Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: degenerative disc disease

Sortuj według:

Ogranicz wyniki do:

Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes

100%

Gorensek M., Joksimovic C., Kregar-Velikonja N., Gorensek M., Knezevic M., Jeras M., Pavlovcic V., Cor A.

Cellular and Molecular Biology Letters

2004

tom 09

nr 2

Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of ageing, is one of the major causes of low back pain. Autologous chondrocyte transplantation (ACT) is an increasingly popular method of addressing pathological disorders of cartilage. The purpose of our study was to determine whether autologous chondrocytes from elastic cartilage could survive and synthesise a cartilage specific matrix in the intervertebral disc of rabbits. Sixteen lumbar intervertebral discs (IVD) of New Zealand White rabbits were analysed. In 6 IVD, the nucleus pulposus was evacuated and replaced with tissue engineered autologous chondrocytes from auricular cartilage. In the second group, only the nucleus pulposus was evacuated from 6 IVD, with no chondrocytes implantation. Four non-operated IVD were used as a control. Six months after the operation, the animals were euthanized and the IVD were analysed histologically. Autologous cartilage implants were well tolerated by the host for up to six months in vivo. There was only hyaline-like cartilage in the place of the nucleus pulposus. We could not detect any elastic fibres in the new cartilage matrix. In IVD from which only the nucleus pulposus was evacuated and no chondrocytes were implanted, just fibrous tissue was found instead of nucleus pulposus. The overall histological analysis of new cartilage produced after implantation in our study confirmed the hypothesis that ACT from auricular cartilage can be implanted into the IVD instead of the nucleus pulposus and that a significant percentage of implanted chondrocytes survive and produce hyaline-like cartilage.

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Non-surgical and surgical treatment of lumbar degenerative disc disease in the course of peripheral neuropathy

84%

Wojcik G., Piskorz J., Ilzecka J., Nalepa D.

Health Problems of Civilization

2015

tom 09

nr 3

The aim of this article is to review current reports pertaining the effects of treating patients with diagnosed degenerative disc disease in the lumbosacral section of the spine. Materials and methods: the method of descriptive analysis was used. The research was conducted on the basis of materials from MEDLINE and EMBASE databases from the last ten years. The cases of patients with sciatic neuritis caused by degenerative disc disease undergoing conservative treatment, and similar group of patients treated surgically, were analysed. Conclusions: Conservative treatment lowers the intensity of pain, but does not improve the functional abilities of the spine. Surgical treatment gives good and quick therapeutic results, but its long-term effects do not seem better than in the case of conservative treatment. Moreover, surgical treatment may result in serious complications. In rare cases the condition results in a severe impairment of motor functions in legs and sphincter paralysis. Such patients should undergo immediate surgical treatment.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Health Problems of Civilization

1 Cor A.

1 Gorensek M.

1 Ilzecka J.

1 Jeras M.

1 Joksimovic C.

1 Knezevic M.

1 Kregar-Velikonja N.

1 Nalepa D.

1 Pavlovcic V.

1 Piskorz J.

1 Wojcik G.

1 2015

1 2004

Wyniki wyszukiwania

Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes

Non-surgical and surgical treatment of lumbar degenerative disc disease in the course of peripheral neuropathy