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1

Cocaine- and amphetamine-regulated transcript-like immunoreactivity (CART-LI) in intramural ganglia of porcine urinary bladder trigone

100%
Zacharko-Siembida A., Arciszewski M. B.
Medycyna Weterynaryjna
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2014
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tom 70
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nr 10
Although the expression pattern of cocaine- and amphetamine-regulated transcript (CART) has been studied in several porcine tissues, it is notable that no data are available on CART expression in the lower urinary tract. In order to map and determine the neurochemical code of CART-like immunoreactivity in the intramural ganglia of the porcine urinary bladder trigone, cryostat sections were immunohistochemically double-stained for CART and HuC/D, as well as for substance P (SP), calbindin, somatostatin and pituitary adenylate cyclase-activating peptide (PACAP). In the ganglia of the urinary bladder trigone, immunoreactivity to CART was detected both in numerous nerve fibres and in minor subpopulation of HuC/D-positive neuronal cell bodies (2.7 ± 0.8%). Neither CART-immunoreactive (IR) nerve fibres, nor CART-IR ganglionic neurons showed simultaneous expression of somatostatin, calbindin and SP. In a substantial proportion of CART-IR neurons (but not nerve fibres) co-localization with PACAP was found. This data suggest that CART present in nervous structures of the porcine urinary bladder may have a role in the parasympathetic regulation of several urinary bladder functions.
2
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The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats

100%
Adamczyk P., McCreary A. C., Przegalinski E., Mierzejewski P., Bienkowski P., Filip M.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 3
119-125
Some empirical evidence suggests that the endocannabinoids (eCB) (e.g. anandamide) may play an important role in cocaine addiction. The eCB act as a retrograde messengers activating CB receptors at the presynaptic membrane and are degraded by enzymatic actions of fatty acid amide hydrolase (FAAH). The present study aimed to examine the effect of the FAAH inhibitors, phenylmethylsulphonyl fluoride (PMSF; i.p.) or cyclohexylcarbamic acid 3-carbamoyl biphenyl-3-yl ester (URB597; i.p.) on the cocaine- or food-maintained self-administration as well as on the cocaine-seeking or food-taking behaviors in rats. Male Wistar rats were implanted with a catheter (iv.) and trained to self-administer cocaine (0.5 mg/kg/infusion) on a fixed ratio 5 schedule of reinforcement with a conditioned stimulus (tone+light). After self-administration stabilized, extinction/reinstatement procedures were carried out during which the rats were tested for the response reinstatement induced by cocaine (10 mg/kg, ip) or a cue (light+tone). The food (sweetened milk) self-administration and extinction/reinstatement procedures were conducted in a manner resembling cocaine self-administration. Neither PMSF (30–120 mg/kg) nor URB597 (0.1–3 mg/kg) affected cocaine self-administration. PMSF, 60 mg/kg, significantly reduced cocaine-induced reinstatement and at 120 mg/kg (combined with the challenge dose of cocaine) it evoked behavioral disruption. PMSF (60-120 mg/kg) dose-dependently inhibited cue-induced reinstatement. URB597 (1-3 mg/kg) attenuated both cocaine- and cue-induced drug-seeking behaviors. PMSF (60 mg/kg) decreased food self-administration. Toward reinstatement of food-taking behavior PMSF (60-120 mg/kg) and URB597 (3 mg/kg) showed inhibitory effects. Our results indicate that FAAH inhibitors could be potent modulators of motivational and conditioned aspects of goal-directed behaviors with less prominent effects on consumatory behaviors.
3
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Role of 5-hydroxytryptamine 1B receptors and 5-hydroxytryptamine uptake inhibition in the cocaine-evoked discriminative stimulus effects in rats

100%
Filip M., Nowak E., Papla I., Przegalinski E.
Journal of Physiology and Pharmacology
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2001
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tom 52
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nr 2
4
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Effect of adrenalectomy and corticosterone on cocaine-induced sensitization in rats

100%
Przegalinski E., Filip M., Siwanowicz J., Nowak E.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 2
5
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Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats

100%
Filip M., Antkiewicz-Michaluk L., Zaniewska M., Frankowska M., Golda A., Vetulani J., Przegalinski E.
Journal of Physiology and Pharmacology
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2007
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tom 58
|
nr 4
The efficacy of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), a member of endogenous tetrahydroisoquinolines, in cocaine- and food-maintained responding in self-administration procedures under a fixed ratio 5 schedule of reinforcement as well as in cocaine and food seeking behaviors in male Wistar rats was examined. The effects of 1MeTIQ on cocaine discrimination and on basal locomotor activity were also assessed. In rats trained to self-administered either cocaine (0.5 mg/kg/injection) paired with the cue (light+tone) or food under a fixed ratio 5 schedule of reinforcement, 1MeTIQ (25 - 50 mg/kg) dose-dependently decreased the cocaine-maintained responding, but did not alter the food-maintained responding. 1MeTIQ (25 - 50 mg/kg) decreased the cocaine seeking behavior reinstated by a noncontingent presentation of cocaine (10 mg/kg, i.p.), but altered neither behavior reinstated by a discrete cue (tone+light) nor food-induced reinstatement. In rats trained to discriminate cocaine (10 mg/kg) from saline in water-reinforced fixed ratio 20 task, pretreatment with 1MeTIQ resulted in neither substitution nor significant alterations in the cocaine (1.25 - 10 mg/kg)-induced discriminative stimulus effects. 1MeTIQ (25 - 50 mg/kg) did not produce also a significant changes in basal horizontal activity. In conclusion, our present results outline a significance of exogenously applied 1MeTIQ in attenuating drug-evoked relapses to cocaine as well as the direct rewarding properties of cocaine (that model the cocaine-induced "high"), but not cocaine subjective effects. Moreover, a dissociation between effects of 1MeTIQ on cocaine vs. food-maintained responding was demonstrated.
6
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Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats

100%
Przegalinski E., Filip M., Papla I., Czepiel K.
Journal of Physiology and Pharmacology
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2002
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tom 53
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nr 3
The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bilaterally with cannulae into the accumbens shell or core, and then were locally injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of 5-HT1B receptors). Given alone to any accumbal subregion, GR 55562 (0.1-10 µg/side) or CP 93129 (0.1-10 µg/side) did not change basal locomotor activity. Systemic cocaine (10 mg/kg) significantly increased the locomotor activity of rats. GR 55562 (0.1-10 µg/side), administered intra-accumbens shell prior to cocaine, dose-dependently attenuated the psychostimulant-induced locomotor hyperactivity. Such attenuation was not found in animals which had been injected with GR 55562 into the accumbens core. When injected into the accumbens shell (but not the core) before cocaine, CP 93129 (0.1-10 µg/side) enhanced the locomotor response to cocaine; the maximum effect being observed after 10 µg/side of the agonist. The later enhancement was attenuated after intra-accumbens shell treatment with GR 55562 (1 µg/side). Our findings indicate that cocaine induced hyperlocomotion is modified by 5-HT1B receptor ligands microinjected into the accumbens shell, but not core, this modification consisting in inhibitory and facilitatory effects of the 5-HT1B receptor antagonist (GR 55562) and agonist (CP 93129), respectively. In other words, the present results suggest that the accumbal shell 5-HT1B receptors play a permissive role in the behavioural response to the psychostimulant.
7
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Inflammation- and axotomy-induced changes in cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) nervous structures in the porcine descending colon

84%
Burlinski P. J.
Polish Journal of Veterinary Sciences
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2012
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tom 15
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nr 3
This study reports on changes in CART-like immunoreactive (CART-LI) nerve structures in the porcine descending colon during chemically driven inflammation and after axotomy. The distribution pattern of CART-LI nerve structures was studied using doublelabeling immunofluorescence technique in the circular muscle layer, myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP) and also in the mucosal layer of the porcine descending colon in physiological conditions as well as under pathological factors. In the control animals, CART-LI perikarya have been shown to constitute 5.11% ± 0.64, 4.03% ± 1.17 and 0.05% ± 0.04 in MP, OSP and ISP, respectively. Changes in CART-immunoreactivity depended on the pathological factor and the part of the enteric nervous system (ENS) studied. Numbers of CART-LI perikarya amounted to 2.77% ± 0.64, 2.60% ± 0.36 and 0.26% ± 0.19 during chemically-induced colitis and 3.04% ± 0.88, 2.46% ± 0.8 and 0.43% ± 0.09 after axotomy in MP, OSP and ISP, respectively. Both studied pathological processes also caused an increase in the number of CART-LI nerve fibers in the circular muscle as well as in the mucosal layer.
8

