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1

How chlorfenvinphos affects serum concentrations of transition metals, hydrogen peroxide and erythrocyte activity of superoxide dismutase

100%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2005
|
tom 14
|
nr 4
The aim of this paper was to examine the effects of chorfenvinphos on serum concentrations of transition metals, hydrogen peroxide and malondialdehyde (a lipid peroxidation index), and on the activity of superoxide dismutase in erythrocytes. Male Wistar rats were treated with vehicle or 0.02, 0.1 and 0.5 x LD50 of chlorfenvinphos and samples were collected at 1, 24 and 48 hr after treatment. The experiments were approved by the Local Ethics Committee. We demonstrated a decreased concentration of copper serum, which is accompanied by the increased activity of superoxide dismutase. The changes observed in the concentrations of copper can be explained by its displacement from serum to erythrocytes. We also observed increased levels of zinc serum (after intoxication with CVP at doses of 0.02 and 0.1 x LD50) and iron, as well as enhancement in hydrogen peroxide serum and malondialdehyde concentration. The changes in serum Zn concentration probably resulting from cellular membrane damage and the increase in serum iron concentration, is probably caused by its release from haemoglobin. The changes of serum Fe levels seems to have no effect on lipid peroxidation. We concluded that in acute intoxication with chlorfenvinphos — organophosphorus insecticide, the non-cholinesterase mechanismes are involved.
2

Studies on effect of pesticide chlorfenwinfos on mouse immune system

100%
Kowalczyk-Bronisz S., Gieldanowski J., Bubak B., Kotz J.
Archivum Immunologiae et Therapiae Experimentalis
|
1992
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tom 40
|
nr 5-6
3

Organophosphate insecticide chlorfenvinphos affects superoxide dismutase, catalase and malondialdehyde in rat liver

100%
Lukaszewicz-Hussain A.
Polish Journal of Environmental Studies
|
2001
|
tom 10
|
nr 4
The aim of this paper was to study the activity of liver superoxide dismutase and catalase and the concentration of liver malondialdehyde in rats intoxicated with chlorfenvinphos, an organophosphate widely used as an insecticide. The study was carried out on male Wistar rats weighing 180-230 g. The rats were divided into two groups: examined - receiving oil solution of chlorfenvinphos in doses of 0.5 LD50, and 0.1 LD50, and control group - receiving oil. The activity of superoxide dismutase (SOD), catalase (CAT) and concentration of malondialdehyde (MDA) were determined after 1, 24 and 48 hours of intoxication. We observed an increase in the liver activity of SOD in further period of intoxication with chlorfenvinphos in both doses and a decrease of liver SOD activity in the rats intoxicated with the higher dose. The CAT activity in liver of the treated rats increased at the 1st hour of experiment with a dose of 0.5 LD50 and at the Ist hour and the 24th hour after intoxication with a dose 0.1 LD50. Hepatic concentration of MDA showed a decrease at the 24th hour of intoxication with chlorfenvinphos and an increase at the 48th hour of intoxication with the higher dose and returned to control value for the rats intoxicated with the lower dose. SOD and CAT play a major role in the maintaince of the physiological level of reactive form of oxygen. When reactive oxygen species generation exceeds capability of redox degrading systems, MDA levels increase. The results obtained suggest that reactive oxygen species in liver injury might be caused by chlorfenvinphos.
4

Influence of age on picture of rat damage induced by chlorfenvinphos

100%
Kaminski M., Bienkowska M., Plewka A., Kaszuba M.
Acta Poloniae Toxicologica
|
1996
|
tom 04
|
nr 1
5

Wplyw podostrego zatrucia chlorfenwinfosem szczurow na aktywnosc aminotransferaz [AST i ALT]

84%
Jeleniewicz K., Maciejewska-Kozak H.
Bromatologia i Chemia Toksykologiczna
|
2001
|
tom 34
|
nr 2
181-183
6

Effect of combined treatment with a mixture of atropine, obidoxime and diazepam on reactivation of chlorfenvinphos inhibited brain and tissue cholinesterase activity in rats

84%
Raszewski G., Filip R.
Bulletin of the Veterinary Institute in Puławy
|
2006
|
tom 50
|
nr 3
7

A low dose of chlorfenvinphos affects hepatic enzymes in serum and antioxidant enzymes in erythrocytes and liver of rats

