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Effect of subdiaphragmatic vagotomy and cholinergic agents in the hypothalamic-pituitary-adrenal axis activity

100%

Bugajski A. J., Zurowski D., Thor P., Gadek-Michalska A.

Journal of Physiology and Pharmacology

2007

tom 58

nr 2

In the present study, we examined whether the vagus nerve is involved in mediating the stimulation of hypothalamic-pituitary-adrenal (HPA) axis by cholinergic muscarinic and nicotinic agonists, carbachol and nicotine. The site of HPA axis muscarinic stimulation was determined using peripheral (i.p.) and intracerebroventricular (i.c.v.) administration of carbachol, atropine sulphate (AtrS) and atropine hydrobromide (AtrBr). The i.p. carbachol-(0.5 mg/kg)-induced corticosterone response was significantly reduced by i.p. pretreatment with AtrBr (0.1 mg/kg), but was not diminished by i.c.v. AtrS (0.1µg). The increase in corticosterone secretion induced by i.c.v. carbachol (2 µg) was totally abolished by i.c.v. pretreatment with AtrS (0.1 µg) but was not altered by i.p. AtrBr. Subdiaphragmatic vagotomy performed 2 weeks earlier substantially decreased the i.p. carbachol (0.2 mg/kg)-induced ACTH response and markedly augmented ACTH and corticosterone response to a higher dose of carbachol (0.5 mg/kg) in comparison with the responses in sham operated rats. Vagotomy abolished the stimulatory effect of i.p. nicotine in a low dose (1 mg/kg) on ACTH and corticosterone secretion; the ACTH response to higher dose (2.5 mg/kg) was considerably reduced, while corticosterone response remained unaffected. These results suggest that carbachol given i.c.v. evokes considerable corticosterone response by stimulation of central cholinergic muscarinic receptors. A major part of the i.p. carbachol-induced corticosterone secretion results from peripheral cholinergic muscarinic receptor stimulation. Subdiaphragmatic vagotomy moderately intensified the carbachol-induced ACTH and corticosterone secretion. Vagotomy significantly reduced the nicotine-induced ACTH secretion, possibly by the involvement of vagal afferents. The nicotine-induced corticosterone secretion is not exclusively regulated by circulating ACTH but by various intra-adrenal regulatory components.

The influence of adrenergic and cholinergic agents on the respiratory burst of human neutrophils from peripheral blood and synovial fluid

58%

Gajewski M., Gujski M., Ksiezopolska-Pietrzak K., Jozwicka M., Maslinski S.

Journal of Physiology and Pharmacology. Supplement

1997

tom 48

nr 2

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

1 Bugajski A. J.

1 Gadek-Michalska A.

1 Gajewski M.

1 Gujski M.

1 Jozwicka M.

1 Ksiezopolska-Pietrzak K.

1 Maslinski S.

1 Thor P.

1 Zurowski D.

1 2007

1 1997

Wyniki wyszukiwania

Effect of subdiaphragmatic vagotomy and cholinergic agents in the hypothalamic-pituitary-adrenal axis activity

The influence of adrenergic and cholinergic agents on the respiratory burst of human neutrophils from peripheral blood and synovial fluid