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The biceps brachii muscle is present in the anterior aspect of the arm. Its morphological variations have great clinical significance for surgeons, orthopaedic surgeons, anaesthetists, neurologists and anatomists. This study aimed to describe the incidence and morphology of the extra-heads of the biceps brachii muscle. Hundred upper limbs of 50 adult human cadavers (30 men and 20 women) were used in this study after the approval of the medical ethical committee. These cadavers were obtained from the Anatomy Department, Faculty of Medicine, King Abdul-Aziz University. The incidence of anatomical variations of biceps muscle was equal in both male and female cadavers (10%) with predominance of the left side (7%). The 3-headed biceps brachii muscle was noticed in 7% (4% male and 3% female), while the 4-headed biceps was seen in 2 (2%) left limbs, 1 male and 1 female. The third head of the biceps muscle arose from the anteromedial aspect of humerus, between the coracobrachialis insertion and the brachialis origin, in 6% and from middle of the medial border of humerus in 3%. While the fourth head originated from the articular capsule of shoulder joint in 1 (1%) limb and from the coracoid process of scapula in the other limb. The biceps common tendon of insertion received the supernumerary heads in 7% of the limbs. However, the extra-head fused with the long head in 2 (2%) limbs and united with the short head in 1 (1%) limb. The mean of the third head length was 118.8 ± 10.9 in all limbs, where it was 121.8 ± 12.3 in male and 113.5 ± 8.1 in female cadavers. The third head length/arm length ratio was 38.4 ± 2.6 in all, 38.3 ± 3.4 in male and 38.8 ± 1.8 in female cadavers. The length of the extra-head was extremely significant with those of the corresponding limb in all, male and female cadavers (p < 0.0001). Knowledge of the morphological variations of biceps muscle provides better pre-operative evaluation, safe surgical intervention within the arm and better postoperative outcomes. (Folia Morphol 2013; 72, 4: 349–356)
The aim of this paper is to summarise the knowledge about the anatomy, embryology and anthropology of the mandible and the mandibular foramen and also to highlight the most important clinical implications of the current studies regarding anaesthesia performed in the region of the mandible. An electronic journal search was undertaken to identify all the relevant studies published in English. The search included MEDLINE and EMBASE databases and years from 1950 to 2012. The subject search used a combination of controlled vocabulary and free text based on the search strategy for MEDLINE using key words: ‘mandible’, ‘mandibular’, ‘foramen’, ‘anatomy’, ‘embryology’, ‘anthropology’, and ‘mental’. The reference lists of all the relevant studies and existing reviews were screened for additional relevant publications. Basing on relevant manuscripts, this short review about the anatomy, embryology and anthropology of the mandible and the mandibular foramen was written. (Folia Morphol 2013; 71, 4: 285–292)
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Neuro-hormonal control of food intake; basic mechanisms and clinical implications

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Obesity is one of the most common metabolic diseases and the greatest threats of the health because of possibility of numerous complications. In order to design effective drugs or apply the helpful surgical procedure it is essential to understand physiology of appetite control and pathophysiology of obesity. According to the first law of thermodynamics, the energy input in the form of food, equals energy expenditure through exercise, basal metabolism, thermogenesis and fat biosynthesis. The control of body weight actually concerns the control of adipose tissue with the key role of hypothalamus, possessing several neuronal centers such as that in lateral hypothalamic nuclei considered to be "hunger" center and in ventromedial nuclei serving as the "satiety" center. In addition, paraventricular and arcuate hypothalamic nuclei (ARC) are the sites where multiple hormones, released from the gut and adipose tissue, converge to regulate food intake and energy expenditure. There are two distinct types of neurons in ARC that are important in control of food intake; (1) preopiomelanocortin (POMC) neurons activated by anorexigenic hormones and releasing a-melanocyte-stimulating hormone (alpha-MSH) in satiety center and (2) neurons activated by orexigenic peptides such as ghrelin that release the substances including neuropeptide Y (NPY) and Agouti-Related Peptide (AgRP) in hunger center. ARC integrates neural (mostly vagal) and humoral inputs such as enteropeptides including orexigenic (ghrelin and orexins) and anorexigenic peptides (cholecystokinin, polypeptide YY, glucagon-like peptide-1, oxyntomodulin, leptin and others) that exert a physiological role in regulating appetite and satiety. The peripherally (gut, adipose tissue) and centrally expressed modulators of appetitive behavior act through specific receptors in the afferent (mostly vagal) nerves and hypothalamic neurons implicated in adiposity signaling and regulation of food intake.
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Interplay between Helicobacter pylori and the immune system. Clinical implications

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Helicobacter pylori (H. pylori) is a gram-negative bacteria infecting more than 50% of human population. H. pylori selectively colonizes gastric mucosa and represents the major cause of gastroduodenal pathologies, such as gastric ulcer, autoimmune gastritis, gastric cancer and B cell lymphoma of mucosa associated lymphoid tissue (MALT). In this review interplay between H. pylori and both innate and adaptive immune responses is discussed. The second part of this article presents current knowledge about the relationship between H. pylori infection and neoplasia.
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