84%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2005
|
tom 14
|
nr 2
The aim of this study was to investigate the effect of chlorfenvinphos administered at a single dose of 0.02 LD50 on the activity of serum of liver damage indicatory enzymes, such as β-glucoronidase (BGR), acid phosphatase (AcP) and alanine and aspartate aminotransferases (ALT and AST), as well as on the activities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and liver. The animals were divided into two groups: the control group, which received oil, and the experimental groups, which received oil solution of chlorfenvinphos at a dose of 0.02 LD50. After 1, 24 and 48 hours of intoxication with chlorfenvinphos the blood samples were collected and livers were quickly removed. This study indicates that acute intoxication with chlorfenvinphos administered at a dose of 0.02 LD50 leads to liver function disturbances, which is a likely result of increased generation of reactive oxygen species.
8

The influence of pretreatment with N-acetylcysteine on serum cholinesterase activity and liver glutathione levels in rats intoxicated with chlorfenvinphos

84%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr 1
This study was intendent to examine if N-acetylcysteine (NAC) changes liver GSH levels and influences ChE serum activity in rats intoxicated with chlorfenvinphos. The studies were conducted on male Wistar rats of 200±20 g body weight. One group of rats was pretreated with 0.1% water solution of NAC. NAC was administered in drinking water 24h before intoxication. The control groups received oil intragastrically by stomach tube in the amount of 0.1ml/100g (I), immediately or after NAC pretreatment. The experimental groups received oil solution of chlorfenvinphos in a dose of 0.02 LD50 or 0.1 LD50 immediately or after pretreatment with NAC. One and 24 hours after intoxication with chlorfenvinphos (or after NAC pretreatment) the blood samples were collected and livers were quickly removed and placed in iced 0.9% NaCl containing 0.16 mg/ml heparin. ChE serum activity and GSH level were measured. The results of this study demonstrated the changes in serum ChE activity and liver glutathione levels in the rats after administration of chlorfenvinphos at single doses. The results reported here indicate that NAC influences a decreased level of GSH in the liver of chlorfenvinphos-intoxicated rats and does not prevent ChE inhibition.
9
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Content available

Impaired respiratory muscle function in chemical plant workers producing chlorfenvinphos

84%
Konieczny B., Kossmann S., Makuch M.
Annals of Agricultural and Environmental Medicine
|
1999
|
tom 06
|
nr 1
10

Obidoxime content in the brain tissue of rats intoxicated with organophosphate insecticide chlorfenvinphos after administration of Toxogonin

84%
Raszewski G., Burda S.
Acta Toxicologica
|
2006
|
tom 14
|
nr 1-2
11

Effect of chlorfenvinphos on the liver and plasma arginase activity in rats

84%
Maciejewska-Kozak H., Szczepaniak S.
Acta Poloniae Toxicologica
|
1996
|
tom 04
|
nr 2
12

Chlorfenvinphos, an organophosphate insecticide, affects liver mitochondria antioxidative enzymes, glutathione and hydrogen peroxide concentration

84%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr 4
Chlorfenvinphos is an organophosphate insecticide widely used alone or in combination in Poland. In the present study, the influence of chlorfenvinphos on the activity of mitochondrial antioxidative system as well as hydrogen peroxide concentration was examinated. The experiments were conducted on male Wistar rats of 180±20g body weight. The animals were divided into two groups: the control group, which received oil intragastrically by stomach tube and the experimental groups, which received oil solution of chlorfenvinphos in doses of 0.02 LD50, 0.1 LD50 or 0.5 LD50. After 1, 24, 48 hours the livers were quickly removed. Liver mitochondria were isolated as described elsewhere. Glutathione peroxidase, superoxide dismutase, isocitrate dehydrogenase activity as well as reduced glutathione and hydrogen peroxide concentrations were determined in liver mitochondria using BIOXYTECH Assay kits produced by OXIS International, Inc., Portland, USA. The results of this work indicate that chlorfenvinphos induces oxidative stress to rat liver mitochondria. In acute chlorfenvinphos intoxication, we demonstrated that the key role in the oxidative mitochondrial damage play MnSOD and GSH pool, as well as accumulation of hydrogen peroxide.
13

Liver catalase, glutathione peroxidase and reductase activity, reduced glutathione and hydrogen peroxide levels in acute intoxication with chlorfenvinphos, an organophosphate insecticide

