Wyniki wyszukiwania

1

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

100%

Holma R., Salmenpera P., Virtanen I., Vapaatalo H., Korpela R.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 3

Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor antagonist montelukast on a mild colitis model in rats. Colitis was induced by administrating 4% dextran sulphate sodium (DSS, MW 45 000) in drinking water for 9 days. Montelukast (10 mg/kg/day) or vehicle was given by gastric gavage once daily simultaneously with DSS administration. A healthy control group receiving water as drinking fluid and vehicle by gastric gavage was included. Body weight loss, consistency of faeces (loose/diarrhoea) and occult blood in the faeces/ gross bleeding were assessed on days 6 - 9. After sacrifice, the following were assessed: colonic histology, the expression of inducible nitric oxide synthase, macrophage/monocyte marker ED1, cyclooxygenase-1 and cyclooxygenase-2, as well as the production of leukotriene B4 and E4, prostaglandin E2, its metabolite bicyclic-prostaglandin E2 and thromboxane B2 in the colonic tissue incubation in vitro. Rats receiving DSS exhibited bloody diarrhoea from day 6 onwards. Montelukast significantly reduced the occult blood in the faeces/ gross bleeding, maintained normal body weight gain and tended to decrease the ratio of leukotriene B4/ prostaglandin E2 production in the colon in vitro. The results indicate that montelukast has some potential to ameliorate mild experimental colitis induced by DSS.

2

Cysteinyl leukotrienes predominantly mediate cisplatin-induced acute renal damage in male rats

84%

Hashim A. A., Helmy M. M., Mouneir S. M.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 5

3

Increased cys-leukotrienes in exhaled breath condensate and decrease of PNIF after intranasal allergen challenge support the recognition of allergic rhinitis in children

84%

Zagorska W., Grzela K., Kulus M., Sobczynski M., Grzela T.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 4

4

The role of leukotrienes in the pathogenesis of systemic sclerosis

84%

Chwiesko-Minarowska S., Kowal K., Bielecki M., Kowal-Bielecka O.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 2

5

Effect of aspirin on cysteinyl leukotrienes production by eosinophils co-cultured with epithelial cells

84%

Jawien J., Olszanecki R., Lorkowska B., Korbut R.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 4

Eosinophils have long been considered to play solely crucial role in the pathogenesis of aspirin-induced asthma, however increasing evidence suggest that the bronchial epithelium is also involved in the initiation and maintenance of allergic inflammation. Epithelial cells and eosinophils retained within airways interact reciprocally to mount and sustain inflammatory response. Recently, we have shown that eosinophil-epithelial cell interactions are capable of amplifying the production of cysteinyl leukotrienes (Cys-LTs). The aim of this study was to investigate if there is any influence of aspirin (ASA) on Cys-LTs and prostaglandin E2 (PGE2) production in the model of co-cultured human epithelial cells (line BEAS-2B) and human eosinophils. Synthesis of Cys-LTs in eosinophils was increased after incubation with ASA. At the same time the production of PGE2 was decreased by aspirin (n=32). BEAS-2B cells barely formed Cys-LTs; addition of ASA increased this production, while production of PGE2 was inhibited by aspirin (n=32). Synthesis of Cys-LTs by eosinophils co-incubated with BEAS-2B was nearly 7-fold higher than that of activated eosinophils alone (1631.5 pg/ml ± 154 vs. 258 pg/ml ± 31; p<0.05; n=32). Surprisingly, in the eosinophil-epithelial cell co-culture, aspirin inhibited both augmentation of Cys-LTs synthesis (from 1631.5 pg/ml ± 154 to 1458 pg/ml ± 137; p<0.05; n=32) and the production of PGE2 (from 2640 pg/ml ± 231 to 319 pg/ml ± 27; p<0.05; n=32). In summary, we have demonstrated that interactions between non-atopic eosinophils and epithelial cells result in augmentation of Cys-LTs production, and this augmentation could be inhibited by aspirin.

6

Functional eicosanoid test and typing [FET] in acetylsalicylic acid intolerant patients with urticaria

67%

Velten F. W., Bayerl C., Baenkler H.-W., Schaefer D.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 12

35-46

One of the common side effects of acetylsalicylic acid (ASA) is the induction of pseudoallergic reactions that range from urticarial wheals to anaphylactic shock. At present there is no reliable detection method available for the diagnosis of ASA-hypersensitivity and its relation to clinical symptoms. The purpose of the present study was to evaluate the functional eicosanoid typing (FET) score taking into account several parameters of the equilibrium between prostaglandins (PG) and peptido-leukotriens (pLT). A total eicosanoid pattern score (TEP) ranging from 0.0 to 3.0, was defined that exhibited significant differences (p 0.001) between ASA-intolerant patients and healthy subjects. In addition to the differentiation of both groups at a TEP cut-off value of 1.0, the increasing TEP values correlated with an increasing severity of clinical symptoms in ASA-intolerant patients. We conclude that the FET has the potential for the safe and reliable detection of ASA-intolerance and, probably, other eicosanoid-related pseudoallergic reactions.

7

The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis

67%

Raithel M., Zopf Y., Kimpel S., Naegel A., Molderings G. J., Buchwald F., Schultis H. W., Kressel J., Hahn E. G., Konturek P.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 4

8

The effect of montelukast on atherogenesis in APOE-LDLR-double knockout mice

67%

Jawien J., Gajda M., Wolkow P., Zuranska J., Olszanecki R., Korbut R.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 3

633-639

We have shown that inhibitors of five lipoxygenase activating protein (FLAP) - MK-886 and BAYx1005 inhibit atherosclerosis in apolipoprotein E / LDL receptor - double knockout mice. We, therefore, investigated whether cysteinyl leukotrienes receptor inhibitor - montelukast, given at a dose of 0.125 µg per 100 mg of body weight per day during 16 weeks, could also attenuate atherogenesis. In apoE/LDLR - DKO mouse model montelukast significantly decreased atherogenesis, measured both by "en face" method (25.5±2.% vs. 17.23 ± 1.8%) and "cross-section" method (455 494 ± 26 477 µm2 vs. 299 201 ± 20 373 µm2). The results were, however, less pronounced, comparing to FLAP inhibitors. This is the first report showing the effect of montelukast on atherogenesis in gene-targeted mice.

Ograniczanie wyników

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

Cysteinyl leukotrienes predominantly mediate cisplatin-induced acute renal damage in male rats

Increased cys-leukotrienes in exhaled breath condensate and decrease of PNIF after intranasal allergen challenge support the recognition of allergic rhinitis in children

The role of leukotrienes in the pathogenesis of systemic sclerosis

Effect of aspirin on cysteinyl leukotrienes production by eosinophils co-cultured with epithelial cells

Functional eicosanoid test and typing [FET] in acetylsalicylic acid intolerant patients with urticaria

The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis

The effect of montelukast on atherogenesis in APOE-LDLR-double knockout mice