Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: cholesterol biosynthesis

Sortuj według:

Ogranicz wyniki do:

Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin

100%

Slyshenkov V. S., Rakowska M., Wojtczak L.

Acta Biochimica Polonica

1996

tom 43

nr 2

Preincubation of Ehrlich ascites tumour cells with millimolar concentrations of pantothenic acid, pantothenol or pantethine, but not with homopantothenic acid, at 22°C or 32°C, but not at 0°C, makes the plasma membrane more resistant to the damaging effect of submillimoiar concentrations of digitonin. It is proposed that this increased resistance is due to the increased rate of cholesterol biosynthesis. In fact, incorporation of [14C]acetate into cholesterol is by 45% increased in the cells preincubated with pantothenic acid; this probably reflects elevation of the content of CoA in such cells [Slyshenkov, V.S., Rakowska, M., Moiseenok, A.G. & Wojtczak, L. (1995) Free Radical Biol. Med. 19,767-772].

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Rakowska M.

1 Slyshenkov V. S.

1 Wojtczak L.

1 1996

Wyniki wyszukiwania

Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin