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Interaction of annexin VI with membranes. Regulation by ATP in vitro

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Bandorowicz-Pikula J., Danieluk M., Wrzosek A., Bus R., Pikula S.

Cellular and Molecular Biology Letters

1998

tom 03

nr 4

Porcine liver annexin VI (AnxVI) has recently been described to bind in vitro ATP. The binding of nucleotide to protein is accompanied by modulation of AnxVI function, such as its' interaction with F-actin and membranes. In the present report, we show that ATP modulates AnxVI-driven aggregation of phosphatidylserine (PS) liposomes. In addition, we provide evidence using circular dichroism (CD) that the interaction of AnxVI with ATP evokes changes in secondary structure of the protein. The functional implications of these changes are also discussed.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Bandorowicz-Pikula J.

1 Bus R.

1 Danieluk M.

1 Pikula S.

1 Wrzosek A.

1 1998

Wyniki wyszukiwania

Interaction of annexin VI with membranes. Regulation by ATP in vitro