Wyniki wyszukiwania

1

Clofibrate and di[2-ethylhexyl]phthalate increase ubiquinone contents without affecting cholesterol levels

100%

Aberg F., Appelkvist E. L.

Acta Biochimica Polonica

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1994

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tom 41

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nr 3

Induction studies were performed on liver, muscle, heart, brain and blood by feeding Sprague-Dawley rats a diet containing a peroxisome proliferator, clofibrate or di(2-ethylhexyl)phthalate. Ingestion of these drugs resulted in an increase in the amount of two different types of ubiquinone homologues UQ9 and UQ10 found in rat. Phthalate proved to be the more effective drug, leading to a highly increased amount of ubiquinone in the liver. Increases were also found in all the above-mentioned organs except the brain. The UQ9 levels were raised to 400, 200,120 and 120%, of the respective normal values. The antioxidant and hypolipidemic agent, probucol, was used as a control to evaluate whether the increased ubiquinone level constituted a response to the elevated hydrogen peroxide pressure, resulting from the induced increase in fatly acid 0-oxidation. In the presence of probucol, ubiquinone levels were decreased in all the above-mentioned organs except heart and brain. Probucol had limited effects on the amount of cholesterol and did not significantly alter the amount of dolichol. The two peroxisome proliferators differed in their effects on cholesterol, as well as on dolichol levels which was induced by phthalate but not by clofibrate. The possible mechanisms involved, and the importance of low toxicity drugs which could elevate ubiquinone levels in various tissues, arc discussed.

2

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Influence of the system of rearing on cholesterol level and its fraction in blood serum of slow-growing chickens

88%

Wnuk A., Mroczek-Sosnowska N., Lukasiewicy M., Batorska M., Niemiec J.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

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2013

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tom 52

The experiment was carried out on 936 slow-growing chickens from the crossbreed of Cobb cock with Greenleg Partridge hen. Chicks were randomly divided into two groups: controlled group (BW) with no access to the field and experimental group (W) with access to grass fields since their fourth week of life. In blood serum overall cholesterol, lipoproteins with high density (HDL), triacylglycerols (TG) level was marked. The concentration of lipoproteins with low density was calculated while using the Friedewald et al. formula (1972). No statistically significant influence of sex and system of breeding on cholesterol and its fractions level in blood serum of crossbreed chickens was observed.

3

Effect of protected CLA and linseed on fatty acid profile and cholesterol level in some tissues of fattened lambs

75%

Borowiec F., Furgal K.

Polish Journal of Natural Sciences. Supplement

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2006

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tom 03

165-170

4

Cholesterol levels in relation to physical and social conditions. Studies of a countryside living occupationally active Swedish population

75%

Thelin A., Stjernstrom E. L., Holmberg S.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

5

Acid and neutral lipase activity in lymphocytes of patients with increased serum cholesterol and triglyceride level

75%

Miszczuk-Jamska B., Chevalier F., Maire I., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 4

6

Effect of diet supplemented with black cumin (Nigella sativa) seeds on egg yolk fatty acid profile and egg yolk cholesterol level of Japanese quail (Coturnix japonica)

63%

Szczerbinska D., Sulik M., Majewska D., Ligocki M., Adaszynska-Skwirzynska M.

Acta Scientiarum Polonorum. Zootechnica

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2020

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tom 19

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nr 3

7

Regulation of steroidogenic function of mouse Leydig cells: G-coupled membrane estrogen receptor and peroxisome proliferator-activated receptor partnership

63%

Gorowska-Wojtowicz E., Dutka P., Kudrycka M., Pawlicki P., Milon A., Plachno B. J., Tworzydlo W., Pardyak L., Kaminska A., Hejmej A., Bilinska B., Kotula-Balak M.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 3

8

Mechanizm dzialania fitosteroli w obnizaniu poziomu cholesterolu LDL we krwi

63%

Wlodarek D.

