Wyniki wyszukiwania

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Apoptosis and clonogenic survival in three tumour cell lines exposed to gamma rays or chemical genotoxic agents

100%

Kumala S., Niemiec P., Widel M., Hancock R., Rzeszowska-Wolny J.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 3

We compared the extent to which apoptosis is induced and clonogenicity reduced in three tumour cell lines - the human melanoma Me45 and promyelocytic leukaemia HL-60, and the rat rhabdomyosarcoma R1 - after exposure to the anticancer drugs etoposide and cis-platinum or to gamma radiation; each induces different types of DNA damage. Cells which readily underwent apoptosis did not necessarily show a correlated loss of clonogenicity; for example, Me45 cells showed the highest sensitivity to all three agents in clonogenic assays but much lower levels of apoptotic cells than R1 or HL-60 cells. These results show that the efficiency of the eradication of clonogenic cells by genotoxic agents does not solely depend on the induction of apoptotic processes, and suggest that the induction of apoptosis and suppression of clonogenicity are independent processes.

2

Comparison of the functional activities of two different preparations of human recombinant tumor necrosis factor alpha

100%

Zeman K., Paleolog E. M., Tchorzewski H., Szymanska B.

Archivum Immunologiae et Therapiae Experimentalis

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1993

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tom 41

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nr 2

3

Antisense oligonucleotides against inducible nitric oxide synthase reduce NO production in RAW 264.7 cells

100%

Bilecki W., Okruszek A., Kwinkowski M., Sanak M., Przewlocki R.

Biotechnologia

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1996

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nr 4

4

Topoisomerase II as a target for anticancer chemotherapy

100%

Kaufmann S. H., Hancock R.

Acta Biochimica Polonica

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1995

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tom 42

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nr 4

Type II DNA topoisomerases are required for the segregation of genomic DNA at cell division in prokaryotic and eukaryotic cells, and inhibitors of these enzymes are potential cytotoxic agents in both prokaryotes and eukaryotes. The bacterial member of the topoisomerase II family, DNA gyrase, and the chemotherapeutic agents which target it are the subject of a recent review (Maxwell, A. et al., 1993, in Molecular Biology of DNA Topoisomerases, Andoh, T. et al., eds.,pp. 21-30, CRC Press, Boca Raton). Here we present an overview of current knowledge of eukaryotic topoisomerase II and the anticancer agents which target this enzyme, focussing predominantly on new observations and recent reports and reviews.

5

Changes of U937 cell viability induced by stress factors - possible role of calmodulin

80%

Wojcik-Piotrowicz K., Kaszuba-Zwoinska J., Rokita E., Nowak B., Thor P.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 4

6

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Characterization of antichemotactic factor extracted from the gastric mucosa of rats

80%

Fujita H., Takahashi S., Okabe S.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 4

Ograniczanie wyników

Apoptosis and clonogenic survival in three tumour cell lines exposed to gamma rays or chemical genotoxic agents

Comparison of the functional activities of two different preparations of human recombinant tumor necrosis factor alpha

Antisense oligonucleotides against inducible nitric oxide synthase reduce NO production in RAW 264.7 cells

Topoisomerase II as a target for anticancer chemotherapy

Changes of U937 cell viability induced by stress factors - possible role of calmodulin

Characterization of antichemotactic factor extracted from the gastric mucosa of rats