Wyniki wyszukiwania

1

Reliability of the capsaicin cough reflex sensitivity test in healthy children

100%

Verechova S., Plevkova J., Javorka M., Hanacek J.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 4

365-373

Testing cough reflex sensitivity (CRS) in children requires suitable methodology. A CRS test performed under control of inspiratory flow rate (IFR) shows excellent reliability in children, but it is difficult to perform, especially in younger children. The aim of the present study was to find whether the capsaicin CRS test performed without direct control of constant IFR in healthy children is reliable enough for practical use. The CRS test was performed in 27 healthy children, aged 7-17 yr three times within 8 days. Cough was induced by inhalation of capsaicin aerosol in doubling concentrations (0.61-1250 µmol/l) for 400 ms each. CRS was defined as the lowest capsaicin concentration that evoked 2 or more coughs (C2). Although the intraclass correlation coefficient values showed good to excellent reliability of this test, the within-subject standard deviation values revealed lower reliability of this method compared to the CRS test performed under control of IFR. From the results obtained it is reasonable to conclude that the method using uncontrolled IFR in CRS testing provides acceptable precision only when a bigger sample size is used or more tests are performed. Good to excellent reliability of this method was found in children with higher values of C2 and in those aged 13-17 yr.

2

Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis

84%

Brozmanova M., Plevkova J., Tatar M., Kollarik M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

|

nr 6

153-161

3

Tussigenic agents in the measurement of cough reflex sensitivity

84%

Pecova R., Javorkova N., Kudlicka J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

|

nr 5

4

Cough reflex sensitivity testing in seasonal allergic rhinitis patients and healthy volunteers

84%

Pecova R., Zucha J., Pec M., Neuschlova M., Hanzel P., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2008

|

tom 59

|

nr 6

557-564

5

Cough reflex sensitivity in children with suspected and confirmed gastroesophageal reflux disease

67%

Varechova S., Mikler J., Murgas D., Dragula M., Banovcin P., Hanacek J.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

6

Cough reflex sensitivity in various phenotypes of childhood asthma

67%

Jesenak M., Babusikova E., Petrikova M., Turcan T., Rennerova Z., Michnova Z., Havlicekova Z., Villa M. P., Banovcin P.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

|

nr 5

7

The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1

67%

Varechova S., Durdik P., Cervenkova V., Ciljakova M., Banovcin P., Hanacek J.

Journal of Physiology and Pharmacology. Supplement

|

2007

|

tom 58

|

nr 5

8

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

67%

Varechova S., Plevkova J., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

719-726

9

Changes of cough reflex sensitivity induced by cancer radiotherapy of chest and neck regions

67%

Javorkova N., Hajtmanova E., Kostkova L., Zamecnik L., Pecova R., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 4

157-163

It is reasonable to suppose that airway mucosa can be damaged by irradiation applied to chest and neck regions. The inflammatory process is a consequence of an injury. Airway inflammation is one mechanism responsible for cough induction. So, one can suppose that radiotherapy (RT) focused on the patients' chest or neck may injure airway mucosa, which might change sensitivity of the nerve-endings mediating the cough reflex. The purpose of this study was to examine cough reflex sensitivity (CRS) in patients who underwent RT in the chest and neck regions. CRS test using capsaicin was performed in patients with breast cancer (Group A, n=19), and with lung or neck cancer in (Group B, n=14) who underwent RT. Capsaicin aerosol in doubled concentrations (0.49-1000 µM) was inhaled by a single breath. CRS was defined as the lowest capsaicin concentration that evoked 2 or more coughs (C2). Radiation doses ranged from 40 to 70 Gy. Capsaicin cough challenge was performed before and then in the 2nd and 5th week of RT. We observed a significantly reduced value of C2, i.e., increased cough reflex sensitivity, in Group B in the 2nd week of RT (P= 0.04). We conclude that CRS in the lung or neck cancer patients undergoing RT is significantly enhanced, which could result from injury to the nerve endings in airway mucosa.

Ograniczanie wyników

Reliability of the capsaicin cough reflex sensitivity test in healthy children

Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis

Tussigenic agents in the measurement of cough reflex sensitivity

Cough reflex sensitivity testing in seasonal allergic rhinitis patients and healthy volunteers

Cough reflex sensitivity in children with suspected and confirmed gastroesophageal reflux disease

Cough reflex sensitivity in various phenotypes of childhood asthma

The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

Changes of cough reflex sensitivity induced by cancer radiotherapy of chest and neck regions