4.3 M KOH was used for extracting low and high molecular weight xyloglucans respectively. On the other hand, in the second method, cell wall components were fractionated by sequential treatments with different inorganic solvents, chelating agents, sodium lauryl sulphate, etc. KOH (1 M and 4 M) was used for extracting xyloglucans. The advantage of ustng the second method for extracting cell wall polysaccharides especially pectic polysaccharides is discussed.
9

The effects of organic solvents on poly[ADP-ribose] polymerase-1 activity: implications for neurotoxicity

84%
Banasik M., Stedeford T., Strosznajder R. P., Persad A. S., Tanaka S., Ueda K.
Acta Neurobiologiae Experimentalis
|
2004
|
tom 64
|
nr 4
10

Effect of capsaicin and dimethyl sulphoxide [DMSO] on ion transport in colon wall

84%
Kosik-Bogacka D., Banach B., Tyrakowski T.
Journal of Physiology and Pharmacology. Supplement
|
2001
|
tom 52
|
nr 2
11
Content available remote

Dimethyl sulfoxide in a 10percent concentration has no effect on oxidation stress induced by ovalbumin-sinsitization in a guinea-pig model of allergic asthma

67%
Mikolka P., Mokra D., Drgova A., Petras M., Mokry J.
Journal of Physiology and Pharmacology
|
2012
|
tom 63
|
nr 2
12

Cytochrome P450 mRNA expressions along with in vitro differentiation of hepatocyte precursor cells from fetal, young and old rats

67%
Czekaj P., Bryzek A., Czekaj T. M., Koryciak-Komarska H., Wiaderkiewicz A., Plewka D., Sieron A. L.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 1
46-57
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