Ograniczanie wyników

Czasopisma help
Autorzy help
Lata help
Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 79

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 4 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  chloniaki
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 4 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
Malignant lymphomas (ML), actually lymphomas, are common tumors in dogs, outnumbered only by mammary and cutaneous tumors. The existing morphological classifications of canine ML have been based successively on different human classifications, including Rappaport, the Working Formulation and the Kiel classification. The behavior of canine malignant lymphomas is difficult to predict on the basis of histomorphology alone, and thus other advanced techniques are needed in the establishment of prognostic factors. Evaluation of tumors phenotype (B cell and T cells), proliferation rate (mitotic index, Ki67 expression, AgNORs number) in histologic sections is possible and often enables a precise diagnosis. Fine-needle aspiration cytology remains the first line of investigation (screening test) used in all cases of mono- or polylymphadenopathy. It helps to obtain initial diagnosis (lymphoma, metastases, hyperplasia), in staging the disease, in the detection of the recurrence and progression of the neoplastic process. Lymphomas have successfully been classified by FNA cytology, in human medicine the success rate of this procedure ranges from 80% to 90% in the diagnosis of malignant lymphoma and 67.5% to 86% in its subtyping. Cytology is a safer, cheaper, and more rapid procedure than histology, and the owner often disagrees to the surgical procedure essential to obtaining tissue samples. Immonophenotyping, can be successfully established in aspiration biopsy samples of enlarged lymph nodes in dogs with lymphoma. Moreover, the evaluation of the proliferation rate of neoplastic cells by immunocytochemy or other cytopathologic stains can also be made.
Lymphomas, which originate from various forms of lymphocytes, are the most common hematological malignancies in dogs. Their etiology is complicated because of the lack of clearly identified pathological factors. In the current WHO classification there are three main groups of tumors: B-cell lymphomas, lymphomas with T and NK cells and Hodgkin’s disease. Lymphomas originating from B cell lines represent about 80 percent of non-Hodgkin lymphomas. This paper presents our experiences in the diagnostics of lymphadenopathy. A 7-year-old male dog was brought to hospital because of a generalized enlargement of lymph nodes. Diagnostic procedures performed on the dog included a clinical examination, laboratory examinations of blood, ECG, X-ray and ultrasound examinations, two aspiration biopsies (FNAB) as well as a histopathological examination of a lymph node. Lymphoma therapy was administered in accordance with the COP chemotherapy protocol. Results of the clinical examination and laboratory tests confirmed the diagnosis of B-cell malignant lymphoma - lymphoblastic type. Lymphoma diagnostics are based on cytological and histopathological examinations and the cell proliferation ratio. The phenotype of the lymphoma is important for prognosis. The use of specific antibodies for the identification of CD surface antigens, including certain cell lines, is helpful in the diagnosis. The longest period of survival and control of the disease can be obtained by treatment with doxorubicin combined with simultaneous radiotherapy. In the case of recurrence, dacarbazine (DTIC) therapy is effective.
Telomerase is a ribonucleoprotein enzyme responsible for the protection of telomeres - structures which play a key role in stabilizing chromosomes. Its presence assures the possibility of tissue regeneration and unlimited cell division. On the physiological level telomerase activity is present in germline cells, embryonic tissues and some hematopoetic stem cells and, on a pathological level, in neoplastic cells. Its expression causes uncontrolled cell proliferation and may be a characteristic marker of neoplastic transformation and tumor progression. The aim of the study was to present the presence of telomerase in neoplastic lymphocytes in cases of lymphoma malignum in dogs. Cytoimmunological procedure with Telomerase (catalytic unit) NCL-L-hTERT (Novocastra Ltd product) was used to locate telomerase in malignantly transformed lymphocytes and in normal lymphocytes. The study indicated that telomerase is not present in normal lymphocytes. Higher levels of telomerase were observed in cenroblastic and immunoblastic lymphoma cells, compared with lower amounts of the enzyme in lymphoma malignum lymphocyticum B cells. A distinct presence of the enzyme was also noted in lymphoma cells of skin T-receptors. The level of this ribonucleoprotein may serve as a malignancy marker of transformed lymphocytes.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 4 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.