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Effect of bergenin on the kidney of C57BL/6J mice with high fat-diet induced oxidative stress

100%

Sagadevan A., Ramalingam S.

International Letters of Natural Sciences

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2016

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tom 54

The present study evaluated the protective effect of bergenin on high fat diet (HFD) induced diabetic mice. C57BL/6J mice were segregated in two groups, one fed standard diet (NC) and the other fed HFD for 16 weeks. Mice were fed continuously with high fat diet for 16 weeks and subjected to intragastric administration of bergenin (10, 20 and 40 mg/kg body weight (BW)), metformin (25 mg/kg BW) 9 to 16 weeks. At the end of the treatment nephritic markers, lipid peroxidation product, antioxidant and histopathological examination were carried out to assess the efficacy of the treatment. HFD fed mice showed increased plasma glucose, insulin, altered nephritic markers, antioxidant and histopathological abnormalities. Oral Treatment with bergenin (40 mg/kg BW) showed near normalized levels of plasma glucose, lipid peroxidation product, antioxidants, improved insulin and reduced kidney damage. The effects of bergenin were comparable with standard drug, metformin. These data suggest that bergenin protect kidney from deleterious effect of glucose.

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Plasma cystatin C concentration in non-insulin-dependent diabetes mellitus: relation with nephropathy

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Piwowar A., Knapik-Kordecka M., Buczynska H., Warwas M.

Archivum Immunologiae et Therapiae Experimentalis

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1999

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tom 47

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nr 5

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Strong association between fibronectin accumulation and lowered cathepsin B activity in glomeruli of diabetic rats

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Wyczalkowska-Tomasik A., Bartolomiejczyk I., Gornicka B., Paczek L.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 5

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Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration

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Merline R., Lazaroski S., Babelova A., Tsalastra-Greul W., Pfeilschifter J., Schluter K. D., Gunther A., Iozzo R. V., Schaefer R. M., Schaefer L.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 4

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Galangin protects against oxidative damage and attenuates inflammation and apoptosis via modulation of NF-kappaB p65 and caspase-3 signaling molecules in a rat model of diabetic nephropathy

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Aladaileh S. H., Al-Swailmi F. K., Abukhalil M. H., Shalayel M. H.

Journal of Physiology and Pharmacology

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2021

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tom 72

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nr 1

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Analiza zaleznosci miedzy sposobem zywienia a nasileniem poczucia wplywu na przebieg choroby u osob z nefropatia cukrzycowa

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Pietraczyk K., Kozlowska L.

Bromatologia i Chemia Toksykologiczna

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2008

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tom 41

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nr 3