Roczniki Państwowego Zakładu Higieny

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2007

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tom 58

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nr 1

47-51

Spożycie cholesterolu z żywnością w diecie krajów zachodnich osiąga wartości nawet 400 mg dziennie, podczas gdy w rekomendacjach zaleca się, aby ilość ta nie przekraczała 300 mg dziennie, a u osób z chorobami układu krążenia 200 mg dziennie. Działanie obniżające poziom cholesterolu we krwi, przez fitosterole znane jest od 50 lat. Zdolność ta związana jest z mechanizmem hamowania jego wchłaniania w przewodzie pokarmowym. Drugi z możliwych mechanizmów związany jest ze zwrotnym transportem cholesterolu z enterocytów do przewodu pokarmowego z wykorzystaniem białek transportujących ABC. Wyżej opisane mechanizmy działania fitosteroli są odmienne od mechanizmu działania statyn, powszechnie stosowanych w terapii hipercholesterolemii. Stwarza to możliwość stosowania fitosteroli i statyn łącznie w obniżaniu zbyt wysokich poziomów cholesterolu we krwi. Dzięki temu osoby już przyjmujące statyny u których nie uzyskano wartości referencyjnych cholesterolu całkowitego i cholesterolu LDL mogą poprzez włącznie do diety fitosteroli uzyskać ich dodatkowe obniżenie.

9

Effect of dietary plant oils and animal fats on fatty acid profile and blood cholesterol levels in pigs

63%

Hanczakowski P., Szymczyk B., Hanczakowska E.

Polish Journal of Natural Sciences. Supplement

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2006

|

tom 03

321-326

10

The effect of different dietary fibres on volatile fatty acid content of caecum and cholesterol level in rat blood

63%

Furgal-Dzierzuk I., Szymczyk B.

Annals of Animal Science. Supplement

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2003

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nr 2

11

Milk cholesterol levels in relation to calcium soap and copper content in diets for dairy cows

63%

Brzoska F., Sala K.

Journal of Animal and Feed Sciences. Supplement

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2001

|

tom 10

|

nr 2

12

The cholesterol level in muscles of crossbred fatteners slaughtered at different body weights

63%

Migdal W., Borowiec F., Koczanowski J., Klocek C., Mlynek J., Nowicki J., Gardzinska A.

Annals of Animal Science. Supplement

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2001

|

nr 1

13

Efect of nutrition and season on cholesterol level in milk of Holstein-Friesian cows

63%

Krzyzewski J., Strzalkowska N., Jozwik A., Bagnicka E., Ryniewicz Z.

Annals of Animal Science. Supplement

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2003

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nr 2

14

Inhibition of biogenic membrane flippase activity in reconstituted ER proteoliposomes in the presence of low cholesterol levels

51%

Rajasekharan A., Gummadi S. N.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 1

Biogenic membranes or self-synthesizing membranes are the site of synthesis of new lipids such as the endoplasmic reticulum (ER) in eukaryotes. Newly synthesized phospholipids (PLs) at the cytosolic leaflet of ER need to be translocated to the lumen side for membrane biogenesis and this is facilitated by a special class of lipid translocators called biogenic membrane flippase. Even though ER is the major site of cholesterol synthesis, it contains very low amounts of cholesterol, since newly synthesized cholesterol in ER is rapidly transported to other organelles and is highly enriched in plasma membrane. Thus, only low levels of cholesterol are present at the biosynthetic compartment (ER), which results in loose packing of ER lipids. We hypothesize that the prevalence of cholesterol in biogenic membranes might affect the rapid flip-flop. To validate our hypothesis, detergent solubilized ER membranes from both bovine liver and spinach leaves were reconstituted into proteoliposomes with varying mol% of cholesterol. Our results show that (i) with increase in the cholesterol/PL ratio, the half-life time of PL translocation increased, suggesting that cholesterol affects the kinetics of flipping, (ii) flipping activity was completely inhibited in proteoliposomes reconstituted with 1 mol% cholesterol, and (iii) FRAP and DSC experiments revealed that 1 mol% cholesterol did not alter the bilayer properties significantly and that flippase activity inhibition is probably mediated by interaction of cholesterol with the protein.

