Wyniki wyszukiwania

1

Investigations on the secretion mechanism of corticosteroid hormones

100%

Nussdorfer G. G.

Folia Histochemica et Cytobiologica

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1984

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tom 22

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nr 3-4

2

Nanoparticles for targeted delivery of anticancer agents

100%

Storm G., Molema G., Woodle M., Metselaar B., Schiffelers R.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.

3

Corticosteroid-binding globulin in serum of western sitatunga [Tragelaphus spekii]

100%

Siwek M., Nowak K. W., Smielowski J.

Acta Biochimica Polonica

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1994

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tom 41

|

nr 2

4

Safety and efficacy of intravenous cyclophosphamide pulse therapy in therapy refractory Crohn's disease patients

75%

Hirschmann S., Atreya R., Englbrecht M., Neurath M. F.

Journal of Physiology and Pharmacology

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2017

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tom 68

|

nr 1

5

Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD

75%

Van Overveld F. J., Demkow U., Gorecka D., De Backer W. A., Zielinski J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

273-282

Inhaled corticosteroids have a high level of topical anti-inflammatory activity. However, in patients with COPD these drugs have been reported to exert limited effects. A reduction in histone deacetylase (HDAC) activity is suggested to prevent the anti-inflammatory action of corticosteroids. Cigarette smoke is known to reduce HDAC expression. The aim of this study is to compare the outcome of corticosteroid therapy in both smoking and non-smoking COPD patients. Twenty-three smoking patients and 18 ex-smoking patients with COPD were treated with inhaled corticosteroids for a period of 2 months. Blood and induced sputum samples were collected before and after treatment. Values of FEV1 %-predicted did not change upon the therapy, but there was a trend to improve in the ex-smokers (63.1 64.8%-pred.), compared with a decrease in the smokers (63.3 61.6%-pred.). The levels of the pro-inflammatory cytokine IL-8 increased in the group of smokers from 379 ±78 to 526 ±118 ng/ml. Although not significant, a slight decrease from 382 ±70 to 342 ±62 ng/ml was observed in the group of ex-smokers. The neutrophil related elastase activity showed similar effects after steroid treatment, it went up from 36.4 ±12.0 to 113.5 ±9.7 nmol/l in smokers, and decreased from 346.2 ±72.1 to 131.1 ±6.5 nmol/l in ex-smokers with COPD. These results support the evidence that inhaled corticosteroids have no anti-inflammatory effects in COPD patients, but only when these patients are still smoking. Smoking cessation seems the best therapy for COPD patients.

6

New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine

75%

Van Overveld F. J., Demkow U., Gorecka D., De Backer W. A., Zielinski J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

135-142

Inhaled corticosteroids (ICS) are widely used for the treatment of COPD despite of controversial statements concerning their efficacy. The use of N-acetylcysteine (NAC), a mucolytic drug with antioxidant properties, is less clear, but it may counteract the oxidant-antioxidant imbalance in COPD. The aim of this study was to evaluate whether treatment of COPD patients with ICS or NAC is able to improve inflammatory indices and to enhance lung function. ICS treatment enhanced protective markers for oxidative stress such as glutathione peroxidase (GPx) (51.2 ±5.8 vs. 62.2 ±8.6 U/g Hb, P<0.02) and trolox-equivalent antioxidant capacity (TEAC) (1.44 ±0.05 vs. 1.52 ±0.06 mM, P<0.05). NAC decreased sputum eosinophil cationic protein (318 ±73 vs. 163 ±30 ng/ml, P<0.01) and sputum IL-8 (429 ±80 vs. 347 ±70 ng/ml, P<0.05). The increased antioxidant capacity prevented an up-regulation of adhesion molecules, since the levels of intracellular adhesion molecule 1 (ICAM-1) correlated negatively with GPx (P<0.0001) and TEAC (P<0.0001). On the other hand, expression of adhesion molecules was promoted by inflammation, reflected by a positive correlation between the levels of IL-8 and ICAM-1 (P<0.0001). The effects of treatment on lung function were only reflected in the FEV1 values. The absolute value of FEV1, both before and after salbutamol inhalation, increased from 1690 ±98 to 1764 ±110 ml, and 1818 ±106 to 1906 ±116 ml, respectively, after ICS (P<0.05) . Ten weeks after treatment, FEV1 values dropped to 1716 ±120 ml post-salbutamol (P<0.05). When followed by treatment with NAC, these values decreased even further to 1666 ±84 ml. These results suggest that ICS improved lung function in COPD patients with moderate airflow obstruction, beside a minor improvement in the oxidant-antioxidant imbalance leading to a lesser expression of ICAM-1. Treatment with NAC decreased some inflammatory parameters and had indirectly an inhibitory effect on the expression of adhesion molecules.

