Wyniki wyszukiwania

1

Self-organizing neural network for modelling 3D QSAR of colchicinoids

100%

Polanski J.

Acta Biochimica Polonica

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2000

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tom 47

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nr 1

A novel scheme for modeling 3D QSAR has been developed. A method involving multiple self-organizing neural network adjusted to be analyzed by the PLS (partial least squares) analysis was used to model 3D QSAR of the selected colchicinoids. The model obtained allows the identification of some structural determinants of the biological activity of compounds.

2

The activity of antioxidant enzymes in Arabidopsis thaliana exposed to colchicine and hydrogen peroxide

100%

Drazkiewicz M., Skorzynska-Polit E., Wanke M., Swiezewska E.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

3

Effect of colchicine application on anther culture response in F1 durum x bread wheat hybrids

75%

Tersi M., Xynias I. N., Gouli-Vavdinoudi E., Roupakias D. G.

Acta Biologica Cracoviensia. Series Botanica. Supplement

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2005

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tom 47

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nr 1

4

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Studies on the effect of EMS and colchicine in M1 generation of sesame (Sesamum indicum L.) var. TMV3

75%

Anbarasan K., Rajendran R., Sivalingam D., Chidambaram A. C.

International Letters of Natural Sciences

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2014

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tom 11

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nr 2

Seeds of sesame (Sesamum indicum L), genotypeTMV3 were treated with various concentrations of EMS and Colchicine like 0.2, 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, 1.6, 1.8 and 2.0 % and the LD50 values observed at 1.0 % of EMS and 0.6 % of Colchicine. Based on their LD50 values appreciable concentrations only selected for further study and their effects on various morphological characters such as plant height per plant, number of branches per plant, number of leaves per plant, days to first flowering, number of capsules per plant, number of seeds per capsule and seed yield per plant (g) were measured quantitatively and the results showed that all the characters were consequently or significantly reduced when compared to control and also EMS showed more effective than colchicine.

5

Thyrotropin-releasing hormone modulates vasopressin and oxytocin synthesis and release from the hypothalamo-neurohypophysial system of different age male rats

75%

Ciosek J., Izdebska K.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

63-70

Thyrotropin-releasing hormone (TRH) is engaged in the modulation of the hypothalamo-neurohypophysial system activity. Effects of repeated intravenously injections of TRH in a dose of 100 ng/100 g b.w. on vasopressin (VP) and oxytocin (OT) biosynthesis and release from the hypothalamo-neurohypophysial system was investigated in rats in different age (1-, 3- or 7-months of the life). To estimate the biosynthesis rate of both neurohormones the colchicine procedure was used (the dose of 5 µg/5 µl icv 20 hours before the decapitation). It has been observed that vasopressin synthesis in the hypothalamus increased gradually with maturation of rats, while OT biosynthesis decreased in the same animals. Hypothalamic biosynthesis rate of VP and OT is most effective in youngest rats and declines during the adolescence of animals. Thyrotropin-releasing hormone directly affects VP-ergic and OT-ergic hypothalamic neurons activity and both neurohormones biosynthesis process. This effect, however, is opposed: TRH acts as a stimulator of vasopressin biosynthesis most of all in young male rats and as an inhibitor for oxytocin biosynthesis especially in mature animals.

6

Synaptosomal sodium pump activity depends on microfilament cytoskeleton integrity

75%

Nedvetsky P. I., Mongin A. A.

Acta Neurobiologiae Experimentalis

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1997

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tom 57

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nr 3

7

Mitotic activity as an early symptom of flower evocation in Pharbitis nil Chois

75%

Czaplewska J., Kopcewicz J.

Acta Physiologiae Plantarum

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1994

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tom 16

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nr 1

8

Cellular uptake and cytotoxicity of free and liposome encapsulated colchicine

75%

Kulkarni S. B., Betageri G. V.

