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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Mechanism of inhibition of smooth muscle of guinea-pig taenia coli by chloramphenicol

100%
Pramanik P., Datta S. C., Mitra C.
Journal of Physiology and Pharmacology
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1994
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tom 45
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nr 1
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Determination of chloramphenicol in milk powder using liquid-liquid cartridge extraction (Chem Elut) and liquid chromatography-tandem mass spectrometry

86%
Zawadzka I., Rodziewicz L.
Roczniki Państwowego Zakładu Higieny
|
2014
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tom 65
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nr 3
Background. The European Union prohibits the use of chloramphenicol (CAP) as a veterinary drug in food-producing animals. Nevertheless, CAP have been detected in milk products (liquid milk and milk powder). Therefore, it is necessary to develop sensitive methods for determining CAP residues in milk powder. Objective. The aim of this study was to develop and validate a confirmatory method for determination of CAP in milk powder. Material and methods. Chloramphenicol was determined in milk powder using LC-ESI-MS/MS in negative mode. After fat removing milk powder sample was extracted/cleaned-up with a Chem Elut extraction cartridge. Separation was achieved on a Phenomenex Luna C-18 column with acetonitrile-water as a mobile phase. The mass spectrometer was operated in multiple reaction monitoring mode (MRM). Four transitions were monitored m/z 321→152, 321→194, 321→257 (CAP) and 326→157 (IS CAP-d5). Results. Linearity, accuracy, precision, decision limit (CCa), detection capability (CCb) and ruggedness were determined for m/z 321→152. The mean relative recoveries (inter standard-corrected) of CAP from whole milk powder spiked at levels 0.1, 0.2, 0.3 and 0.6 mg/kg were in the range 95 - 103%. Relative standard deviation (RSD%) of recoveries at all spiked levels were less than 14%. RSDs within-laboratory reproducibility calculated at fortification of 0.3 mg/kg was less than 16%. CCa and CCb were below 0.1 mg/kg. Conclusions. The developed LC-MS/MS method allows the determination of CAP in milk powder. The method was validated according to the Commission Decision No. 2002/657/EC requirements. This method can be applied to determination CAP in whole and skim milk powder.
3

Determination of chloramphenicol residues in milk by gas and liquid chromatography mass spectrometry methods

86%
Sniegocki T., Posyniak A., Zmudzki J.
Bulletin of the Veterinary Institute in Puławy
|
2007
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tom 51
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nr 1
Analytical methods based on gas chromatography- mass spectrometry (GC-MS/MS) and liquid chromatography- mass spectrometry (LC-MS/MS) were developed for the determination of chloramphenicol (CAP) in milk. GC-MS/MS was performed in negative chemical ionization (NCI) mode by monitoring the transitions - m/z 466→304, 466→322, and the results were compared with LC-MS/MS, in electrospray mode by monitoring the transitions of all the selected ions m/z 321→152, 321→257. The decision limit (CCα) for CAP determination by LC-MS/MS was established at a level of 0.11 µg/kg, while the corresponding value for GC-MS/MS was 0.083 µg/kg. Detection capability (CCß) for CAP by LC- MS/MS was 0.15µg/kg and for GC-MS/MS was 0.14 µg/kg. As it was found, both methods are useful for CAP determination in milk.
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The effect of chloramphenicol on mucosal transference of glucose in mice ; the role of intestinal alkaline phosphatase in this process

86%
Pramanik P., Datta S. C., Mitra C.
Journal of Physiology and Pharmacology
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1993
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tom 44
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nr 4
5

The effect of the chemical structure of polyene macrolides on the permeability of the Chlorella vulgaris plasma membrane

72%
Malewicz B.
Oceanologia
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1976
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tom 06
6

Genetic translocation of resistance determinants in Staphylococcus aureus

72%
Mlynarczyk A., Mlynarczyk G., Grzesik A., Sawicka-Grzelak A., Lipnicki D., Dworczynski A., Osowiecki H.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1987
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tom 35
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nr 4-6
7

Determination of chloramphenicol in animal urine by liquid chromatography-tandem mass spectrometry

72%
Rodziewicz L., Zawadzka I.
Bulletin of the Veterinary Institute in Puławy
|
2008
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tom 52
|
nr 3
The method was developed for the determination of chloramphenicol (CAP) in animal urine using LC-ESI-MS- MS. The sample was diluted with water, loaded onto a Chem Elut cartridge, and eluted with ethyl acetate. LC separation was achieved by using a Phenomenex Luna C-18 column. The mass spectrometer was operated in multiple reaction monitoring mode (MRM) with negative electrospray interface (ESI-). The four transitions were monitored m/z 321—>257, 321—> 194, 321—> 152, 326—> 157(IS) and for quantification, the transition m/z 326—>152 was chosen. The method validation was done according to the criteria laid down in Commission Decision No. 2002/657/EC. The validation includes the determination of specification, linearity, repeatability, within-laboratory reproducibility, accuracy, trueness, decision limit (CCα), and detection capability (CCβ). Urine_samples were fortified at CAP levels 0.30, 0.45, and 0.60 µg/kg with CAP-d5 as internal standard. At these levels, repeatability (RSD %) was lower than 9%, accuracy (RE, %) ranged from -8.7% to 0.4% and mean trueness (recovers) was between 91% and 100%. RSD within-laboratory reproducibility was lower than 10%. The limit of decision (CCα) and detection capability (CCβ) was 0.08 and 0.10 µg/kg.
8

