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1

Chemosensitivity of a chloroquine-resistant Plasmodium falciparum isolate to quinine - type compounds in vitro

100%
Nair L., Bhasin V. K.
Acta Protozoologica
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1993
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tom 32
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nr 2
2

The effect of blood-cycle synchronicity on the chloroquine sensitivity of Plasmodium chabaudi

100%
Tahar R., Gautret P., Landau I.
Acta Parasitologica
|
1995
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tom 40
|
nr 2
Plasmodium chabaudi, a rodent malaria parasite with a synchronous asexual cycle in the blood, depending on the host’s circadian rhythm, was desynchronized by modifying its normal timing: blood taken from a donor mouse in the morning was kept 8 h at +4°C and inoculated in the evening into naive mice. When the infection had become asynchronous (from day 4 to day 7) mice were treated with a single dose of chloroquine. The efficacy of chloroquine was lower in mice with an asynchronous infection than in the control mice with a normally synchronous infection.
3

Polymorphism of PFCRT and PFMDR-1 genes of Plasmodium falciparum and chloroquine susceptibility in Cote d'Ivoire

84%
Djaman J. A., Bla B. K., Yavo W., Yapi H. F., Mazabraud A., Basco L. K.
Acta Protozoologica
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2007
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tom 46
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nr 4
361-365
4

Low rates of Plasmodium falciparum Pfcrt K76T mutation in three sentinel sites of malaria monitoring in Cote d’Ivoire

84%
Konate A., Gnagne P. A., Bedia-Tanoh V. A., Amiah-Droh M., Tano D. K., Menan H. I. E., Yavo W.
Acta Parasitologica
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2018
|
tom 63
|
nr 4
5

The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and alpha-mangostin with mefloquine/artesunate

84%
Chaijaroenkul W., Na-Bangchang K.
Acta Parasitologica
|
2015
|
tom 60
|
nr 1
6

The effect of metal ions incorporated into dopa-melanin on chloroquine binding ability

84%
Buszman E., Kwasniak B., Wilczok T.
Current Topics in Biophysics
|
1992
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tom 16
|
nr 2
7

Detection of molecular markers for chloroquine and pyrimethamine-sulfadoxine resistance in imported cases of Plasmodium falciparum malaria in Poland

84%
Myjak P., Nahorski W., Szostakowska B., Zarnowska-Prymek H., Pietkiewicz H.
Acta Parasitologica
|
2007
|
tom 52
|
nr 3
The identified mutations in the pfcrt, dhfr and dhps genes of Plasmodium falciparum show a very high correlation with resistance to chloroquine, pyrimethamine and sulfadoxine, the drugs that are still used as malaria chemoprophylaxis or treatment. We undertook a molecular screening of 82 Polish P. falciparum isolates, mainly imported from different countries of sub-Saharan Africa to assess their molecular drug-resistance profiles. Only 4 isolates showed no mutations in the three analyzed gene fragments. In the remaining isolates from one to six mutations in one or more examined genes were found. Different mutations in the pfcrt, dhfr and dhps genes were found in ca. 76%, 80% and 70% of P. falciparum isolates, respectively. About forty our patients used chloroquine or pyrimethamine + sulfadoxine as malaria chemoprophylaxis and/or antimalarial treatment, but without success. In all but 5 of the P. falciparum isolates obtained from these persons, mutations associated to resistance of the parasite to chloroquine and the antifolate drugs were found.
8

Physicochemical properties of melanin isolated from Cladosporium cladosporioides

84%
Buszman E., Wiewiora A., Andrzejczyk J., Wilczok T.
Current Topics in Biophysics
|
1992
|
tom 16
|
nr 2
9
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Polymorphisms of the Pfatpase 6 and Pfcrt gene and their relationship with the in vitro susceptibility to dihydroartemisinin and chloroquine of Plasmodium falciparum isolates from Abobo, Cote d’Ivoire

67%
Bla B. K., Yavo W., Trebissou J., Kipre R. G., Yapi F. H., N'guessan J. D., Djaman J. A.
Annals of Parasitology
|
2014
|
tom 60
|
nr 4
As a result of widespread resistance to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP), artemisinin-based combination therapy (ACT) has been recommended as a first-line anti-malarial regimen in Côte d’Ivoire since 2005. A thorough understanding of the molecular bases of P. falciparum resistance to existing drugs is therefore needed. The aims of this study were to analyze the in vitro sensitivity of P. falciparum field isolates from Abobo to CQ, pyronaridine (PYR) and dihydroartemisinine (DHA), and to investigate the polymorphisms associated with drug resistance. The standard in vitro drug sensitivity microtechnique recommended by the WHO was used to assess the sensitivity of Plasmodium falciparum isolates collected in December 2006. The Pfcrt haplotype 76 was analysed by PCR-RFLP while Pfatpase 6 amplification products were sequenced. Associations between drug sensitivity and parasite gene polymorphisms were evaluated with Cohen’s kappa test. The correlation between the IC50 values for different drugs was assessed by the coefficient of determination (r2). Significance was assumed at p<0.05. Of 128 in vitro tests performed, 112 (87.5%) were successful. Of the isolates, 56.2% were resistant for CQ and 48% for PYR. One isolate (3.6%) demonstrated reduced DHA sensitivity (IC50 higher than 10 nM). The mutant K76T pfcrt codon, present in 90% of DNA fragments analyzed, was associated with CQ-R (ĸ=0.76). The N669Y (16.1%), D734Y (28.6%) and D734H (1.8%) isolates were found to have mutant Pfatpase6, however, these mutations were not associated with diminished DHA sensitivity (k=0.01). These high levels of antimalarial drug resistance in Abobo (Côte d’Ivoire) demand further studies of drug efficacy across the whole country.
10

The effects of bistramides on rodent malaria

67%
Gautret P., Le P. P., Biard J. F., Menard D., Verbist J. F., Marjolet M.
Acta Parasitologica
|
1998
|
tom 43
|
nr 1
Bistramide D and K were extracted from a New Caledonian marine colonial ascidian Lissoclinum bistratum and tested against Plasmodium berghei and P. vinckei petteri in mice. Bistramide D was able to reduce parasitaemia by almost 50% in P. berghei infected mice, but the ID₅₀ (>5 mg/kg) was very close to the LD₅₀ (8 mg/kg). In the same assay, bistramide K was less active than bistramide D. The mid-term trophozoite and the old trophozoite were shown to be the stages most sensitive to bistramide D in P. vinckei petteri infected mice. Therefore, bistramides are interesting experimental tools but do not present a major interest as potential antimalarial drugs.
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