15

Effect of Baikal skullcap root (Scutellaria baicalensis radix) on cholesterol level and meat quality in rabbits fed a cholesterol rich diet

51%

Kroliczewska B., Mista D., Zawadzki W., Skiba T.

Folia Biologica

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2011

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tom 59

|

nr 3-4

16

Aparat do regulowania i pomiarów wysiłku fizycznego u małych zwierząt laboratoryjnych

51%

Ziombski H., Szczygiel A.

Roczniki Państwowego Zakładu Higieny

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1962

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tom 13

|

nr 6

17

Lipid changes occuring in the course of hematological cancers

51%

Kuliszkiewicz-Janus M., Malecki R., Mohamed A. S.

Cellular and Molecular Biology Letters

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2008

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tom 13

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nr 3

465-474

The relationship between plasma lipid levels and mortality from cardiovascular diseases has been shown in many studies, but there has been far less investigation into their relationship to non-cardiovascular diseases. The aim of this study was to investigate the lipid profile of individuals with hematological malignancies and its relationship to disease activity. 238 patients were included in the study: 84 with acute leukemia, 62 with non-Hodgkin lymphoma, 35 with Hodgkin’s lymphoma, 32 with multiple myeloma, and 25 with myeloproliferative syndrome. The HDL cholesterol level of the patients differed to that of the individuals in the control group in the active disease period for all the analyzed disorders, but only remained statistically significant in the acute leukemia and non-Hodgkin lymphoma groups during the remission period. Smaller differences were observed for the remaining lipid fractions, except for the triglyceride level, which increased in the active disease period in all the analyzed disorders except non-Hodgkin lymphoma. The most pronounced changes in the lipid fractions occurred in the HDL cholesterol level, and were the most remarkable for acute leukemia.

18

Impact of different maintenance conditions on the lipid profile parameters at fox - Alopex lagopus

51%

Nowakowicz-Debek B., Saba L., Bis-Wencel H., Bombik E.

Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica

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2005

|

tom 23

239-244

19

Milk yield, composition and cholesterol level in dairy cows fed rations supplemented with zinc and fatty acid calcium salts

51%

Brzoska F., Kowalczyk J.

Journal of Animal and Feed Sciences

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2002

|

tom 11

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nr 3

20

The effect of feeding sows conjugated linoleic acid [CLA] in late pregnancy on blood thyroid hormone and cholesterol levels in piglets

51%

Pietras M., Barowicz T., Pieszka M.

Journal of Animal and Feed Sciences

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2002

|

tom 11

|

nr 4

Ograniczanie wyników

Clofibrate and di[2-ethylhexyl]phthalate increase ubiquinone contents without affecting cholesterol levels

Influence of the system of rearing on cholesterol level and its fraction in blood serum of slow-growing chickens

Effect of protected CLA and linseed on fatty acid profile and cholesterol level in some tissues of fattened lambs

Cholesterol levels in relation to physical and social conditions. Studies of a countryside living occupationally active Swedish population

Acid and neutral lipase activity in lymphocytes of patients with increased serum cholesterol and triglyceride level

Effect of diet supplemented with black cumin (Nigella sativa) seeds on egg yolk fatty acid profile and egg yolk cholesterol level of Japanese quail (Coturnix japonica)

Regulation of steroidogenic function of mouse Leydig cells: G-coupled membrane estrogen receptor and peroxisome proliferator-activated receptor partnership

Mechanizm dzialania fitosteroli w obnizaniu poziomu cholesterolu LDL we krwi

Effect of dietary plant oils and animal fats on fatty acid profile and blood cholesterol levels in pigs

The effect of different dietary fibres on volatile fatty acid content of caecum and cholesterol level in rat blood

Milk cholesterol levels in relation to calcium soap and copper content in diets for dairy cows

The cholesterol level in muscles of crossbred fatteners slaughtered at different body weights

Efect of nutrition and season on cholesterol level in milk of Holstein-Friesian cows

Inhibition of biogenic membrane flippase activity in reconstituted ER proteoliposomes in the presence of low cholesterol levels