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Platinum accumulation and DNA-protein cross-linking in the bacterial cells sensitive and resistant to cis-diamminedichloroplatinum (II)

100%

Zastawny T. H., Olinski R.

Applied Biology Communications. Lublin Scientific Center

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1991

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tom 01

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nr 3

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Effect of hydroxyl functionality of branched polyol component on PUR curing thermal effect

100%

Maminski M.

Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology

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2012

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tom 78

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Cross-linking of nuclear proteins to DNA by platinum compounds

100%

Walter Z., Wozniak K., Kowalik J.

Cellular and Molecular Biology Letters

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1997

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tom 02

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nr 4

In this work we investigated the lymphocyte nuclear proteins which participated in DNA-protein cross-links induced by three platinum compounds: cis-DDP, trans-DDP and carboplatin. Our studies indicated that many proteins were cross- linked to DNA in the intact cell. Trans-DDP was the most effective cross-linker. The cross-linking process depended on time of the cells incubation with aforementioned compounds. Carboplatin produced the DNA-protein cross-links more slowly and less effectively than cis-DDP. After incubation of the cells with cis-DDP, trans- DDP and carboplatin a similar protein pattern was obtained. In case of all compounds studied 34.5 kDa protein was abundantly represented.

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