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Gastroenteric parasites were found in 118 patients, which made up 1,1 % of the total number of patients. This number included 62 men and 50 women aged 17-74, 41 on average. The most frequent parasite was Giardia intestinalis. It was found in 82 patients, which constituted 0,78% of the total number of patients and 69,5% of patients infected by parasites. Trichuris trichiura was diagnosed in 16 patients, which made up 0,150% of the total number of patients and 13,4% of the cases of parasitoses. Ascariosis and oxyuriosis were observed in 8 and 7 patients, respectively. The most rarely found parasites were Taeniarhynchus saginatus (3 patients) and Strongyloides stercoralis (2). Parasitic diseases were most often concomitant with: cholecystitis (23 patients), and duodenal ulcer (15). The results of biochemical tests most frequently showed abnormal values of haemoglobin (31,3% of all parasitoses), elevated lipase values (28.8%), eosinophilia (22,2%). Hypoacidity was observed in 48,3% of cases and the positive bile culture results in 28,8%.
The effect of eight anthelmintics (Rintal, Fenbesan, Telmin, Banminth, Pyrantel, Nilverm, Levamisol and Bioscardina) on the α- and γ-amylases, trypsin, and lipase from pig's pancreas and gut of Ascaris suum was determined. In extracts from A. suum gut also the maltase, trehalase and saccharase activities were examined. All drugs tested did not influence on the host's α-amylase. Telmin and Bioscardina were inhibitors of γ-amylase, Rintal and Telmin - of trypsin, Fenbesan and Bioscardina - of lipase from pig's pancreas. Among the parasite's enzymes the lipase was the most sensitive. Its activity was decreased (35-60%) by Telmin, Nilverm and both pyrantel derivatives. The activity of maltase and trehalase was reduced by Levamisol and Banminth, that of saccharase by Levamisol. It is concluded that the anthelmintics Levamisol and Banminth seemed the most efficient among the tested drugs because they did not alter the activity of host's enzymes and, showed the inhibitory effect on three of parasite's enzymes.
The study was aimed at evaluation of effectiveness of castor oil and Senna extract in patients with simple chronic constipation. The investigation was carried out on 30 subjects, who were treated with castor oil at different doses and Senna extract using a cross-over design with an interval of three days. In the light of the results obtained we postulate that castor oil is a superior treatment approach than Senna extract in patients with simple chronic constipation.
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