Cellular and Molecular Biology Letters

|

1997

|

tom 02

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nr 2

Besides its use in gouty arthritis, colchicine has been found to be useful for anticancer treatment. However, the severe toxicity and low therapeutic index of colchicine limit its therapeutic use. It was hypothesized that toxicity of colchicine can be reduced if it is encapsulated in liposomes. The objective of this study was to determine and compare in vitro cellular uptake and cytotoxicity of colchicine with that of liposome encapsulated colchicine. Colchicine was encapsulated in negatively charged unilamellar liposomes (LUVs). Two cell lines, human macrophages (U-937) and murine myeloma (B-type, P3X63.Ag8.653) cells were used for these investigations. Cells were incubated with colchicine or liposomal colchicine and cellular uptake was determined by means of radioactive labeled colchicine. Cytotoxicity was determined by MTT (3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyltetrazolium bromide) assay. Human macrophages as well as murine myeloma cells showed greater uptake of liposomal colchicine than plain colchicine. However, cytotoxicity of liposomal colchicine to human macrophages was less compared to that of plain colchicine. On the other hand, in the case of murine myeloma cells, cellular uptake as well as cytotoxicity was greater with liposomal colchicine than that with plain colchicine. These results indicate that liposomal encapsulation of colchicine could avoid or reduce its toxicity and improve therapeutic efficacy.

9

Improving growth indices and productivity of phytochemical compounds in lemon balm (Melissa officinalis L.) through induced polyploidy

63%

Talei D., Fotokian M. H.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2020

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tom 101

|

nr 3

10

Assessment and analysis of autopolyploid Grossularia reclinata Mill (= Ribes uva-crispa L. subsp. reclinata (L.) Rchb.) traits

63%

Buchenkow I. E.

Słupskie Prace Biologiczne

|

2014

|

nr 11

11

Analiza kariotypu krzyżowek Solanum tuberosum (L.) forma Fita x Solanum chacoense (Bitt.) oraz Solanum tuberosum (L.) forma Fortuna x Solanum chacoense (Britt.) przed i po działaniu kolchicyny

63%

Pawlak T., Dudzinska-Goralska E., Bijok K.

Zeszyty Naukowe Wydziału Biologii i Nauk o Ziemi. Uniwersytet Gdański. Biologia

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1982

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nr 03

12

Studies on the influence of microtubular inhibitors on the secretory process in secretory cell of the mammary gland

63%

Sporniak M., Perissel B.

Folia Histochemica et Cytobiologica

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1986

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tom 24

|

nr 4

13

Induction of autotetraploidy in dragonhead [Dracocephalum moldavica L.] by colchicine treatment

63%

Omidbaigi R., Yavari S., Hassani M. E., Yavari S.

Journal of Fruit and Ornamental Plant Research

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2010

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tom 18

|

nr 1

23-35

The genome doubling agent colchicine was used effectively to obtain tetraploid plants in dragonhead. Treatment of apical meristem of seedlings was carried out in two stages. The first stage was when the cotyledon leaves emerged. The second stage was when the two true leaves emerged. Six levels of colchicine concentrations: 0, 0.05, 0.1, 0.2, 0.5, and 0.75% were applied in each of these stages. Seedling treatment in the stage of emergence of two true leaves with 0.1% colchicine solution proved to be the most effective in producing autotetraploids. Morphological, cytological and flow cytometry analyses showed the increase of chromosome numbers from 2n=2x=10 to 2n=4x=20. The increase of ploidy levels caused major changes in some morphological and physiological traits and active substances in dragonhead.

14

Obtaining and characterization of tetraploid forms in cucumber - Cucumis sativus L.var. sativus and var. hardwickii Alef.

63%

Mackiewicz H. O., Malepszy S.

Folia Horticulturae

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1996

|

tom 08

|

nr 1

15

The cytoskeleton proteins and LH-regulated steroidogenesis of porcine luteal cells

63%

Gregoraszczuk E. L., Slomczynska M.