Co-localisation of cocaine- and amphetamine-regulated transcript peptide and vasoactive intestinal polypeptide in the myenteric plexus of the porcine transverse colon

84%
Palus K., Rytel L.
Folia Morphologica
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2013
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tom 72
|
nr 4
Cocaine- and amphetamine-regulated transcript peptide (CART) is a substance, which can play the role of neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract. However knowledge concerning its functions and co-localisation with other neuronal factors is rather scarce. During the present investigation the co-localisation of CART and vasoactive intestinal polypeptide (VIP) in the neurons of meyenteric plexus within the porcine transverse colon was studied using double immunofluorescence technique and semiquantitative arbitrary scale of the frequency of presence CART+/VIP+, CART+/VIP– and CART–/VIP+ neuronal cells. The most often (+++) CART–/VIP+ neurons were encountered, neurons simultaneously immunoreactive to CART and VIP were observed somewhat rarer (++) and only single (+) CART+/VIP– perikarya were visible. The present study reports for the first time on the co-localisation of CART and VIP in myenteric neurons of the porcine transverse colon. (Folia Morphol 2013; 72, 4: 328–332)
9
Content available remote

Dopamine D1-like receptors agonist SKF 38393 increases cFos expression in the paraventricular nucleus of the hypothalamus - impact of acute and chronic cocaine

84%
Chocyk A., Czyrak A., Wedzony K.
Journal of Physiology and Pharmacology
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2008
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tom 59
|
nr 3
425-440
The present study indicates that activation of dopamine D1-like receptors by administration of SKF 38393 leads to dose-dependent (doses: 5, 10 and 20 mg/kg) increases in the expression of cFos proteins in the rat paraventricular nucleus of the hypothalamus (PVN). This effect was abolished by administration of SCH 23390, a dopamine D1-like receptor antagonist (0.5 and 1 mg/kg, given 30 min before SKF 38393 - 10 mg/kg), suggesting that the apparent effect is specific for activation of dopamine D1-like receptors. Expression of cFos after SKF 38393 (10 mg/kg) was observed in some, but not all, CRF-immunoreactive neurons, as well as in small portion of oxytocin- but not vasopressin-immunoreactive neurons (double-immunofluorescence experiments). There were also certain populations of nuclei that showed expression of cFos but did not co-localize with the above markers. We also found that both acute and repeated (once daily for 5 consecutive days) exposure to cocaine (25 mg/kg) attenuated the induction of cFos expression triggered by SKF 38393 when administered 24 hours after single or the last dose of cocaine (25 mg/kg). Attenuation was observed at the same level after single and chronic exposure to cocaine, indicating a rapid functional down-regulation of dopamine D1-like receptors that are resistant to subsequent doses of cocaine. These data provide evidence for the functional role of dopamine D1-like receptors in the PVN and indicate a functional adaptation of dopamine D1-like receptors following a single dose of cocaine without further progression of adaptation or resistance of D1-like receptor-mediated genomic function in the course of repeated cocaine intake.
10
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On the role of serotonin2A-2C receptors in the sensitization to cocaine

84%
Filip M., Nowak E., Papla I.
Journal of Physiology and Pharmacology
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2001
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tom 52
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nr 3
11

Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist

67%
Meert T. F., De Haes P., Aerts N., Clincke G.
Acta Neurobiologiae Experimentalis
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1996
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tom 56
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nr 4
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effects of calcium channel antagonists on the reinforcing properties of morphine, ethanol and cocaine as measured by place conditioning

67%
Biala G., Langwinski R.
Journal of Physiology and Pharmacology
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1996
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tom 47
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nr 3
13

Wplyw narkotykow i etanolu na sprzeganie z glutationem w korze mozgowej czlowieka

51%
Gutowicz M., Siwinska-Ziolkowska A., Baranczyk-Kuzma A.
Bromatologia i Chemia Toksykologiczna
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2004
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tom 37
|
nr 1
59-64
W pracy przedstawiono aktywność transferazy glutationowej i seleno-niezależnej peroksydazy glutationowej oraz poziom zredukowanego glutationu w różnych częściach kory mózgowej człowieka. Badania prowadzono na tkankach otrzymywanych z autopsji osób zmarłych na skutek zatrucia amfetaminą, kokainą i/lub etanolem.
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