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The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an etiologically-diverse pathological condition resulting from the elevation in both ectopic and autonomic secretion of the antidiuretic hormone (ADH) by neoplastic tissue; excessive stimulation of the hypothalamic-pituitary axis, e.g. in pulmonary diseases, central nervous system (CNS) abnormalities, endocrine glands dysfunction or due to the use of some medications; intensification of renal ADH action by certain medications and action of substances chemically-related to vasopressin. The clinical characteristics of the syndrome are comprised of the presence of inadequately concentrated urine, hyponatremia, and hypo-osmolal blood serum, as well as weight gain. To show the variety of its causes and courses the article presents three cases of patients diagnosed with SIADH in the Department of Internal Medicine. In each of them the syndrome of inappropriate antidiuretic hormone secretion manifested in clinical laboratory tests in the form of hyponatremia.
With the use of conventional anatomical dissection, radiography, digital and statistical analysis, morphometry and skeletopy of the pancreas was carried out in 60 human foetuses of both sexes (28 female, 32 male) between the 17th and 40th week of intrauterine life. The material was fixed in a 10% formalin solution. The age of the foetuses was determined by crown-rump (CR) lenght measurement on the basis of the Iffy et al. tables. Photographic documentation was made and then digitally processed in the Computer Image Digital Analysis System. The following parameters were taken into account: the length and width of 3 parts of the pancreas, namely the head, corpus and tail. Additionally, radiograms were made to obtain a projection of the gland on the vertebral column. Development of the pancreas was correlated with the age of the foetuses calculated on the basis of crown-rump (CR) lenght measurements. The correlation coefficient with CR was 0.998 for the pancreas length, 0.709 for the width of the head, 0.703 for the width of the corpus and 0.712 for the width of tail. Gender dimorphism was not found (p > 0.05) with regard to the morphometry of the pancreas. In the material under examination the pancreas did not change its position in relation to the vertebral column. The head projected on the vertebral column in the range Th₁₂–L₂ (most frequently L₁–L₂), the corpus on Th₁₂–L₂ and the tail on Th₁₁.
Glycosylation is a form of post-translational modification of proteins and occurs in every living cell. The carbohydrate chains attached to the proteins serve various functions. There are two main types of protein glycosylation: N-glycosylation and O-glycosylation. In this paper, we describe the O-glycosylation process and currently known congenital disorders of glycosylation associated with defects of protein O-glycosylation. This process takes place in the cis Golgi apparatus after N-glycosylation and folding of the proteins. The O-glycosylation is essential in the biosynthesis of mucins, the formation of proteoglycan core proteins and blood group proteins. Most common forms of O-glycans are the mucin-type glycans. There are more than 20 known disorders related to O-glycosylation disturbances. We review 8 of the following diseases linked to defects in the synthesis of O-xylosylglycans, O-N acetylgalactosaminylglycans, O-xylosyl/N-acetylglycans, O-mannosylglycans, and O-fucosylglycans: multiple exostoses, progeroid variant of Ehlers-Danlos syndrome, progeria, familial tumoral calcinosis, Schneckenbecken dysplasia, Walker-Warburg syndrome, spondylocostal dysostosis type 3, and Peter's plus syndrome. Causes of these diseases include gene mutations and deficiency of proteins (enzymes). Their diagnosis includes syndromic presentation, organ-specific expression and laboratory findings.
A case of diarrhoea in a four-month-old golden retriever is described. On the basis of anamnesis and bacteriological examination, the diagnosis of bacterial enteritis due to Providencia alcalifaciens was reached. Although there are contradictory opinions about the role of this organism as the enteric pathogen, it seems that Providencia alcalifaciens should also be taken into consideration in the routine bacteriological diagnostics of diarrhoea in dogs.
A modified method of glutaraldeyde-osmium tetroxide fixation was adjusted to characterize the ultrastructure of Candida albicans pleomorphic forms, using phase-contrast microscopy, scanning electron microscopy and transmission electron microscopy. &e discovered morphological criteria defining the individual morphotypes are discussed in terms of mycological and histopathological diagnostics of candidiasis. &e relations are discussed between fungal pleomorphism, virulence and susceptibility of di!erent morphotypes to fungicides.
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Infections caused by Borrelia burgdorferi sensu lato

75%
It is justified to systematically monitor the number of those infected with Lyme disease in European countries and conduct the research on spreading of genospecies B. burgdorferi s.l. in animal reservoirs and vectors. Moreover, it is essential to take action for increasing the society’s awareness of tick-borne diseases prophylaxis. It is very important due to the observed increase in the number and activeness of ticks which leads to the increased risk of infection with spirochetes Borrelia burgdorferi sensu lato and other pathogens transmitted by these vectors.
Introduction. Despite a wide range of imaging modalities available today, clinically silent osteolytic changes in the skeletal system occurring in children are still a diagnostic challenge. Case report. The study presents the case of 10-year-old girl with a tumour in a thoracic vertebra. The patient was admitted to the Paediatric Orthopedics Clinic in the Paediatric Clinical Hospital in Lublin suffering from severe pain in the thoracic and lumbar spine. The pain had started suddenly. Physical examination showed lumbar spine pain and a forced scoliotic position. To reduce the symptoms, spinal traction, analgetics and myorelaxing drugs were used. X-ray and CT of the spine showed congenital unfused S1-S3 vertebrae. An MRI was scheduled for further diagnosis. After treatment, the symptoms disappeared and the the patient was discharged after 6 days. MRI showed an oval, well-demarcated lesion in the vertebra body and left side of the arch of the Th10 vertebra. The patient was admitted to the Clinic one again. CT scan of the thoracic spine showed an osteolytic lesion in Th10 vertebra. In the spine X-ray irregular vertebral body contour in Th10 vertebra, was seen. There were no signs of neoplastic infiltration. Scintigraphy showed increased radioisotope uptake in spinal processes of Th10 and Th11 vertebrae, which confirmed the MRI results. A transpendicular trepanobiopsy of the Th10 vertebrae was performed to provide material for histopathological examination. Then, a transpedicular stabilization of Th9-Th11 vertebrae and posterior sponylodesis with spinal autografts was performed. Histopathological examination showed no malignant cells but did not help to establish a diagnosis. Conclusion. In spite of using all the available diagnostic methods it was impossible to determine the type of lesion in the patient’s spine. Genetic tumour marker test can be considered.
The aim of this study was to analyze data collected by the SENTINEL influenza surveillance system in Poland in the first post-pandemic season 2010/2011. The results include weeks 35/2010–17/2011. Physicians registered weekly number of influenza-like illnesses and collected specimens. Laboratory tests were done using PCR and/or real-time PCR or immunofluorescence. Laboratories also isolated the influenza virus. Influenza-like illness incidence amounted to 2802.7/100000. Weekly incidence ranged from 11.3/100000 to 232/100000. The most affected group was children 0–4 years. Influenza-like illness peak occurred between weeks 02/2011 and 11/2011. Influenza infections were confirmed in 34.9% of specimens. More cases were caused by influenza A, including A(H1N1)pdm09 than influenza B (59.9% vs. 40.1%). The isolated strains were similar to A/California/7/2009 or B/Brisbane/60/2008. Season 2010/2011 in Poland did not differ from the rest of Europe. Further improvement is necessary, especially in the area of specimen collection at the beginning of an epidemic season and carrying out the isolation of the influenza virus.
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