84%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr 3
The aim of this study was to determine the effect of acute intoxication with chlorfenvinphos on the liver reduced glutathione (GSH) level and the activities of two enzymes involved in glutathione metabolism, as well as the activity of catalase (CAT), glucose-6-phosphate dehydrogenase (G6PDH) and the level of liver hydrogen peroxide. The concentration of malondialdehyde (MDA) was determined as lipid peroxidation index. Rats were divided into two groups: the control group, which received oil intragastrically by stomach tube, and the experimental groups, which received oil solution of chlorfenvinphos (CVP) in doses of 0.02 LD50, 0.1 LD50 or 0.5 LD50. After 1, 24, 48 hours of intoxication with chlorfenvinphos, the livers were quickly removed and placed in iced 0.9% NaCl containing 0.16 mg/ml heparin. The liver glutathione peroxidase (GPx) and reductase (GR) activities as well as GSH and hydrogen peroxide levels were determined using Bioxytech Assay kits. CAT activity was determined by Aebi method, G6PDH activity was measured using Sigma Assay kit. MDA level was determined by Buege and Aust method. The changes of examined parameters of antioxidative system as well as lipid peroxidation index were found. The correlation between MDA concentration and the elements of enzymatic and non-enzymatic antioxidative system was determined. A statistically significant correlation was found only between MDA level and G6PDH activity. In conclusion, it is suggested that G6PDH play a key role in the defence against oxidative stress induced by intoxication with chlorfenvinphos.
14

Ocena aktywnosci gamma-glutamylotransferazy i stezenia glutationu zredukowanego w watrobie szczura w ostrym zatruciu chlorfenwinfosem

67%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Roczniki Państwowego Zakładu Higieny
|
2002
|
tom 53
|
nr 2
119-124
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Methoxychlor, chlorfenvinphos, lindane, alfa-HCH and synthetic pyrethroids in soils of potato fields and surface waters in the South-Eastern Poland

67%
Sadlo S.
Prace Naukowe Instytutu Ochrony Roślin
|
1993
|
tom 35
|
nr 1-2
16

Organophosphate insecticide chlorfenvinphos affects enzymatic and nonenzymatic antioxidants in erythrocytes and serum of rats

67%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2003
|
tom 12
|
nr 4
Chlorfenvinphos, 2-chloro-1-(2,4-dichlorofenyl)vinyl diethyl phosphate, is an organophos-phate insecticide widely used in Poland singly or in mixture. The present study was undertaken to determine chlorfenvinphos-induced lipid peroxidation and to show whether acute intoxication with chlorfenvinphos alters the antioxidant system in the erythrocytes and serum. The study was conducted on male Wistar rats divided into two groups. The animals of control group were given olive oil intragastrically by a stomach tube, the animals of experimental group received oil solution of chlorfenvinphos (CVP) at a dose of 0.02, 0.1 or 0.5LD50. The blood was collected via heart puncture at the 1st, 24th and 48th hour after treatment. We determined the erythrocytes concentration of glutathione, the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase as well as the serum concentration of ascorbic acid, á-to-copherol and malondialdehyde. We observed the stimulation of enzymatic and nonenzymatic antioxi-dant system and lipid peroxidation in the erythrocytes and serum of chlorfenvinphos intoxicated rats.
17

Influence of 30-day subacute intoxication with chlorfenvinphos and lead on some biochemical parameters in rats

67%
Maciejewska-Kozak H., Dudka J., Dawidek-Pietryka K., Jeleniewicz K.
Acta Poloniae Toxicologica
|
2001
|
tom 09
|
nr 2
18

Effects of joint action of some carbamate insecticides in rats

67%
Wysocka-Paruszewska B., Osicka-Koprowska A., Brzezinski J.
Acta Poloniae Toxicologica
|
1995
|
tom 03
|
nr 2
19

Effect of subacute intoxication with chlorfenvinphos on some biochemical indicatory parameters of liver and kidney injury

67%
Maciejewska-Kozak H., Jeleniewicz K., Szczepaniak S.
Acta Poloniae Toxicologica
|
2001
|
tom 09
|
nr 1
20

Wplyw zatrucia ostrego chlorfenwinfosem na aktywnosc enzymow antyoksydacyjnych oraz stezenie dialdehydu malonowego u szczurow

59%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Roczniki Państwowego Zakładu Higieny
|
1999
|
tom 50
|
nr 3
307-311
Zbadano wpływ podania chlorfenwinfosu w jednorazowej dużej dawce na aktywność enzymów antyoksydacyjnych i stężenie diadehydu malonowego we krwi szczurów.
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