Folia Histochemica et Cytobiologica

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1996

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tom 34

|

nr 1

16

The activity of antioxidant enzymes in Arabidopsis thaliana exposed to colchicine and H2O2

63%

Drazkiewicz M., Skorzynska-Polit E., Wanke M., Swiezewska E.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 3

Studies on the possible interference of colchicine and H2O2 with the activity of some antioxidant enzymes were carried out on Arabidopsis thaliana v. Columbia grown in Murashige and Skooge nutrient medium. Measurements of superoxide dismutase (SOD), guaiacol peroxidase (POX), ascorbate peroxidase (APX) and catalase (CAT) activities were conducted spectrophotometrically. In the presence of colchicine, SOD activity increased, while CAT, APX and POX activities decreased. Inhibitory H2O2 effects on the activity of the enzymes were found. Colchicine pre-treatment resulted in an increase in CAT activity and a further increase in SOD activity in plants treated with H2O2.

17

Colchicine treatment in haploids of Cucumis sativus L., fertility and cytological characteristics in doubled haploids and chimeras

63%

Nikolova V., Niemirowicz-Szczytt K.

Journal of Applied Genetics

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1996

|

tom 37A

18

The pineal and oxytocin synthesis

63%

Bojanowska E., Juszczak M., Guzek J. W., Dabrowski R.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 1

19

Influence of colchicine on autodegradation in mouse hepatocytes

63%

Krol T.

Acta Biologica Cracoviensia. Series Zoologia

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1998

|

tom 40

20

The influence of colchicine on water exchange roots in conditions of rehydratation

63%

Volobuyeva O. V., Khokhlova L. P., Fatyhova E. H.

Biological Bulletin of Poznań. Supplement

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1997

|

tom 34

Ograniczanie wyników

Self-organizing neural network for modelling 3D QSAR of colchicinoids

The activity of antioxidant enzymes in Arabidopsis thaliana exposed to colchicine and hydrogen peroxide

Effect of colchicine application on anther culture response in F1 durum x bread wheat hybrids

Studies on the effect of EMS and colchicine in M1 generation of sesame (Sesamum indicum L.) var. TMV3

Thyrotropin-releasing hormone modulates vasopressin and oxytocin synthesis and release from the hypothalamo-neurohypophysial system of different age male rats

Synaptosomal sodium pump activity depends on microfilament cytoskeleton integrity

Mitotic activity as an early symptom of flower evocation in Pharbitis nil Chois

Cellular uptake and cytotoxicity of free and liposome encapsulated colchicine

Improving growth indices and productivity of phytochemical compounds in lemon balm (Melissa officinalis L.) through induced polyploidy

Assessment and analysis of autopolyploid Grossularia reclinata Mill (= Ribes uva-crispa L. subsp. reclinata (L.) Rchb.) traits

Analiza kariotypu krzyżowek Solanum tuberosum (L.) forma Fita x Solanum chacoense (Bitt.) oraz Solanum tuberosum (L.) forma Fortuna x Solanum chacoense (Britt.) przed i po działaniu kolchicyny

Studies on the influence of microtubular inhibitors on the secretory process in secretory cell of the mammary gland

Induction of autotetraploidy in dragonhead [Dracocephalum moldavica L.] by colchicine treatment

Obtaining and characterization of tetraploid forms in cucumber - Cucumis sativus L.var. sativus and var. hardwickii Alef.

The cytoskeleton proteins and LH-regulated steroidogenesis of porcine luteal cells

The activity of antioxidant enzymes in Arabidopsis thaliana exposed to colchicine and H2O2

Colchicine treatment in haploids of Cucumis sativus L., fertility and cytological characteristics in doubled haploids and chimeras

The pineal and oxytocin synthesis

Influence of colchicine on autodegradation in mouse hepatocytes

The influence of colchicine on water exchange roots in conditions of rehydratation