Validation of the gas chromatography-mass spectrometry method for the determination of chloramphenicol residues in milk

72%
Sniegocki T., Posyniak A., Zmudzki J.
Bulletin of the Veterinary Institute in Puławy
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2006
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tom 50
|
nr 3
9

The alternative and the cytochrome pathway activity in amoeba mitochondria from chloramphenicol-, antimycin A-treated and iron-deficient cultures

72%
Hryniewiecka L., Jarmuszkiewicz W., Szalata M., Michejda J.
Biological Bulletin of Poznań
|
1997
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tom 34
10

Oznaczanie pozostalosci chloramfenikolu w moczu bydla z zastosowaniem polimerow z odwzorowaniem czasteczkowym metoda LC-MS-MS

58%
Rodziewicz L.
Bromatologia i Chemia Toksykologiczna
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2010
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tom 43
|
nr 2
222-227
11

Oznaczanie pozostalosci chloramfenikolu w tkankach zwierzat metoda LC-MS-MS

58%
Rodziewicz L., Zawadzka I.
Roczniki Państwowego Zakładu Higieny
|
2006
|
tom 57
|
nr 1
31-38
W pracy przedstawiono metodę potwierdzającą oznaczania chloramfenikolu w tkance mięśniowej zwierząt przy zastosowaniu techniki LC-MS/MS spełniającej zalecenia Decyzji Komisji nr 2003/181/WE i nr 2002/657/WE.
12
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Zastosowanie polimerów z odwzorowaniem cząsteczkowym do oznaczania pozostałości chloramfenikolu w mleku w proszku metodą LC-MS/MS

58%
Rodziewicz L., Zawadzka I.
Roczniki Państwowego Zakładu Higieny
|
2010
|
tom 61
|
nr 3
Przedstawiono metodę oznaczania chloramfenikolu w mleku proszku. Próbki były oczyszczane przy zastosowaniu polimerów z odwzorowaniem cząsteczkowym (МІР). Analizę przeprowadzono w układzie LC-ESI-MS/MS z zastosowaniem kolumny Luna C 18 Phenomenex. Jako standard wewnętrzny zastosowano CAP-d5. Metodę zwalidowano zgodnie z kryteriami decyzji Komisji nr 2002/657/WE. Średni odzysk próbek wzmocnionych na poziomie 0,3 µg/kg mieścił się w zakresie 104-111%. Limit decyzyjny (CCα) i zdolność wykrywania (CCß) wynosiły odpowiednio 0,06 µg/kg i 0,09 µg/kg.
13

Influence of enrofloxacin and chloramphenicol on the level of IgY in serum and egg yolk after immunostimulation of hens with Salmonella enteritidis antigens

58%
Tokarzewski S.
Polish Journal of Veterinary Sciences
|
2002
|
tom 05
|
nr 3
14

Zastosowanie chromatografii cieczowej - spektrometrii mas do oznaczania pozostalosci chloramfenikolu w produktach pochodzenia zwierzecego

58%
Rodziewicz L., Zawadzka I.
Bromatologia i Chemia Toksykologiczna
|
2006
|
tom 39
|
nr 2
197-203
15

In vitro study on the effect of chloramphenicol and florfenicol on cellular and humoral immunity of carp [Cyprinus carpio] and rabbit [Oryctolagus cuniculus]

58%
Sieroslawska A., Studnicka M., Siwicki A. K., Bownik A., Rymuszka A.
Acta Poloniae Toxicologica
|
2000
|
tom 08
|
nr 1
16

Chloramphenicol, an inhibitor of mitochondrial protein synthesis, inhibits myoblast fusion and myotube differentiation

58%
Korohoda W., Pietrzkowski Z., Reiss K.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 1
17

Antibiotic resistance of Campylobacter jejuni with reference to plasmid profiles of clinical and chicken isolates

58%
Lekowska-Kochaniak A., Rozynek E., Popowski J.
Acta Microbiologica Polonica
|
1996
|
tom 45
|
nr 3-4
18

Characteristics of Staphylococcus aureus isolates from atopic dermatitis with reference to proteolytic activity

51%
Baran-Raunstrup K., Miedzobrodzki J., Ternowitz T.
Acta Microbiologica Polonica
|
1998
|
tom 47
|
nr 2
19

Rhythm of sporulation within the section Penicillium clavigerum. III. Induction of growth and zonation rhythms in Penicillium isariiforme Stolk and Meyer 247.56

51%
Piskorz-Binczycka B.
Acta Biologica Cracoviensia. Series Botanica
|
1994
|
tom 36
In Penicilium isariiforme there occur two endogenous rhythms: the growth-“wave” rhythm and sporulation rhythm in the form of coremia-bearing zonations. The growth rhythm of wave type occurring in P. isariiforme in light and in darkness is an endogenous spontaneous rhythm, whereas the sporulation rhythm manifested by the formation of spore-bearing coremia zonations represents an analogue induced rhythm. For this rhythm to occur a light impulse is necessary. The growth-wave rhythm has a long period 120 h, the sporulation rhythm has a 30 h period. Asparagine seems to regulate the sporulation rhythm; but it does not exert any greater influence on the wave rhythm in cultures grown in light nor in darkness. An addition of asparagine shortened the period of first zonation by a few hours, and the successive sporulation periods followed within very short time. Inhibitors such as: avidin. chloramphenicol, cycloheximide and puromycine controlled the length of the period of the sporulation rhythm.
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