Wyniki wyszukiwania

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Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers

100%

Majcherczyk J., Kulza M., Senczuk-Przybylowska M., Florek E., Jawien W., Piekoszewski W.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 1

2

Influence of selective inhibitors of phosphodiesterase 3 and 4 on couch and airway reactivity

100%

Mokry J., Mokra D., Nosalova G., Beharkova M., Feherova Z.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

473-482

3

Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT1A and 5-HT2 receptors in rat frontal cortex

100%

Zahorodna A., Hess G.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 3

Using extracellular recording we studied changes in the reactivity of rat frontal cortical slices to the 5-HT1A, 5-HT2 and 5-HT4 receptor agonists, (±)-2-dipropyloamino-8-hydroxy-1,2,3,4-tetrahydronaphtalene hydrobromide (8-OH-DPAT), (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) and zacopride, respectively, induced by an earlier treatment of animals with corticosterone lasting 1 or 3 weeks. Spontaneous bursting activity was recorded in ex vivo slices incubated in a medium devoid of Mg2+ ions and containing picrotoxin (30 µM). Repetitive, but not single, corticosterone administration resulted in an attenuation of the effect of the activation of 5-HT1A receptors and in an enhancement of the effect related to 5-HT2 receptors. The effect of 5-HT4 receptor activation remained unchanged. In separate two sets of experiments rats were treated with corticosterone for 3 weeks and additionally with imipramine or citalopram, beginning on the eighth day of corticosterone administration. In the corticosterone plus imipramine as well as corticosterone plus citalopram groups the effects of 8-OH-DPAT and DOI were not different from control indicating that corticosterone-induced functional modifications in the reactivity of 5-HT1A and 5-HT2 receptors were reversed by antidepressant treatments.

4

Combined chronic treatment with citalopram and lithium does not modify the regional neurochemistry of nitric oxide in rat brain

100%

Wegener G., Bandpey Z., Heiberg I. L., Volke V., Trabace L., Rosenberg R., Harvey B. H.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 3

A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentation strategy. Also inhibitors of nitric oxide synthase (NOS) have been used as an augmentation strategy, while inhibitors of NOS exhibit antidepressant-like properties in various animal models. Therefore, we hypothesized that modulation of NOS may be involved in the long-term effects of antidepressants and lithium, and studied the influence of acute and chronic administration of citalopram, alone or in combination with lithium, on NOS activity in hippocampus, cerebellum, and frontal cortex, by determination of L-citrulline being formed. We found that administration of acute or chronic citalopram (5 mg/kg and 20 mg/kg/24h, respectively) alone or in combination with subchronic lithium (60 mmol/kg chow pellet) did not influence the activity of NOS ex vivo in all regions compared to control. In contrast, high doses of lithium caused a significant decrease in NOS activity in vitro. We conclude that basal conditions are unsuitable for the study of antidepressant effects on NOS, and that the neurochemistry of nitric oxide remains unaltered following chronic citalopram or subchronic lithium under normal physiological conditions.

5

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The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365260, on citalopram-induced decrease of exploratory behaviour in rat

80%

Matto V., Harro J., Allikmets L.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 4

6

The effect of drugs acting on CCK receptors and rat free exploration in the exploration box

80%

Matto V., Harro J., Allikmets L.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 2

Ograniczanie wyników

5 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

2 Allikmets L.

2 Harro J.

2 Matto V.

1 Bandpey Z.

1 Beharkova M.

1 Feherova Z.

1 Florek E.

1 Harvey B. H.

1 Heiberg I. L.

1 Hess G.

1 Jawien W.

1 Kulza M.

1 Majcherczyk J.

1 Mokra D.

1 Mokry J.

1 Nosalova G.

1 Piekoszewski W.

1 Rosenberg R.

1 Senczuk-Przybylowska M.

1 Trabace L.

1 Volke V.

1 Wegener G.

1 Zahorodna A.

1 2012

1 2008

1 2006

1 2004

1 1997

1 1996

Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers

Influence of selective inhibitors of phosphodiesterase 3 and 4 on couch and airway reactivity

Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT1A and 5-HT2 receptors in rat frontal cortex

Combined chronic treatment with citalopram and lithium does not modify the regional neurochemistry of nitric oxide in rat brain

The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365260, on citalopram-induced decrease of exploratory behaviour in rat

The effect of drugs acting on CCK receptors and rat free exploration in the exploration box