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Systemic circulatory effects of pentagastrin

100%

Pawlik W. W., Gustaw P., Czarnobilski K., Konturek S. J.

Acta Physiologica Polonica

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1987

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tom 38

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nr 5

2

The effect of cholinergic receptors on ionic transport in the skin of a frog Rana esculenta L.

100%

Kosik-Bogacka D., Tyrakowski T.

Zoologica Poloniae

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2001

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tom 46

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nr 1-4

3

Poly(ADP-ribose) polymerase-1 is a novel nuclear target for cholinergic receptor signaling in the hippocampus

86%

Strosznajder R. P., Jesko H., Adamczyk A.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

209-213

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in DNA repair and transcription regulation. The aim of this study was to investigate the role of PARP-1 in muscarinic cholinergic receptor signaling. Our data indicate that activation of muscarinic cholinergic receptors by carbachol (1mM) in the presence of GTPS evoked a significant enhancement of PARP activity in the adult rat hippocampus. Moreover, TMB-8 (10µM), an antagonist of inositol 1, 4, 5 trisphosphate (IP3) receptor prevented the activation of PARP-1, which indicates that IP3 /Ca2+ signaling is involved in this pathway. The diacylglycerol (DAG)-regulated protein kinase C (PKC) inhibitor (GF109203X) (1µM) only slightly enhanced PARP activity in hippocampal nuclear fractions, which suggests that DAG/ PKC is not involved in PARP activation.

4

Increase of cardiodepressant activity in medium incubating the posterior pituitary lobe in situ during vagal nerve stimulation in rat

86%

Goraca A., Traczyk W. Z.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 3

Previous studies have indicated that there is a cardiodepressant factor in the medium incubating the posterior pituitary lobe in situ. The cardiodepressant activity of the medium incubating the posterior pituitary lobe before and during stimulation of the vagus nerves was tested on isolated auricles of the right heart atrium of a two-day-old rat. It was found that the medium incubating the posterior pituitary lobe collected before stimulation decreased the contraction rate of the auricle by 34%, while that collected during the intermittent stimulation of the central ends of the cut vagus nerves caused a decrease of the auricle contractions frequency by 52%. The addition of cholinergic, serotoninergic, histaminergic receptor blockers or prostaglandin synthetase into Ringer-Lock’s solution bathing the auricle has no effect on the changes of the contraction rate caused by the incubation medium.

5

p38 Mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland

72%

Carlsson S. K., Gierow J. P.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 1

The lacrimal gland (LG) is an exocrine gland important for secretion of the tear film. The kinase p38 has important signal transduction functions, e.g. in gene transcription, but has previously not been known to modulate exocrine secretion. The aim of the current study was to investigate the role of p38 in carbachol (Cch)-induced LG secretion in LG acinar cells in vitro. Western blotting was used to determine the phosphorylation status of p38 and p42/44 and determine expression of p38 isoforms. To determine the effect of p38 inhibition on LG secretion, PD 169316, a general p38 inhibitor, and SB 239063, an inhibitor of p38α and β, were added to the cells prior to secretion measurements. The results revealed activation of p38 mediated by Cch stimulation and inhibition of Cch-induced secretion as a result of p38 inhibition. The inhibition was observed with PD 169316 isoforms, but not with SB 239063. The p38δ isoform was shown to have robust expression both by Western blotting of acinar cells and immunofluorescence of the whole gland. In conclusion, p38 activation mediates secretion in cholinergic stimulation of rabbit LG cells.

6

Role of cholinergic receptor subtypes upon the antro-duodenal coordination in sheep

72%

Romanski K. W., Slawuta P.

Journal of Physiology and Pharmacology. Supplement

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2001

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tom 52

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nr 2

7

The effect of selected agonists and antagonists of cholinergic receptors on the motor activity of epithelium of Achatina fulica

58%

Kaczorowski P.

Folia Malacologica

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2016

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tom 24

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nr 1

8

In vitro recorded theta-like activity in the limbic cortex: comparison with spontaneous theta and epileptiform discharges

58%

Konopacki J., Golebiewski H., Eckersdorf B., Kowalczyk T., Bocian R.

Acta Neurobiologiae Experimentalis

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2000

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tom 60

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nr 1

The generation of EEG theta rhythm in the mammalian limbic cortex is a prime example of rhythmic activity that involves central mechanisms of oscillations and synchrony. This EEG pattern has been extensively studied since 1938, when Jung and Kornmuller (1938) demonstrated the first theta recordings in the hippocampal formation of rabbits. In 1986 in collaboration with Drs. B.H. Bland, S.H. Roth and B.M. Maclver we demonstrated for the first time that bath perfusion of hippocampal slices with the cholinergic agonist, carbachol, resulted in theta-like oscillations. Since this initial demonstration of in vitro theta-like activity, we have carried out a number of experiments in an attempt to answer the basic question: what are the similarities between cholinergic-induced in vitro theta-like activity and theta rhythm which naturally occurs in the in vivo preparation. Thus far, our studies have provided strong evidence that theta-like activity recorded in vitro shares many of the physiological and pharmacological properties of theta rhythm observed in vivo. The question whether in vitro theta-like oscillations reflect features of epileptiform activity is also adressed in this review.

9

The neuromodulation aspects of ischaemic myocardium: the importance of cholinergic system

58%

Gajewski M., Moutiris J. A., Maslinski S., Ryzewski J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 2

10

Development of oscillatory activity in the limbic cortex in vitro

51%

Konopacki J.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 1

Ograniczanie wyników

Systemic circulatory effects of pentagastrin

The effect of cholinergic receptors on ionic transport in the skin of a frog Rana esculenta L.

Poly(ADP-ribose) polymerase-1 is a novel nuclear target for cholinergic receptor signaling in the hippocampus

Increase of cardiodepressant activity in medium incubating the posterior pituitary lobe in situ during vagal nerve stimulation in rat

p38 Mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland

Role of cholinergic receptor subtypes upon the antro-duodenal coordination in sheep

The effect of selected agonists and antagonists of cholinergic receptors on the motor activity of epithelium of Achatina fulica

In vitro recorded theta-like activity in the limbic cortex: comparison with spontaneous theta and epileptiform discharges

The neuromodulation aspects of ischaemic myocardium: the importance of cholinergic system

Development of oscillatory activity in the limbic cortex in vitro