7

Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience

75%

Brozmanova M., Calkovsky V., Plevkova J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

|

nr 3

23-30

Allergic rhinitis is a common cause of chronic cough. Topical corticosteroids are regarded as the most effective first-time treatment in allergic rhinitis. In this study we evaluated the cough sensitivity during the early and late allergic responses in guinea pigs with experimental allergic rhinitis. Another aim of the study was to follow up the effect of inhaled beclomethasone dipropionate on the cough in guinea pigs with allergic rhinitis. 31 guinea pigs were sensitized with ovalbumin (OA). Animals were intranasally challenged with OA (experiment) or saline (control) in 7-day intervals for 9 weeks. Cough was induced by inhalation of citric acid aerosols in gradually increasing concentrations for 30 s and was evaluated 1 h after the 8th nasal challenge (NCH) and 17 h after the 9th NCH. Cough was significantly increased only during an early allergic response, 1 h after repeated NCH [18 (14-23) vs. 8 (3-10); P<0.001]. Five experimental animals were inhaling aerosol of beclomethasone dipropionate seven days between the 8th and the 9th NCH and cough was evaluated 1 h after the 9th NCH. Inhaled corticosteroids significantly inhibited the enhanced allergic rhinitis related cough [4 (1-9) vs.19 (9-37) vs. 6 (3-9); P<0.05].

8

High efficacy of methotrexate in patients with recurrent idiopathic acute anterior uveitis: a prospective study

75%

Bachta A., Kisiel B., Tlustochowicz M., Raczkiewicz A., Rekas M., Tlustochowicz W.

Archivum Immunologiae et Therapiae Experimentalis

|

2017

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tom 65

|

nr 1

9

Adrenal hormones and the regulation of acute phase protein synthesis

75%

Boers W., Smit R. A., Sala M., Maas A., Chamuleau R. A. F. M.

Folia Histochemica et Cytobiologica

|

1992

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tom 30

|

nr 4

10

Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavage model of acute lung injury

63%

Mokra D., Kosutova P., Balentova S., Adamkov M., Mikolka P., Mokry J., Antosova M., Calkovska A.

Journal of Physiology and Pharmacology

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2016

|

tom 67

|

nr 6

11

Systemic treatment for severe atopic dermatitis

63%

Giavina-Bianchi M., Giavina-Bianchi P.

Archivum Immunologiae et Therapiae Experimentalis

|

2019

|

tom 67

|

nr 2

12

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Using of corticosteroids in small animals ophthalmology

63%

Trbolova A.

Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii

|

2014

|

nr 1

13

Are we right to consider mesenchymal stem cells to be a new perspective for patients with juvenile idiopathic arthritis?

63%

Orczyk K., Smolewska E.

Archivum Immunologiae et Therapiae Experimentalis

|

2018

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tom 66

|

nr 4

14

Wegener's granulomatosis - autoimmunity to neutrophil proteinase 3

63%

Watorek E., Boratynska M., Klinger M.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 3

15

Collateral sensitivity to gemcitabine of P-GP and MRP overexpressing human non-small cell lung cancer [NSCLC] cell lines: a possible role of corticosteroids

63%

Bergman A. M., Pinedo H. M., Loves W. J. P., Veerman G., Peters G. J.

Cellular and Molecular Biology Letters

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1999

|

tom 04

|

nr 3

16

The immunological basis of current and novel therapies of multiple sclerosis

63%

Dubois B., Opdenakker G.

Archivum Immunologiae et Therapiae Experimentalis

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1999

|

tom 47

|

nr 1

17

Treatment of autoimmune disease: time for a paradigm shift?

63%

Mor F.

Archivum Immunologiae et Therapiae Experimentalis

|

2007

|

tom 55

|

nr 1

18

Eosinophil cationic protein in serum of corticosteroid-sensitive and resistant bronchial asthma

63%

Patkowski J., Wytrychowski K., Medrala W.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

|

nr 2-3

19

Treatment of Churg-Strauss syndrome with an inhaled corticosteroid after oral steroids discontinuation due to side effects

51%

Swietlik E., Doboszynska A.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

689-695

20

Intratracheally administrated corticosteroids improve lung function in meconium instilled rabbits

51%

Mokra D., Mokry J., Drgova A., Petraskova M., Bulikova J., Calkovska A.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

Ograniczanie wyników

Investigations on the secretion mechanism of corticosteroid hormones

Nanoparticles for targeted delivery of anticancer agents

Corticosteroid-binding globulin in serum of western sitatunga [Tragelaphus spekii]

Safety and efficacy of intravenous cyclophosphamide pulse therapy in therapy refractory Crohn's disease patients

Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD

New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine

Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience

High efficacy of methotrexate in patients with recurrent idiopathic acute anterior uveitis: a prospective study

Adrenal hormones and the regulation of acute phase protein synthesis

Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavage model of acute lung injury

Systemic treatment for severe atopic dermatitis

Using of corticosteroids in small animals ophthalmology

Are we right to consider mesenchymal stem cells to be a new perspective for patients with juvenile idiopathic arthritis?

Wegener's granulomatosis - autoimmunity to neutrophil proteinase 3

Collateral sensitivity to gemcitabine of P-GP and MRP overexpressing human non-small cell lung cancer [NSCLC] cell lines: a possible role of corticosteroids

The immunological basis of current and novel therapies of multiple sclerosis

Treatment of autoimmune disease: time for a paradigm shift?

Eosinophil cationic protein in serum of corticosteroid-sensitive and resistant bronchial asthma

Treatment of Churg-Strauss syndrome with an inhaled corticosteroid after oral steroids discontinuation due to side effects

Intratracheally administrated corticosteroids improve lung function in meconium instilled rabbits